Complicações neurológicas associadas à infecção por COVID-19: uma revisão integrativa / Neurological complications associated with COVID-19 infection: an integrative review

Anny Caroline Ribeiro Devechi, Gabriel Pavinati, Caroline Sala, Vinícius Brito de Souza, Nayara Sâmela Oliveira Souto, Marcelle Paiano

Abstract


O Coronavírus (COVID-19) consiste em um vírus de RNA, da ordem Nidovirales e da família Coronaviridae. Apesar da gama de sintomas respiratórios, as manifestações neurológicas, como a cefaleia, anosmia, tontura, ageusia e comprometimento da consciência tem sido relatadas. Identificar as publicações relacionadas às complicações neurológicas decorrentes da infecção por COVID-19 em pacientes adultos. trata-se de uma revisão integrativa da literatura com estudos publicados entre janeiro de 2020 a julho de 2021, filtrados nas seguintes plataformas: PubMed, Scopus, WOS e BVS. Foram identificadas 957 publicações, das quais 31 foram extraídas para a análise. As principais complicações neurológicas evidenciadas foram os acidentes vasculares cerebrais, hemorragias intracranianas, distúrbios desmielinizantes, encefalites, encefalopatias, vasculopatias e delirium. Outros casos menos comuns, mas de importância clínica relevante, incluíram os distúrbios de visão, distúrbios na fala e convulsões. Postula-se a necessidade de considerar a infecção por SARS-CoV-2 como um diagnóstico diferencial em pacientes com manifestações neurológicas.


Keywords


COVID-19, Sistema Nervoso, Manifestações Neurológicas.

References


ÁGUILA-GORDO, D. et al. Acute myelitis and SARS-CoV-2 infection. A new etiology of myelitis? Journal of Clinical Neuroscience, v. 80, p. 280-281, 2020. DOI: 10.1016/j.jocn.2020.07.074

AMANATE, M. et al. Neurological manifestations as the predictors of severity and mortality in hospitalized individuals with COVID-19: a multicenter prospective clinical study. BMC Neurol., v. 21, n. 116, p. 1-12, 2021. DOI: 10.1186/s12883-021-02152-5.

BEACH, S. R. et al. Delirium in COVID-19: A case series and exploration of potential mechanisms for central nervous system involvement. Gen Hosp Psychiatry., v. 65, p. 47-53, 2020. DOI: 10.1016/j.genhosppsych.2020.05.008

BOZZALI, M. et al. Focal seizures with impaired awareness as long-term neurological complication of COVID-19: a case report. Neurol Sci., v. 42, p. 2619-2623, 2021. DOI: 10.1007/s10072-021-05233-y

BRASIL, MINISTÉRIO DA SAÚDE. Protocolo de atendimento do novo Coronavírus. Biblioteca Virtual de Saúde, Brasília – DF, 1° ed, 2020. Disponível em: https://portalarquivos2.saude.gov.br/images/pdf/2020/fevereiro/05/Protocolo-de-manejo-clinico-para-o-novo-coronavirus-2019-ncov.pdf. Acesso em 22 de julho de 2021.

CHIA, K. X. et al. Possible affective cognitive cerebellar syndrome in a young patient with COVID-19 CNS vasculopathy and stroke. BMJ journals, v. 13, n. 10, p. 1-4, 2020. DOI: 10.1136/bcr-2020-237926

COTELLI, M. S. et al. Effortful speech with distortion of prosody following SARS-CoV-2 infection. Neurological Sciences, v. 41, p. 3767-3768, 2020. DOI: 10.1007/s10072-020-04603-2

CROSTA, F. et al. Neurological features of COVID-19 infection: a case series of geriatric patients. Journal of Gerontology and Geriatrics, v. 68, n. 4, p. 235-239, 2020. DOI: 10.36150/2499-6564-282

DALAHMAH, O. A. et al. Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage. Acta Neuropathologica Communications, v. 8, n. 147, p. 2-7, 2020. DOI: 10.1186/s40478-020-01024-2

DELORME, C. et al. Covid‐19‐related encephalopathy: a case series with brain FDG‐PET/CT findings. European Journal of Neurology, v. 27, p. 2651-2657, 2020. DOI:10.1111/ene.14478

DONO, F. et al. New-onset refractory status epilepticus (NORSE) in post SARS-CoV-2 autoimmune encephalitis: a case report. Neurol Sci. v. 3, p. 1-4, 2020. DOI: 10.1007/s10072-020-04846-z

FOTUHI, M. et al. Neurobiology of COVID-19. Journal of Alzheimer’s Disease. n. 76, v. 1, p. 3-19, 2020. DOI: 10.3233/JAD-200581.

