Th9 cells and interleukin-9 in the pathogenesis of asthma / Células Th9 e Interlecuina-9 na patogenia da asma

Patrícia Dias de Araújo, Ana Paula Duarte de Souza, Cristina Beatriz Bonorino

Abstract


Objective: The aim of this study was to review the key information about the recent subtype of Th9 cells and interleukin-9 in the pathology of asthma.

Data source: It was surveyed in the databases Medline/Pubmed and OVID, original papers published between 1997 and 2012, in English and Spanish, using the selected descriptors.

Data synthesis: Asthma is a problem of public health, and its pathophysiology includes subtype of cells of the T helper family and their respective cytokines. The cytokine IL9 is produced by CD4 T cells by activation of transcription factors IRF4 and PU.1. Th9 mainly produce IL9, but Th2 can also secrete this cytokine. IL9 is involved of pathology of asthma by increasing of airway hyperresponsiveness and eotaxin release by lung epithelial cells. Moreover, inhibition of IL9 in asthma has been studied and reported as a preventive and inhibitory airway remodeling in mice.

Conclusion: Nowadays, the discovery of new treatments for allergic asthma is essential. Studying this new subtype of helper T cells and understanding its involvement in the development of asthma may provide a possibility of new treatments, such as inhibiting the production of IL9.


Keywords


Interleukin-9, T helper cells, and TGF-β

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References


Magnus P, Jaakkola JJ. Secular trend in the occurrence of asthma among children and young adults: critical appraisal of repeated cross sectional surveys. BMJ. 1997;314(7097):1795-9.

Menz G, Ying S, Durham SR, Corrigan CJ, Robinson DS, Hamid Q, et al. Molecular concepts of IgE-initiated inflammation in atopic and nonatopic asthma. Allergy. 1998;53(45 Suppl):15-21.

Machura E, Mazur B, Rusek-Zychma M, Barć-Czarnecka M. Cytokine production by peripheral blood CD4+ and CD8+ T cells in atopic childhood asthma. Clin Dev Immunol. 2010;2010:606139.

Vock C, Hauber HP, Wegmann M. The other T helper cells in asthma pathogenesis. J Allergy (Cairo). 2010;2010:519298.

Hirahara K, Poholek A, Vahedi G, Laurence A, Kanno Y, Milner JD, et al. Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J Allergy Clin Immunol. 2013;131(5):1276-87.

Malmhäll C, Bossios A, Rådinger M, Sjöstrand M, Lu Y, Lundbäck B, et al. Immunophenotyping of circulating T helper cells argues for multiple functions and plasticity of T cells in vivo in humans--possible role in asthma. PLoS One. 2012;7(6):e40012.

Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol. 2008;9(12):1341-6.

Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008;9(12):1347-55.

Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, et al. Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site. J Immunol. 2010;185(11):6795-801.

Horka H, Staudt V, Klein M, Taube C, Reuter S, Dehzad N, et al. The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. J Immunol. 2012;188(6):2669-76.

Loza MJ, Foster S, Bleecker ER, Peters SP, Penn RB. Asthma and gender impact accumulation of T cell subtypes. Respir Res. 2010;11:103.

Barnes PJ. Pathophysiology of allergic inflammation. Immunol Rev. 2011;242(1):31-50.

Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716-25.

McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol. 2005;174(9):5774-80.

Reader JR, Hyde DM, Schelegle ES, Aldrich MC, Stoddard AM, McLane MP, et al. Interleukin-9 induces mucous cell metaplasia independent of inflammation. Am J Respir Cell Mol Biol. 2003;28(6):664-72.

Böttcher MF, Bjurström J, Mai XM, Nilsson L, Jenmalm MC. Allergen-induced cytokine secretion in atopic and non-atopic asthmatic children. Pediatr Allergy Immunol. 2003;14(5):345-50.

Chiba Y, Kusakabe T, Kimura S. Decreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9. Am J Physiol Lung Cell Mol Physiol. 2004;287(6):L1193-8.

Baraldo S, Faffe DS, Moore PE, Whitehead T, McKenna M, Silverman ES, et al. Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK. Am J Physiol Lung Cell Mol Physiol. 2003;284(6):L1093-102.

