Manifestações Neurológicas em Pacientes que Contraíram Covid-19: uma revisão integrativa da literatura / Neurological Manifestations in Patients Who Contracted Covid-19: an integrative literature review

Jhonson Tizzo Godoy, Milla Giancristofaro Dutra, Alexandre Antonio Agnolin, Ana Teresa Bittencourt Avila, Carolina Bohn Faccio, Elaine Maria Souza, Giovana Lima de Almeida, Karen Karollinne Dikauá Santos Feitosa, Larissa Magalhães de Moraes Lopes, Maria Luiza Franco de Oliveira, Sthefanie Ferreira Caires Aguiar

Abstract


INTRODUÇÃO: O espectro da infecção do SARS-CoV-2 é amplo e predomina o acometimento respiratório. Estudos recentes, no entanto, têm demonstrado cada vez mais o acometimento extra respiratório, incluindo alterações neurológicas diversas. A presente revisão discorre sobre as principais manifestações neurológicas decorrentes da infecção por SARS-CoV-2 e suas consequências para os infectados. METODOLOGIA: Trata-se de uma revisão integrativa da literatura. As bases de dados utilizadas foram MEDLINE/PubMed, Scielo e LILACS. Os seguintes descritores foram utilizados: “Neurological manifestations”, “COVID-19” e “Neurological symptoms”. RESULTADOS: No mundo foram reportadas diversas manifestações neurológicas como as centrais (cefaleia, tontura, convulsões, meningite/encefalite, déficit cognitivo, AVC), periféricas  (analgesia, anosmia) e musculoesqueléticas. As mais frequentemente observadas foram tontura e cefaléia. DISCUSSÃO: O mecanismo de neuro invasão ainda não está totalmente esclarecido, mas as evidências mostram que se deve haver lesão direta, imunomediada ou decorrente de hipóxia, além de eventos secundários relacionados a distúrbios sistêmicos, como sepse, hiperpirexia  hipercoagulabilidade etc. A agressividade dos sintomas pode variar desde as mais leves até predispor manifestações graves como doenças cerebrovasculares agudas. CONCLUSÃO: As  manifestações neurológicas apresentaram-se sob diferentes formas e ainda são necessários mais  ensaios clínicos para analisar a fisiopatologia do SARS-CoV-2 no sistema nervoso, assim como suas consequências tardias.


Keywords


COVID-19, SARS-CoV-2, Manifestações Neurológicas, Infecções por Coronavírus.

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DOI: https://doi.org/10.34117/bjdv7n7-115

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