Medicamentos inovadores para a pediatria: uma revisão da literatura / Innovative medicines for pediatrics: a review of the literature

Authors

  • Jéssica de Oliveira Mussel
  • Adriana Silveira Pereira de Melo
  • Marcia Maria Barros dos Passos
  • Mariana Sato de Souza Bustamante Monteiro

DOI:

https://doi.org/10.34117/bjdv7n7-222

Keywords:

Pediatria, Inovações Farmacotécnicas, Tecnologia Farmacêutica.

Abstract

Os pacientes pediátricos compõem um grupo heterogêneo e apresenta diversos desafios para os profissionais de saúde. Dentre eles está a escassez de medicamentos próprios para a pediatria, devido a diversos fatores que dificultam a Pesquisa e Desenvolvimento de novos medicamentos para este público, que como consequência, gera uma baixa adesão a algumas terapias medicamentosas. O objetivo deste trabalho foi identificar nas literaturas recentes novas formas farmacêuticas que atendam às necessidades do público pediátrico. Foi realizada uma revisão da literatura nas bases de dados PubMed, Science Direct, SciELO e Lilacs, no período de 2010 a 2021, utilizando as palavras chave “pediatric dosage forms”, “pediatric adherence”, “pediatric compliance”. Foram encontradas alternativas às formas farmacêuticas clássicas, como por exemplo: sistemas que simulam alimentos, como gelatinas, chocolates, pirulitos e gomas de mascar e formas impressas em três dimensões. As formas farmacêuticas que simulam alimentos apresentam como vantagem: semelhança visual e organoléptica com doces já conhecidos pelas crianças. Por sua vez, os sistemas impressos em três dimensões já contam com um representante incluído na Farmacopeia Americana e se destacam como uma inovação promissora, devido à possibilidade de serem produzidos utilizando qualquer geometria.

 

References

ANVISA. AGENCIA NACIONAL DE VIGILÂNCIA SANITÁRIA. Farmacopeia Brasileira, volume 2. 6ª Ed. Brasília, 2019.

ALI, A. A. et al. Pediatric drug development: formulation considerations. Drug Development and Industrial Pharmacy, Malásia, v. 40, n. 10, p. 1283-1299, 2014.

ALMURISI, S. H. et al. Formulation development of paracetamol instant jelly for paediatric use. Drug Development and Industrial Pharmacy, Malásia, v. 46, n. 8, p. 1373-1383, 2020.

AULTON, M. E; TAYLOR, K. M. G; Pharmaceutics: the design and manufacture of medicines. 4ª. Ed. Elsevier: Reino Unido, 2013.

BAR-SHALOM, D.; ROSE, K. Pediatric formulations: a roadmap. Nova Iorque: Springer, 2014.

BOATENG, J. Drug Delivery Innovations to Address Global Health Challenges for Pediatric and Geriatric Populations (through improvements in patient compliance). Journal of Pharmaceutical Sciences, Reino Unido, v. 106, n. 11, p. 3188-3198, 2017.

BOZTEPE, H. et al. Administration of oral medication by parents at home. Journal of Clinical Nursing, Reino Unido, v. 25, n. 21-22, 3345–3353, 2016.

CHEUNG, L. C. et al. Taste evaluation of a novel midazolam tablet for pediatric patients: In vitro drug dissolution, in vivo animal taste aversion and clinical taste perception profiles. International Journal of Pharmaceutics, Austrália, v. 535, n. 1-2, p. 194-200, 2018.

EUROPEAN MEDICINES AGENCY (Europa); Committee For Medicinal Products For Human Use. Reflection paper: formulations of choice for the paediatric population. Reino Unido, 2006.

GAUTHIER, P.; CARDOT, J. Developing Drugs for Children and the Adjustment of Medication—Is It a New Challenge or an Adaptation of Past Ideas? Journal of Personalized Medicine, França, v. 1, p. 5-16, 2011.

GUDZENKO, O. P. et al. The Invention of Drugs for Pediatrics: Reality and Prospects. The Pharma Innovation - Journal, Ucrânia, v. 2, n. 12, p. 36-41, 2014.

HEJAZ, H. A. et al. Development and characterization of paracetamol medicated lollipops. Pharmaceutical Technology in Hospital Pharmacy, Palestina, v. 5, n. 1, p.8, 2020.

IVANOVSKA, V. et al. Pediatric Drug Formulations: A Review of Challenges and Progress. Pediatrics, Holanda, v. 134, n. 2, p. 361-372, 2014.

JADHAV, A.; MOHITE, S. K. A Comprehensive Review On: Medicated Chewing Gum. Journal of Current Pharma Research, Índia, v. 4, n. 3, p. 1215-1224, 2014.

JAGADEESH, P. et al. Review of Medicated Lollipops. World Journal of Pharmaceutical Research, Índia, v. 6, n. 3, p. 399-405, 2017.

KAKINO, Y. et al. Gelation Factors of Pectin for Development of a Powder Form of Gel,

Dry Jelly, as a Novel Dosage Form. Chemical and Pharmaceutical Bulletin, Japão, v. 56, n. 11, p. 1035-1044, 2017.

