Doença Periodontal e sua prevenção utilizando biomarcador Poin-of-Care: uma revisão sistemática / Periodontal disease and targeted prevention using point-of-care oral fluid analytics: A systematic review

Alick Brianne Ribeiro Silva, Noemi de Oliveira Souto, Fernanda Maria Matos Aragão de Souza, Kathllen Milena Pereira Rocha, Matheus Silva de Andrade, Guilherme de Souza Alves Andrade, Juliane Pereira Butze

Abstract


A metaloproteinase-8 da matriz (MMP-8) é a colagenase mais proeminente encontrada nos tecidos periodontais inflamados. Sua forma ativa (aMMP-8) é cada vez mais utilizada como biomarcador para diagnóstico da doença periodontal. Portanto, o objetivo desta revisão sistemática foi avaliar a acurácia do POC (Point-of-Care) no diagnóstico e monitoramento da doença periodontal, analisando sua viabilidade e eficácia no uso clínico. Para isso, foi realizada uma revisão sistemática a partir dos bancos de dados PubMed/Medline, Web of Science, Science Direct, Scopus, Embase e Cochrane Collaboration Library. A estratégia de busca forneceu um total de 2.025 artigos nas diferentes bases de dados analisadas. Após a triagem por meio da leitura dos títulos e resumos, um total de 15 estudos foram considerados potencialmente elegíveis e lidos na íntegra pelos avaliadores. Ao final das análises, seis artigos publicados entre 2006 e 2021 atenderam a todos os critérios de inclusão e foram selecionados para a presente revisão sistemática. Concluiu-se que o futuro do POC para diagnosticar/monitorar a periodontite é promissor; no entanto, como acontece com qualquer nova tecnologia, importantes questões precisam ser abordadas antes de serem amplamente utilizadas em ambientes clínicos.


Keywords


Doença Periodontal, Periodontite, Diagnóstico, Biomarcadores. Metaloproteinase-8 da Matriz.

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DOI: https://doi.org/10.34117/bjdv7n7-227

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