Glaucoma de pressão normal: uma revisão integrativa e seus Tratamentos / Low tension glaucoma: an integrative review

Amanda Cypreste Alves Batista, Bruna Alves Melo de Souza, Carolina de Paula Mangussi, Fernando Rafael da Cunha Chagas, Rafael Dalton Machado, Gabriel Augusto Silva Côrtes, Mariane de Oliveira Diogo Scussel, Izabela De Maria Aburachid, Ciro Peixoto Vasconcelos, Marcella Moreira Madeira, Victor Resende Vaz de Melo

Abstract


INTRODUÇÃO: O glaucoma de pressão normal (GPN) é uma neuropatia óptica progressiva que possui a pressão intraocular (PIO) dentro da faixa de normalidade (≤ 21 mmHg). Na prática clínica, a base do tratamento do GPN é a redução da PIO, entretanto, aproximadamente 50% dos pacientes ainda apresentam perda de campo visual apesar de baixos valores da PIO. METODOLOGIA: Pesquisa de coletas de dados de artigos e ensaios clínicos randomizados na plataforma PubMed, utilizando os descritores: “Glaucoma” e “Low Tension Glaucoma”. RESULTADOS: Houve eficácia de medidas terapêuticas farmacológicas ou não sobre a redução da PIO (18 estudos). Todos que abordaram a cirurgia concordam que esta reduz a PIO. Sobre terapia farmacológica, todos confirmam que os fármacos estudados reduzem a PIO. CONCLUSÃO: As medidas farmacológicas, quanto as cirurgias anti-glaucomatosas são eficazes em reduzir a PIO.


Keywords


Glaucoma, Glaucoma de pressão normal, revisão

References


Barranco Esporcatte, B et al. Glaucoma de pressão normal: atualização. Arquivos Brasileiros de Oftalmologia, 2016;79(4):270-276.

Killer, HE et al. Normal tension glaucoma: review of current understanding and mechanisms of the pathogenesis. Eye: The Scientific Journal of The Royal College of Ophthalmologists, 2018;32:924–930.

Chen, M. Normal tension glaucoma in Asia: Epidemiology, pathogenesis, diagnosis, and management. Taiwan Journal of Ophthalmology, 2020;10(4):250–254.

Suominen S, Harju M, Kurvinen L, et al. Deep sclerectomy in normal-tension glaucoma with and without Mitomycin-c. Acta Ophthalmol. 2013;92(7):701–706.

Harju M, Suominen S, Allinen P, et al. Long-term results of deep sclerectomy in normal-tension Glaucoma. Acta Ophthalmol. 2018;96(2):154–60. Best UP, Domack H, Schmidt V, Khalifa M. Microinvasive glaucoma surgery-Efficacy of trabecular stents in combined interventions: A clinical study on 65 eyes. Ophthalmology. 2019;116:771–779.

Aihara M, Kuwayama Y, Miyata K, Ohtani S, Ideta R, Hashimoto Y, Sasaki N, Shirato S. Twelve-month efficacy and safety of glaucoma filtration device for surgery in patients with normal-tension glaucoma. Jpn J Ophthalmol. 2019 Sep;63(5):402-409.

Kiddee W., Atthavuttisilp S. The effects of selective laser trabeculoplasty and travoprost on circadian intraocular pressure fluctuations: a randomized clinical trial. Medicine. 2017;96

Guo X., Kong X., Huang R., Jin L., Ding X., He M., Liu X., Patel M.C., Congdon N. Effect of Ginkgo Biloba on Visual Field and Contrast Sensitivity in Chinese Patients With Normal Tension Glaucoma: A Randomized, Crossover Clinical Trial. Investig. Opthalmol. Vis. Sci. 2014;55:110–116

Park J.W., Kwon H.J., Chung W.S., Kim C.Y., Seong G.J. Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma. Korean J. Ophthalmol. 2011;25:323–328.

Araie M., Shirato S., Yamazaki Y., Matsumoto C., Kitazawa Y., Ohashi Y. Risk factors for progression of normal-tension glaucoma under β-blocker monotherapy. Acta Ophthalmologica. 2012;90(5):e337–e343.

Kim M, Kim DM, Park KH, Kim T-W, Jeoung JW, Kim SH. Intraocular pressure reduction with topical medications and progression of normal-tension glaucoma: a 12-year mean follow-up study. Acta Ophthalmol (Copenh). 2013;91(4):e270–275.

Kim JM, Kim TW, Kim CY, Kim HK, Park KH. Comparison of the intraocular pressure-lowering effect and safety of brimonidine/timolol fixed combination and 0.5% timolol in normal-tension glaucoma patients. Jpn J Ophthalmol. 2016 Jan;60(1):20–26.

Park SH, Yoo SH, Ha SJ. Comparison of ocular pulse amplitude-lowering effects of tafluprost and latanoprost by dynamic contour tonometry. J Ocul Pharmacol Ther. 2015;31(10):617–622.