Bhathena PR, Comhair SA, Holroyd KJ, Erzurum SC. Interleukin-9 receptor expression in asthmatic airways In vivo. Lung. 2000;178(3):149-60.

Hültner L, Druez C, Moeller J, Uyttenhove C, Schmitt E, Rüde E, et al. Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGFIII (interleukin 9). Eur J Immunol. 1990;20(6):1413-6.

Namkung JH, Lee JE, Kim E, Park GT, Yang HS, Jang HY, et al. An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population. J Dermatol Sci. 2011;62(1):16-21.

Gounni AS, Gregory B, Nutku E, Aris F, Latifa K, Minshall E, et al. Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Blood. 2000;96(6):2163-71.

Erpenbeck VJ, Hohlfeld JM, Volkmann B, Hagenberg A, Geldmacher H, Braun A, et al. Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes. J Allergy Clin Immunol. 2003;111(6):1319-27.

Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, et al. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 2009;106(31):12885-90.

Kaplan MH. Th9 cells: differentiation and disease. Immunol Rev. 2013;252(1):104-15.

Kajiyama Y, Umezu-Goto M, Kobayashi N, Takahashi K, Fukuchi Y, Mori A. IL-2-induced IL-9 production by allergen-specific human helper T-cell clones. Int Arch Allergy Immunol. 2007;143 Suppl 1:71-5.

Knoops L, Louahed J, Van Snick J, Renauld JC. IL-9 promotes but is not necessary for systemic anaphylaxis. J Immunol. 2005;175(1):335-41.

Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, et al. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010;185(1):46-54.

Goswami R, Jabeen R, Yagi R, Pham D, Zhu J, Goenka S, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188(3):968-75.

Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity. 2010;33(2):192-202.

Honma K, Kimura D, Tominaga N, Miyakoda M, Matsuyama T, Yui K. Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells. Proc Natl Acad Sci U S A. 2008;105(41):15890-5.

Xiao X, Balasubramanian S, Liu W, Chu X, Wang H, Taparowsky EJ, et al. OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol. 2012;13(10):981-90.

Cortelazzi C, Campanini N, Ricci R, De Panfilis G. Inflammed skin harbours Th9 cells. Acta Derm Venereol. 2012.

Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, et al. Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity. 2010;33(2):192-202.

Ciprandi G, De Amici M, Giunta V, Marseglia A, Marseglia G. Serum Interleukin-9 Levels Are Associated With Clinical Severity in Children With Atopic Dermatitis. Pediatr Dermatol. 2012.

Fawaz LM, Sharif-Askari E, Hajoui O, Soussi-Gounni A, Hamid Q, Mazer BD. Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion. J Allergy Clin Immunol. 2007;120(5):1208-15.

Melén E, Gullstén H, Zucchelli M, Lindstedt A, Nyberg F, Wickman M, et al. Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation. J Med Genet. 2004;41(12):e123.

Devos S, Cormont F, Vrtala S, Hooghe-Peters E, Pirson F, Snick J. Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. Clin Exp Allergy. 2006;36(2):174-82.

Gounni AS, Hamid Q, Rahman SM, Hoeck J, Yang J, Shan L. IL-9-mediated induction of eotaxin1/CCL11 in human airway smooth muscle cells. J Immunol. 2004;173(4):2771-9.

Kearley J, Erjefalt JS, Andersson C, Benjamin E, Jones CP, Robichaud A, et al. IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med. 2011;183(7):865-75.

Holgate ST. Pathogenesis of asthma. Clin Exp Allergy. 2008;38(6):872-97.

Okude A, Tagaya E, Kondo M, Nonaka M, Tamaoki J. A Case of Severe Asthma with Eosinophilic Otitis Media Successfully Treated with Anti-IgE Monoclonal Antibody Omalizumab. Case Rep Pulmonol. 2012;2012:340525.

Büttner C, Lun A, Splettstoesser T, Kunkel G, Renz H. Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions. Eur Respir J. 2003;21(5):799-803.




DOI: https://doi.org/10.34117/bjdv6n4-238

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