GHOSH, R. et al. SARS-CoV-2-Associated Acute Hemorrhagic, Necrotizing Encephalitis (AHNE) Presenting with Cognitive Impairment in a 44-Year-Old Woman without Comorbidities: A Case Report. American Journal of Case Reports, v. 21, p. 1-5, 2020. DOI: 10.12659/AJCR.925641

GOLDBERG, M. F. et al. Cerebrovascular Disease in COVID-19. American Journal of Neuroradiology, v. 41, n. 7, p. 1170-1172, 2020. DOI: 10.3174/ajnr.A6588

GRAHAM, E. L. et al. Persistent neurologic symptoms and cognitive dysfunction in non-hospitalized Covid-19 “long haulers”. Annals of Clinical and Translational Neurology, v. 8, n. 5, p. 1073-1085, 2021. DOI: 10.1002/acn3.51350

HANAFI, R. et al. COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern. American Journal of Neuroradiology, v. 41, p. 1384-1387, 2020. DOI: 10.3174/ajnr.A6651

HUANG, Y. H. et al. SARS-CoV-2 Detected in Cerebrospinal Fluid by PCR in a Case of COVID-19 Encephalitis. Brain Behav Immun. v. 87, n. 149, 2020. DOI: 10.1016/j.bbi.2020.05.012

KARADAS, O. et al. A prospective clinical study of detailed neurological manifestations in patients with COVID-19. Neurological Sciences, v. 41, p. 1991-1995, 2020. DOI: 10.1007/s10072-020-04547-7

KINCAID, K. J. et al. Post-COVID seizure: A new feature of “long-COVID”. ENeurologicalSci, v. 23, p. 1-4, 2021. DOI: 10.1016/j.ensci.2021.100340

LASCANO, A. M. et al. SARS-CoV-2 and Guillain–Barré syndrome: AIDP variant with a favourable outcome. European Journal of Neurology, v. 27, p. 1751-1753, 2020. DOI: 10.111/ene.14368

LERSY, F. et al. Cerebral vasculitis of medium-sized vessels as a possible mechanism of brain damage in COVID-19 patients. Journal of Neuroradiology, v. 48, p. 141-146, 2021. DOI: 10.1016/j.neurad.2020.11.004

LIVELY, S. et al. Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10). Front Cell Neurosci., v. 12, n. 215, p. 1-19, 2018. DOI: 10.3389/fncel.2018.00215

LODIGIANI, C. et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. v. 191, p. 9-14, 2021. DOI: 10.1016/j.thromres.2020.04.024

MAO, L. et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurology, v. 77, n. 6, p. 683-690, 2020. DOI: 10.1001/jamaneurol.2020.1127

MELEGARI, G. et al. Mild to Severe Neurological Manifestations of COVID-19: Cases Reports. Int J Environ Res Public Health, v. 18, n. 7, p. 1-10, 2021. DOI: 10.3390 / ijerph18073673.

MENDES, K. D. S. et al. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto Contexto Enfermagem. Florianópolis, v. 17, n. 4, p. 758-64, 2008. DOI: 10.1590/S0104-07072008000400018

MENDES, P. B. et al. Origem e desenvolvimento da mielina no sistema nervoso central - um estudo de revisão. Revista Saúde e Pesquisa, v. 4, n. 1, p. 93-99, 2011. Disponível em: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1654/1208. Acesso em: 3 de agosto de 2021.

MEPPIEL, E. et al. Neurologic manifestations associated with COVID-19: a multicentre registry. Clin Microbiol Infect. v. 27, n. 3, p. 458-466, 2021. DOI: 10.1016/j.cmi.2020.11.005

MOHER, D. et al. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Medicine. v. 6, n.7, p. 1-6, 2009. DOI: 10.1371/journal.pmed.1000097

MURCHISON, A. P. et al. Monocular visual loss as the presenting symptom of COVID-19 infection. Clinical Neurology and Neurosurgery, v. 201, p. 1-4, 2021. DOI: 10.1016/j.clineuro.2020.106440

NAPOLEÃO, R. M. N. COVID-19: Compreendendo a “tempestade de citocinas”. Research, Society and Development”, v. 10, n. 5, p. 1-12, 2021. DOI: 10.33448/rsd-v10i5.15150

NEEDHAM, E. J. et al. Neurological Implications of COVID-19 Infections. Neurocrit Care, v. 32, n. 3, p. 667-671, 2020. DOI: 10.1007/s12028-020-00978-4

PANIZ-MONDOLFI, A. et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol. v. 92, n. 7, p. 699-702, 2020. DOI: 10.1002/jmv.25915.