Mizoue S, Nitta K, Shirakashi M, Nitta A, Yamabayashi S, Kimura T, Ueda T, Takeda R, Matsumoto S, Yoshikawa K. Multicenter, Randomized, Investigator-Masked Study Comparing Brimonidine Tartrate 0.1% and Timolol Maleate 0.5% as Adjunctive Therapies to Prostaglandin Analogues in Normal-Tension Glaucoma. Adv Ther. 2017 Jun;34(6):1438-1448.

De Moraes CG, Liebmann JM, Greenfield DS, Gardiner SK, Ritch R, Krupin T (2012) Risk factors for visual field progression in the low-pressure glaucoma treatment study. Am J Ophthalmol 154:702–711.

Galose MS, Elsaied HM, Macky TA, Fouad PH. Brinzolamide/timolol versus dorzolamide/timolol fixed combinations: a hospital-based, prospective, randomized study. Indian J Ophthalmol. 2016;64:127–131.

Shoji T, Sato H, Mizukawa A, Hirota N, Enoki T, Kojima T, Kanda T, Takeuchi M. Hypotensive effect of latanoprost/timolol versus travoprost/timolol fixed combinations in NTG patients: A randomized, multicenter, crossover clinical trial. Invest Ophthalmol Vis Sci. 2013;54:6242–6247.

Suzuki K, Otsuka N, Hizaki H, et al; Tafluprost/Timolol Versus Latanoprost/Timolol (TTVLT) Study Group. Multicenter, randomized, controlled study comparing tafluprost/timolol fixed combination with latanoprost/timolol fixed combination in primary open-angle glaucoma and ocular hypertension. Adv Ther. 2018;35:796–808.

Lee NY, Park HY, Park CK. Comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and ocular perfusion pressure in patients with normal-tension glaucoma: a randomized, crossover clinical trial. PLoS One. 2016;12(11):1–16.

Lee NY, Park HL, Park CK. Effects of a dorzolamide/timolol fixed combination on diurnal intraocular pressure, heart rate, blood pressure, and ocular perfusion pressure in normal-tension glaucoma. Jpn J Ophthalmol. 2016

Kiddee W., Atthavuttisilp S. The effects of selective laser trabeculoplasty and travoprost on circadian intraocular pressure fluctuations: a randomized clinical trial. Medicine. 2017;96

Costagliola C., Romano M.R., dell’Omo R., Russo A., Mastropasqua R., Semeraro F. Effect of palmitoylethanolamide on visual field damage progression in normal tension glaucoma patients: Results of an open-label six-month follow-up. J. Med. Food. 2014;17:949–954.

Liu H, Yang D, Ma T, Shi W, Zhu Q, Kang J, Wang N. Measurement and Associations of the Optic Nerve Subarachnoid Space in Normal Tension and Primary Open-Angle Glaucoma. Am J Ophthalmol. 2018;186:128–137.

Furlanetto RL, de Moraes CG, Teng CC, Liebman JM, Greenfield DS, Gardiner SK, et al. Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study. Am J Ophthalmol. 2014;157:945–52.

Jeong JH, Park KH, Jeoung JW, Kim DM. Preperimetric normal tension glaucoma study: long-term clinical course and effect of therapeutic lowering of intraocular pressure. Acta Ophthalmol. 2014;92:e185–193.

Suominen S, Harju M, Ihanamaki T, Vesti E. The effect of deep sclerectomy on intraocular pressure of normal-tension glaucoma patients: 1-year results. Acta Ophthalmol. 2010;88:27–32.

Lachkar Y, et al. Nonpenetrating deep sclerectomy: a 6-year retrospective study. Eur J Ophthalmol. 2004;14:26–36.

Jong LD, et al. Five-year extension of a clinical trial comparing the EX-PRESS glaucoma filtration device and trabeculectomy in primary open-angle glaucoma. Clin Ophthalmol. 2011;5:527-533.

Kato N, et al. Indications and postoperative treatment for Ex-PRESS® insertion in Japanese patients with glaucoma: comparison with standard trabeculectomy. Clin Ophthalmol. 2015;9:1491-1498.

Marzette L, Herndon LW. A comparison of the Ex-PRESS™ mini glaucoma shunt with standard trabeculectomy in the surgical treatment of glaucoma. Ophthalmic Surg Lasers Imaging. 2011; 42:453-459.

Li T, et al. Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis. Ophthalmology. 2016; 123: 129-140.

Sena SF, Lindsley K. Neuroprotection for treatment of glaucoma in adults. Cochrane Database Syst Rev. 2017; 1 :CD006539.

Martins, Saulo Costa et al. Nível de conhecimento sobre glaucoma primário de ângulo aberto entre os estudantes de medicina. Revista Brasileira de Oftalmologia [online]. 2014, v. 73, n. 5 [Acessado 25 Junho 2021] , pp. 302-307.




DOI: https://doi.org/10.34117/bjdv7n7-134

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