Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma

Patrícia Dias de Araújo, Ana Paula Duarte de Souza, Cristina Beatriz Bonorino


Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.

Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.

Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.

Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9.


Interleukin-9, T helper cells, and TGF-β

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