KARAVASILI, C. et al. Pediatric-friendly chocolate-based dosage forms for the oral administration of both hydrophilic and lipophilic drugs fabricated with extrusion-based 3D printing. European Journal of Pharmaceutical Sciences, Grécia, v. 147, n. 105291, p. 10, 2020.

KAYE, J. L. Review of paediatric gastrointestinal physiology data relevant to oral drug delivery. International Journal of Clinical Pharmacy, Reino Unido, v. 33, n. 1, p. 20-24, 2011.

KHATUN, S. SUTRADHAR, K. B. Medicated chewing gum: An unconventional drug delivery system. International Current Pharmaceutical Journal, Bangladesh, v. 1, n. 4, p. 86-91, 2012.

KIM, K. H. et al. Bioavailability of the Common Cold Medicines in Jellies for Oral Administration. Pharmaceutics, Coreia do Sul, v. 12, n. 1073, p. 15, 2020.

KLINGMANN, V. et al. Favorable Acceptance of Mini-Tablets Compared with Syrup: A Randomized Controlled Trial in Infants and Preschool Children. The Journal of Pediatrics, Alemanha, v. 163, n. 6, p. 1728–1732, 2013.

MENEZES, V. A. et al. Pediatric medicines and their relationship to dental caries. Brazilian Journal of Pharmaceutical Sciences, Brasil, v. 46, n. 1, p. 157-164, 2010.

MOREIRA, M.; SARRAGUÇA, M. How can oral paediatric formulations be improved? A challenge for the XXI century. International Journal of Pharmaceutics, Portugal, v. 590, n. 119905, p. 9, 2020.

MONTERO-PADILLA, S. et al. Buccal Dosage Forms: General Considerations for Pediatric Patients. AAPS PharmSciTech, Chile, v. 18, n. 2, p. 273-282, 2016.

MOREIRA, M.; SARRAGUÇA, M. How can oral paediatric formulations be improved? A challenge for the XXI century. International Journal of Pharmaceutics, Portugal, v. 590, n. 119905, p. 9, 2020.

PAWAR, P. G. et al. Medicated chocolate and lollipops: a novel drug delivery system for pediatric patient. Pharma Science Monitor, v. 9, n. 1, p. 677-696, 2018.

PRASAD, L. K.; SMYTH, H. 3D Printing technologies for drug delivery: a review. Drug Development and Industrial Pharmacy, Estados Unidos da América, v. 42, n. 7, p. 1019-1031, 2015.

RAO, P. K. et al. Medicated lollipops for the treatment of oral thrush in children. International Journal of Life Sciences Biotechnology and Pharma Research, Índia, v. 1, n. 1, p. 95-102, 2012.

RATHOD, M. et al. Development and in-vitro evaluation of candy based medicated lollipops: a novel system of drug delivery. Journal of Drug Delivery and Therapeutics, Índia, v. 8, n. 4, p. 196-204, 2018.

SALMAN, S. et al. A novel, palatable paediatric oral formulation of midazolam: pharmacokinetics, tolerability, efficacy and safety. Anaesthesia, Austrália, v. 73, n. 12, p. 1469-1477, 2018.

SCOUTARIS, N. et al. 3D Printed “Starmix” Drug Loaded Dosage Forms for Paediatric Applications. Pharmaceutical Research, Reino Unido, v. 35, n. 34, p. 1-11, 2017.

SEMWAL, R. et al. Chewing Gum: A Novel Approach for Drug Delivery. The Journal of Applied Research, India, v. 10, n. 3, p. 124-132, 2010.

STRICKLEY, R. G. Pediatric Oral Formulations: An Updated Review of Commercially

Available Pediatric Oral Formulations Since 2007. Journal of Pharmaceutical Sciences, Estados Unidos da América, v. 108, p. 1335-1365, 2019.

SYNARIDOU, M. S. et al. Innovative Pediatric Formulations: Ibuprofen in Chocolate-Coated Honey Core. Journal of Pharmaceutical Innovation, Grécia, v. 12, p. 404-415, 2020.

TANGSO, K. J. et al. Confectionery-based Dose Forms. Current Drug Delivery, Austrália, v. 12, n. 1, p. 56-62, 2015.

THABET, Y. et al. Drug Formulations: Standards and Novel Strategies for Drug Administration in Pediatrics. The Journal of Clinical Pharmacology, Alemanha, v. 58, n. 10, p. s26-s35, 2018.

TROFIMIUK, M. et al. How to Modify Drug Release in Paediatric Dosage Forms? Novel Technologies and Modern Approaches with Regard to Children’s Population. International Journal of Molecular Sciences, Polônia, v. 20, n. 13, p. 1-22, 2019.

ZIESCHANG, L. et al. Formulation development of medicated chewing gum tablets by direct compression using the SeDeM-Diagram-Expert-System. European Journal of Pharmaceutics and Biopharmaceutics, Alemanha, v. 144, p. 68-78, 2019.

Published

2021-07-09

How to Cite

Mussel, J. de O., de Melo, A. S. P., dos Passos, M. M. B., & Monteiro, M. S. de S. B. (2021). Medicamentos inovadores para a pediatria: uma revisão da literatura / Innovative medicines for pediatrics: a review of the literature. Brazilian Journal of Development, 7(7), 69403–69423. https://doi.org/10.34117/bjdv7n7-222

Issue

Section

Original Papers