Terapia fotodinâmica para o tratamento das lesões orais: revisão de literatura / Photodynamic therapy for the treatment of oral lesions: literature review

Authors

  • Beatriz Jefres Lima De Sousa Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Julyana Almeida Do Nascimento
  • Myrla Nathalia Almeida Motta
  • Guilherme Candido do Espírito Santo Rocha
  • Andrezza Lauria de Moura
  • Giorge Pessoa de Jesus
  • Kaline de Moura Silva

DOI:

https://doi.org/10.34117/bjdv7n6-164

Keywords:

Laser de Baixa Potência, Terapia Fotodinâmica, Patologia Bucal.

Abstract

Introdução: A terapia fotodinâmica (PDT, do inglês photodynamic therapy) é um método que utiliza um agente fotossensibilizador ativado por uma fonte de luz, através de um comprimento de onda específico onde essa reação provoca a liberação de oxigênio reativo capazes de danificar a parede celular e matar certos tipos de células. Objetivo: realizar uma revisão integrativa da literatura sobre o uso da laserterapia de baixa intensidade relacionada à terapia fotodinâmica no tratamento das lesões bucais e a importância desta temática na odontologia como uma opção terapêutica não invasiva. Materiais e Métodos: Foi realizado uma revisão de literatura usando os meios de pesquisa com o Pubmed, SciELO, Lilacs e Google Acadêmico, com os termos: “PDT na odontologia, terapia fotodinâmica, laserterapia de baixa intensidade, lesões orais, laser azul de metileno, laser em odontologia” e suas respectivas traduções para língua inglesa. Os critérios de inclusão foram artigos publicados nas línguas inglesa e portuguesa a partir do ano de 2010 e que abordassem a temática proposta. Os critérios de exclusão foram artigos que não fossem publicados em português ou inglês, trabalhos de conclusão de curso, monografias, dissertações, teses e publicações que não contivessem o texto completo disponível. Resultados: analisou-se 53 artigos que, atenderam aos critérios previamente estabelecidos. A síntese dos dados extraídos foi apresentada de forma descritiva, reunindo-a ao conhecimento produzido sobre o tema investigado nesta revisão. Concluiu-se que a PDT apresenta indícios positivos no processo de cicatrização e reparo tecidual, e o progressivo uso na odontologia, traz consigo uma tendência para novas pesquisas, com esperança de agentes fototerapêuticos mais seletivos.

References

Eduardo CP, Bello-Silva MS, Ramalho, KM, Lee, EMR, Aranha, AC. A terapia fotodinâmica como benefício complementar na clínica odontológica. Rev. Assoc. Paul. Cir. Dent. 2015; 69(3):226-235.

Lins RDAU, Dantas EM, Lucena KCR, Catão MHCV, Granville-Garcia AF, Carvalho NTG. Biostimulation effects of low-power laser in the repair process. An. Bras. Dermatol. 2010; 85(6): 849-855.

Kathuria V, Dhillon JK, Kalra G. Low Level Laser Therapy: A Panacea for oral maladies. Laser Ther. 2015; 24(3):215-23.

Rumão WL, Valdrighi HC, Furletti VF, Gouvêa GR, Santamaria-Jr M. Influence of photobiomodulation on pain perception during initial orthodontic tooth movement. Rev. odontol. UNESP [Internet]. 2020; 9: e20200003.

Silva DC, Freitas PM, Calvo AFC, Gimenez T, Zanola M, Imparato JCP. Treatment of Riga-Fede disease using laser therapy: clinical case report. RGO, Rev. Gaúch. Odontol. [Internet].2017; 65(1): 87-91.

Albrektson M, Hedstrom L, Berg H. Recurrent aphthous stomatitis and pain management with low-level laser therapy: a randomized controlled trial. Oral surg oral med oral pathol oral radiol. 2014; 117 (5): 590-594.

Lins RDAU, Dantas EM, Lucena KCR, Catão MHCV, Granville-Garcia AF, Carvalho NTG. Biostimulation effects of low-power laser in the repair process. An. Bras. Dermatol. 2010; 85(6): 849-855.

