Dynamic analysis of the immunological response of Balb/c mice with experimental breast cancer submitted to immunotherapy treatment of dendritic cell/ Análise dinâmica da resposta imunológica de camundongos Balb/c com câncer de mama experimental submetido a imunoterapia de células dendríticas

Authors

  • Marcia Antoniazi Michelin Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Eddie Fernando Cândido Murta
  • Saulo Fernando Moreira da Silva

DOI:

https://doi.org/10.34117/bjdv7n7-101

Keywords:

dendritic cell immunotherapy, breast cancer, active immunotherapy.

Abstract

INTRODUCTION: Cancer is a complex disease because it is capable of inhibiting the immune response through tumor escape mechanisms. OBJECTIVE: analyze the dynamics of the immune system during cancer treatment with dendritic cell immunotherapy. We evaluated the presence of tumor infiltrate of CD8 T lymphocytes, transcription factors of CD4 T lymphocytes in the spleen of these animals, the development of tumor volume and the behavior of coestimulatory molecules.  METHODS: 70 female Balb/c mice were divided into experimental and control groups, they were evaluated on the 7th e 14th days after tumor challenge and dendritic cell immunotherapy. RESULTS: Molecules such as T-bet, showed an increased expression in treated tumor group. Our results also demonstrated the higher MFI of CD8 + T lymphocytes infiltrate in the treated groups. Thus, there is a greater MFI of protumoral co-stimulatory molecules such as CTLA4 in the untreated groups. CONCLUSION: the immune system is able to modulate an immune response against tumor within 14 days if the organism is being treated with dendritic cell immunotherapy.

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Published

2021-07-06

How to Cite

Michelin, M. A., Murta, E. F. C., & Silva, S. F. M. da. (2021). Dynamic analysis of the immunological response of Balb/c mice with experimental breast cancer submitted to immunotherapy treatment of dendritic cell/ Análise dinâmica da resposta imunológica de camundongos Balb/c com câncer de mama experimental submetido a imunoterapia de células dendríticas. Brazilian Journal of Development, 7(7), 66648–66666. https://doi.org/10.34117/bjdv7n7-101

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Original Papers