PAVINATI, G. et al. Perfil clínico dos pacientes acometidos pela Covid-19: revisão integrativa. Brazilian Journal of Development, v. 7, n. 7, p. 74945 -74964, 2021. DOI: 10.34117/bjdv7n7-598

PLACANTONASKI, D. G. et al. SARS-CoV-2 Is Not Detected in the Cerebrospinal Fluid of Encephalopathic COVID-19 Patients. Front Neurol. v. 11, p. 1-7, 2020. DOI: 10.3389/fneur.2020.587384

RADNIS, C. et al. Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia. Journal of the Neurological Sciences, v. 418, p.1-5, 2020. DOI: 10.1016/j.jns.2020.117119

ROBLES, L. A. Bilateral Large Vessel Occlusion Causing Massive Ischemic Stroke in a COVID-19 Patient. J Stroke Cerebrovasc Dis., v. 30, n. 3, p. 1-3, 2021. DOI: 10.1016/j.jstrokecerebrovasdis.2021.105609

RODRÍGUEZ, M. S. R. et al. Optic neuritis following SARS-CoV-2 infection. J Neurovirol. v. 23, p. 1-5, 2021. DOI: 10.1007/s13365-021-00959-z

ROMÁN, G. C. et al. Acute Transverse Myelitis (ATM): Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events with the ChAdOx1 nCoV-19 Vaccine (AZD1222). Front Immunol. v. 12, p. 1-11, 2021. DOI: 10.3389/fimmu.2021.653786

SANTOS, C. M. C. et al. A estratégia pico para a construção da pergunta de pesquisa e busca de evidências. Revista latino-americana de enfermagem. São Paulo, v. 15, n. 3, 2007. DOI: 10.1590/S0104-11692007000300023

SELVARAJ, V. et al. Acute Vision Loss in a Patient with COVID-19. Rhode Island Medical Journal (2013), v. 103, n. 6, p. 37-38, 2020. Disponível em: http://rimed.org/rimedicaljournal/2020/08/2020-08-37-extra-case-selvaraj.pdf. Acesso em 01 de agosto de 2021.

SHOSKES, A. et al. Cerebral Microhemorrhage and Purpuric Rash in COVID-19: The Case for a Secondary Microangiopathy. Journal of Stroke and Cerebrovascular Diseases, v. 29, n. 10, p. 1-3, 2020. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105111

SHI, Y. et al. An overview of COVID-19. J Zhejiang Univ Sci B. v, 21, n. 5, p. 343-360, 2020. DOI: 10.1631/jzus.B2000083

SILVA, F. S. C. A. et al. Neurological Dysfunction Associated with COVID-19. Revista Brasileira de Terapia Intensiva, v. 33, n. 2, p. 325-330, 2021. DOI: 10.5935/0103-507X.20210042

SOUSA, G. J. B. et al. Estimação e predição dos casos de COVID-19 nas metrópoles brasileiras. Revista Latino Americana de Enfermagem, v. 28, p. 1-8, 2020. DOI: 10.1590/1518-8345.4501.3345

STILLWELL, S. B. et al. Evidence-Based Practice, Step by Step: Asking the Clinical Question. American Journal of Nursing. v. 110, n. 3, p.2011. p.58-61, 2010.

TRITANY, E. F. et al. Fortalecer os Cuidados Paliativos durante a pandemia de Covid-19. Interface, v. 25, n. 1, p. 1-14, 2021. DOI: 10.1590/Interface.200397

TUNKEL, A. R. et al. The Management of Encephalitis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases, v. 47, n. 3, p. 303-327, 2008. DOI: 10.1086/589747

URCIUOLI, L. et al. Acute Ischemic Hemorrhagic Stroke in Two COVID-19 patients. J. infect. Dis. v. 74, n. 3, p. 249-251, 2021. DOI: 10.7883/yoken.JJID.2020.448

VACARAS, V. et al. Neurological complications in COVID-19 – a diagnostic challenge. J Med Life, v. 14, n. 2, p. 216-224, 2020. DOI: 10.25122/jml-2021-0045

VIRHAMMAR, J. et al. Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid. Neurology, v. 95, n. 10, p. 445-449, 2020. DOI: 10.1212/WNL.0000000000010250.

WANG, D. et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA, v. 323, n. 11, p. 1061 – 1069, 2020. DOI: 10.1001 / jama.2020.1585

WU, Y. et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun, v. 87, p. 18-22, 2020. DOI: 10.1016/j.bbi.2020.03.031

ZHENG, Y. Y. et al. COVID-19 and the cardiovascular system. Nature Reviews Cardiology, v. 17, p. 259-260, 2020. DOI: 10.1038/s41569-020-0360-5




DOI: https://doi.org/10.34117/bjdv7n10-009

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