Marinick K, Manoil D, Filieri A, Wataha JC, Schrenzel J, Lange N, Bouillague S. Repeated exposures to blue light--activated eosin y enhance inactivation of e. Faecalis bio-films, in vitro. Photodiagnosis and photodynamic therapy, 2015; 12 (3): 393-400.

Lima SP, Sousa ETD, Melo MO, Silva MS. Photodynamic therapy as an aiding in the endodontic treatment: case report. RGO, Rev. Gaúch. Odontol. 2019; 67: e20190030.

Qamar Z, Bamousa B, AlSheikh R, Ali S, Baeshen HÁ, Noushad, M, Niazi, et al. A bibliometric review of top 50 cited articles published in the Photodiagnosis and Photodynamic Therapy from 2004 to 2019. Photodiagnosis and Photodynamic Therapy. 2020;31: 101927.

Pra?mo EJ, Kwa?ny M, ?api?ski M, Mielczarek A. Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases. Adv Clin Exp Med. 2016;25(4):799-807.

Issa MCA, Manela-Azulay M. Terapia fotodinâmica: revisão da literatura e documentação iconográfica. An. Bras. Dermatol. 2010; 85(4): 501-511.

Castano AP, Demidova TN, Hamblin MR. Mechanisms in photodynamic therapy: part two-cellular signaling, cell metabolism and modes of cell death. Photodiagnosis Photodyn Ther. 2005;2(1):1-23.

Leite DP, Paolillo FR, Parmesano TN, Fontana CR, Bagnato VS. Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial. Photomedicine and Laser Surgery. 2014 ;32(11):627-632.

Mileto TN, Azambuja FG. Low-intensity laser efficacy in postoperative extraction of third molars. RGO, Rev. Gaúch. Odontol. 2017; 5(1): 13-19

Nabi S, Amin K, Masoodi A, Farooq R, Purra AR, Ahangar FA. Effect of preoperative ibuprofen in controlling postendodontic pain with and without low-level laser therapy in single visit endodontics: A randomized clinical study. Indian J Dent Res. 2018 Jan-Feb;29(1):46-50.

Ribeiro GH, Chrun Emanuely S, Dutra KL., Daniel FI., Grando LJ. Osteonecrose da mandíbula: revisão e atualização em etiologia e tratamento. Braz. j. otorhinolaryngol. 2018; 84(1): 102-108.

Cavalcanti TM, Almeida-Barros RQ, Catão MHCV, Feitosa APA, Lins RDAU. Conhecimento das propriedades físicas e da interação do laser com os tecidos biológicos na odontologia. An. Bras. Dermatol. 2011; 86(5): 955960.

Campos ACL, Borges-Branco A, Groth AK. Cicatrização de feridas. ABCD, Arq. Bras. Cir. dig. 2007; 20(1):51-58.

Silva Neto JM de A, Santos JKB dos, Gomes NMA, Silva CC de C, Almeida Barros JVBAR, Medeiros MLBB. Aplicação da laserterapia de baixa intensidade na odontologia: revisão integrativa. REAS. 2020; 39:e2142.

Soliman M, Eldwakhly E, Aldegheishem A, Binobaid A, Saadaldin S. Familiarity and implementation of academicians of dental schools regarding the application of photodynamic therapy. Photodiagnosis and Photodynamic Therapy. 2020; 31: 101897.

Majewski M; Jorge AOC; Junqueira JC. Efeitos da terapia fotodinâmica antimicrobiana em leveduras do gênero Cândida. Rev Ciênc Farm Básica Apl., 2014;35(4):663-669.

Kwiatkowski S, Knap B, Przystupski D, Saczko J, K?dzierska E, Knap-Czop K, Kotli?ska J, Michel O, Kotowski K, Kulbacka J. Photodynamic therapy - mechanisms, photosensitizers and combinations. Biomed Pharmacother. 2018; 106:1098-1107.

Abrahamse H, Hamblin MR. New photosensitizers for photodynamic therapy. Biochem J. 2016;473(4):347-64.

Andrade FSSD, Clark RMO, Ferreira ML. Effects of low-level laser therapy on wound healing. Rev. Col. Bras. Cir. 2014; 41(2): 129-133.

Reginato E, Wolf P, Hamblin MR. Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects. World J Immunol. 2014;4(1):1-11.

Cruz PM, Mo H, McConathy WJ, Sabnis N, Lacko AG. The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics. Front Pharmacol. 2013;25(4):119.

