Suplementação de coenzima Q10 e redução dos efeitos colaterais da terapêutica com estatinas: uma revisão sistemática / Coenzyme Q10 supplementation and reduction of side effects of statin therapy: a systematic review

Authors

  • Thaíssa Augusto da Silva Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Lara Gabriela de Araújo Cerqueira
  • Vitória Fernandes Freire de Melo
  • Thais Costa Machado Florence
  • Lana Mércia Santiago de Souza
  • Carine de Oliveira Sousa Bordallo
  • Joselita Moura Sacramento
  • Edilene Maria Queiroz Araújo

DOI:

https://doi.org/10.34117/bjdv7n8-600

Keywords:

Ubiquinone, Anticholesteremic Agents e Cholesterol.

Abstract

A coenzima Q10 (CoQ10), conhecida também como ubiquinona é um componente essencial da cadeia respiratória mitocondrial. Uma das causas da sua deficiência é o uso crônico de estatinas, classe de medicamentos anticolesterolêmicos largamente prescrito. Sua redução pode ocasionar efeitos colaterais indesejáveis, tais como dispneia, alterações hepáticas, sintomas musculares e/ou gastrointestinais, rabdomiólise, neuropatias periféricas, Diabetes Mellitus tipo 2, dentre outros.  Esta revisão literária objetivou entender se a suplementação de CoQ10 reduz os efeitos colaterais provocados pelo uso de estatinas, descrevê-los e indicar qual a dose segura e eficaz para o sucesso dessa estratégia nutricional. Trata-se de uma revisão sistemática da literatura, cuja busca se deu na base de dados MEDLINE/PubMed, de estudos publicados no período entre 2004 a 09/2020, com uso dos descritores e combinação Ubiquinone AND Anticholesteremic Agents e Ubiquinone AND Cholesterol. Foram identificados 462 artigos e após leitura do título, resumo e aplicação dos critérios de exclusão foram incluídos 18 trabalhos científicos para análise. Os estudos apresentaram população e metodologias variadas e os métodos de avaliação dos resultados também foram heterogêneos, principalmente devido a variedade de efeitos colaterais estudados. Dos 18 estudos, dez (66,6%) encontraram algum benefício da suplementação. Foi evidenciado que a dose usual de suplementação (entre 100 e 300 mg) foi capaz de trazer benefícios quanto aos seguintes parâmetros: função diastólica, endotelial e mitocondrial, fadiga, miopatias, dispneia, perda de memória, neuropatia periférica, perfil lipídico, atividade antioxidante e anti-inflamatória e hepatotoxicidade evidenciados a partir de 30 dias de suplementação e, ainda, a redução do risco cardiovascular.

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Published

2021-08-27

How to Cite

da Silva, T. A., Cerqueira, L. G. de A., de Melo, V. F. F., Florence, T. C. M., de Souza, L. M. S., Bordallo, C. de O. S., Sacramento, J. M., & Araújo, E. M. Q. (2021). Suplementação de coenzima Q10 e redução dos efeitos colaterais da terapêutica com estatinas: uma revisão sistemática / Coenzyme Q10 supplementation and reduction of side effects of statin therapy: a systematic review. Brazilian Journal of Development, 7(8), 84648–84672. https://doi.org/10.34117/bjdv7n8-600

Issue

Section

Original Papers