Nanopartículas sólidas lipídicas e sua aplicação na entrega de compostos ativos naturais / Solid lipidic nanoparticles and their application in the delivery of natural active compounds

Thiellen Wrobel Kultz de Lima, Dani Fernanda Renzi, Laís de Almeida Campos

Abstract


Nanopartículas Sólidas Lipídicas (NSL's) são conhecidas pelo papel importante na entrega de drogas e compostos através de diferentes vias como oral, ocular, tópica e sistêmica. Entre as vantagens na utilização deste sistema está o aumento da biodisponibilidade, liberação sustentada e lenta alvo direcionada. Como um potencial sistema de entrega as NSL’s são uma alternativa para entrega de compostos ativos naturais. Apesar do potencial terapêutico destes compostos, algumas limitações como a baixa solubilidade em meio aquoso, degradação no trato gastrointestinal e baixa permeabilidade de membrana e estabilidade que limitam seu potencial terapêutico. Nesse sentido, sistema de entrega destes compostos utilizando NSL’s tem sido desenvolvidos e apresentado resultados interessantes para aplicação clínica. No entanto, ainda é necessário avanço em estudos clínicos e padronização de metodologias neste campo de estudo. Nesta revisão, nós apresentamos uma visão geral da utilização das NSL’s e como ela tem sido explorada nos últimos anos para encapsular compostos ativos naturais.


Keywords


nanopartículas sólidas lipídicas, compostos naturais ativos, lipídeos.

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DOI: https://doi.org/10.34117/bjdv7n12-018

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