Hamblin MR, Chiang LY, Lakshmanan S, Huang YY, Garcia-Diaz M, Karimi M, de Souza Rastelli AN, Chandran R. Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School. Nanotechnol Rev. 2015;4(4):359-372.

Nowak-Stepniowska A, Pergo? P, Padzik-Graczyk A. Metoda fotodynamiczna diagnostyki i leczenia nowotworów--mechanizmy i zastosowania [Photodynamic method of cancer diagnosis and therapy--mechanisms and applications]. Postepy Biochem. 2013;59(1):53-63.

Lee YE, Kopelman R. Polymeric nanoparticles for photodynamic therapy. Methods Mol Biol. 2011;726: 151-78.

Robertson CA, Evans DH, Abrahamse H. Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. J Photochem Photobiol B. 2009;96(1):1-8.

Stapleton M, Rhodes LE. Photosensitizers for photodynamic therapy of cutaneous disease. J Dermatolog Treat. 2003; 14(2):107-12.

Berdugo M, Bejjani RA, Valamanesh F, Savoldelli M, Jeanny JC, Blanc D. et al. Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes. Investigative Ophthalmology & Visual Science. 2008;49(4):1633-1644.

Saavedra R, Rocha LB, D?browski JM, Arnaut LG. Modulation of biodistribution, pharmacokinetics, and photosensitivity with the delivery vehicle of a bacteriochlorin photosensitizer for photodynamic therapy. ChemMedChem. 2014; 9(2):390-8.

Huang L, Krayer M, Roubil JG, et al. Stable synthetic mono-substituted cationic bacteriochlorins mediate selective broad-spectrum photoinactivation of drug-resistant pathogens at nanomolar concentrations. Journal of Photochemistry and photobiology. B, Biology. 2014 Dec; 141:119-127.

Späth A, Leibl C, Cieplik F, Lehner K, Regensburger J, Hiller KA, Bäumler W, Schmalz G, Maisch T. Improving photodynamic inactivation of bacteria in dentistry: highly effective and fast killing of oral key pathogens with novel tooth-colored type-II photosensitizers. J Med Chem. 2014 Jun 26;57(12):5157-68.

Harris F, Sayed Z, Hussain S, Phoenix DA. An investigation into the potential of phenothiazinium-based photo-sensitisers to act as PDT agents. Photodiagnosis Photodyn Ther. 2004 Nov;1(3):231-9.

Jiang C, Yang W, Wang C, Qin W, Ming J, Zhang M, Qian H, Jiao T. Methylene Blue-Mediated Photodynamic Therapy Induces Macrophage Apoptosis via ROS and Reduces Bone Resorption in Periodontitis. Oxid Med Cell Longev. 2019 Aug 14;2019:1529520.

Volpato LER, Silva TC, Oliveira TM, Sakai VT, Machado MAAM. Mucosite bucal rádio e quimioinduzida. Rev. Bras. Otorrinolaringol. [Internet]. 2007; 73(4): 562-568.

Kathuria V, Dhillon JK, Kalra G. Low Level Laser Therapy: A Panacea for oral maladies. Laser Ther. 2015 Oct 2;24(3):215-23. doi: 10.5978/islsm.15-RA-01. PMID: 26557737; PMCID: PMC4639680.

Medeiros-Filho JB, Maia Filho EM, Ferreira MC. Laser and photochemotherapy for the treatment of oral mucositis in young patients: Randomized clinical trial. Photodiagnosis Photodyn Ther. 2017 Jun;18:39-45. doi: 10.1016/j.pdpdt.2017.01.004. Epub 2017 Jan 16. PMID: 28093356.

Pinheiro SL, Bonadiman AC, Borges Lemos ALDA, Annicchino BM, Segatti B, Pucca DS, Dutra PT, de Carvalho E Silva RM, Leal F. Photobiomodulation Therapy in Cancer Patients with Mucositis: A Clinical Evaluation. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):142-150. doi: 10.1089/photob.2018.4526. Epub 2019 Feb 20. PMID: 31050952.

Lins DACP; Santos TKGL dos. O uso da terapia fotodinâmica como tratamento complementar na candidíase oral. Arch Health Invest. 2018; 7 (5): 1

Freire, F., Ferraresi, C., Jorge, A. O. C., & Hamblin, M. R. (2016). Photodynamic therapy of oral Candida infection in a mouse model. Journal of Photochemistry and Photobiology B: Biology, 159, 161–168. doi:10.1016/j.jphotobiol.2016.03.049

Carmello JC, Alves F, Basso FG, de Souza Costa CA, Tedesco AC, Lucas Primo F, Mima EGO, Pavarina AC. Antimicrobial photodynamic therapy reduces adhesion capacity and biofilm formation of Candida albicans from induced oral candidiasis in mice. Photodiagnosis Photodyn Ther. 2019 Sep; 27: 402-407. doi: 10.1016/j.pdpdt.2019.06.010. Epub 2019 Jul 5. PMID: 31284075.

Teodoro P, Fernandes HV. O uso da terapia fotodinâmica como método alternativo de tratamento da candidíase oral. Revista Arquivos Científicos (IMMES) [Internet]. 18jun.2020; 3(1):14-3.

Canto AM, Müller H, Freitas RR de, Santos PSS. Líquen plano oral (LPO): diagnóstico clínico e complementar. An. Bras. Dermatol. [Internet]. 2010. Oct; 85(5): 669-675.

Jajarm HH, Falaki F, Sanatkhani M, Ahmadzadeh M, Ahrari F, Shafaee H. A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial. Lasers Med Sci. 2015 Jul;30(5):1475-80. doi: 10.1007/s10103-014-1694-1. Epub 2014 Dec 9. PMID: 25487185.

Rakesh N, Clint JB, Reddy SS, Nagi R, Chauhan P, Sharma S, Sharma P, Kaur A, Shetty B, Ashwini S, Pavan Kumar T, Vidya GS. Clinical evaluation of photodynamic therapy for the treatment of refractory oral Lichen planus - A case series. Photodiagnosis Photodyn Ther. 2018 Dec; 24:280-285. doi: 10.1016/j.pdpdt.2018.09.011. Epub 2018 Sep 24. PMID: 30261326.

Hoseinpour Jajarm H, Asadi R, Bardideh E, Shafaee H, Khazaei Y, Emadzadeh M. The effects of photodynamic and low-level laser therapy for treatment of oral lichen planus-A systematic review and meta-analysis. Photodiagnosis Photodyn Ther. 2018 Sep;23: 254-260. doi: 10.1016/j.pdpdt.2018.07.001. Epub 2018 Jul 10. PMID: 30006319.

Raguse JD, Hossamo J, Tinhofer I, Hoffmeister B, Budach V, Jamil B, Jöhrens K, Thieme N, Doll C, Nahles S, Hartwig ST, Stromberger C. Patient and treatment-related risk factors for osteoradionecrosis of the jaw in patients with head and neck cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar;121(3):215-21.doi: 10.1016/j.oooo.2015.10.006. Epub 2015 Oct 22. PMID: 26703417.

Pedroni ACF, Miniello TG, Hirota C, Carvalho MH, Lascala CA, Marques MM, Very local application of photodynamic and photobiomodulating antimicrobial therapies to control osteoradionecrosis and xerostomia after treatment of laryngeal carcinoma: case report of oral rehabilitation complete. Photodiagnosis and photodynamic therapy. 2020 Sep; 31: 101835. doi: https://doi.org/10.1016/j.pdpdt.2020.1018

Ribeiro Guilherme Henrique, Minamisako Mariana Comparotto, Rath Inês Beatriz da Silva, Santos Aira Maria Bonfim, Simões Alyne, Pereira Keila Cristina Rausch et al. Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy. J. Appl. Oral Sci. 2018; 26: e20170172.

Published

2021-06-09

How to Cite

De Sousa, B. J. L., Do Nascimento, J. A., Motta, M. N. A., Rocha, G. C. do E. S., de Moura, A. L., de Jesus, G. P., & Silva, K. de M. (2021). Terapia fotodinâmica para o tratamento das lesões orais: revisão de literatura / Photodynamic therapy for the treatment of oral lesions: literature review. Brazilian Journal of Development, 7(6), 56229–56246. https://doi.org/10.34117/bjdv7n6-164

Issue

Section

Original Papers