Novos conceitos na dermatite atópica em cães – revisão de literatura / New concepts in atopic dermatitis in dogs – review

Millena Leme de Campos, Leila Cristina da Silva, Jonas Moraes-Filho

Abstract


A Dermatite Atópica (DA) é uma enfermidade alergo-inflamatória de caráter crônico da pele e orelha externa de cães e gatos, ocorrendo principalmente em jovens adultos de raça definida. É uma enfermidade multifatorial resultante de uma interação entre fatores ambientais e genéticos. Ambos os fatores podem criar uma função alterada da barreira epidérmica e da resposta imunológica em pacientes predispostos. O prurido é o principal sintoma da DA canina. A sua intensidade pode manifestar-se por várias formas como: coçar, morder, lamber ou esfregar. Com a evolução da doença, o período do prurido aumenta de forma gradual, tornando-se perene e generalizado. A doença tem seu diagnóstico estabelecido apenas por critérios clínicos que incluem: histórico compatível, sintomas e sinais compatíveis e pela exclusão de outras causas de dermatopatias descartadas pela anamnese, pelo exame físico, ou ainda pelo resultado de exames complementares e tentativas terapêuticas. Frequentemente necessita de tratamento com intervenções farmacológicas. Por se tratar de uma doença incurável, com manifestações e complicações variáveis, é imperativo que o clínico explique aos tutores todas as formas possíveis de tratamento, detalhando índices de sucesso, custo e efeitos colaterais. Essa revisão disponibiliza de forma prática, os novos conceitos de patogênese e critérios diagnósticos da doença, além dos seus avanços terapêuticos.


Keywords


Dermatite, Atopia, Prurido, Cães

References


ACKERMAN, L. Canine allergic disorders. In: NESBITT, G.H.; ACKERMAN, L. Canine and feline dermatology: Diagnosis and Treatment. Veterinary Learning Systems, p. 110-120, 1998.

ALEO, M.; MAHABIR, S.; BAINBRIDGE, G. et al. Comparison of effects of Lokivetmab versus prednisolone on intradermal testing in Dermatophagoides farinae sensitized beagles (Abstract). Veterinary Dermatology, v. 27, p. 74, 2006.

BERNSTEIN, J.A. et al. Hair and saliva analysis fails to accurately identify atopic dogs or differentiate real and fake samples. Veterinary Dermatology, v. 30, p. 105-e28, 2019.

BREMENT, T.; LALY, M.J.; CAMBARROS, D.; GUILLEMAILLE, D.; BOURDEAU, P.J.; BRUET, V. Reliability of different sets of criteria in diagnosing canine atopic dermatitis applied to a population of 250 dogs seen in a veterinary teaching hospital. Veterinary Dermatology, v. 30, p. 188e-59, 2019.

BOTONI, L.S. et al. Comparison of demographic data, disease severity and response to treatment, between dogs with atopic dermatitis and atopic-like dermatitis: a retrospective study. Veterinary Dermatology, v. 30, p. 10-e4, 2019.

CARLOTTI, D.N. Allergen specific hyposensitization and other means of treating canine atopic dermatitis. Proceedings of the 5th world congress of veterinary dermatology, p. 132-141, 2004.

CARMI-LEVY, I.; HOMEY, B.; SOUMELIS, V.A. A modular view of cytokine networks in atopic dermatitis. Clinical Reviews in Allergy & Immunolology, v. 41, p. 245-253, 2011.

CHAUDHARY, S.K.; SINGH, S.K.; KUMARI, P.; KANWAL, S.; SOMAN, S.K.; CHOUDHURY, S.; GARG, S.K. Alterations in circulating concentrations of IL-17, IL-31 and total IgE in dogs with atopic dermatitis. Veterinary Dermatology, 2019.

COSGROVE, S.B.; CLEAVER, D.M; KING, V.L. et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Veterinary Dermatology, v. 26, p. 171-179, 2015.

CUNHA, V.; LIMA, M.; FARIAS, M. Diagnostic accuracy of serum assays for mite sensitivity in dogs with atopic dermatitis sensu stricto. Veterinary Dermatology, v. 27, p. 48, 2016.

DEBOER, D.J. Atopic dermatitis – Pathogenesis, clinical signs and diagnosis. North American Veterinary conference, p. 370-371, 2008.

FAVROT, C. et al. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Veterinary Dermatology, v. 21, p. 23-31, 2010.

FLECK, T.J.; BAMMERT, T.J.; SHELLY, J. et al. Identification and characterization of ZTS‐00103289, a monoclonal antibody neutralizing IL‐31‐mediated pruritus in beagle dogs. Veterinary Dermatolology, v. 27, p. 478-e129, 2015.

FISCHER, N.M.; MÜLLER, R.S. Allergen Specific Immunotherapy in Canine Atopic Dermatitis: an Update. Veterinary Dermatology, v. 8, p. 297-302, 2019.

GROSS, T.L.; IHRKE, P.J.; WALDER, E.J.; AFFOLTER, V.K. Perivascular disease of dermis. In: 2005. GROSS TL, IHRKE PJ, WALDER EJ, AFFOLTER VK. Skin diseases of the dog and cat. 2.ed. Oxford:Blackwell Publishing, p. 200-237, 2005.

HARVEY, N.D.; SHAW, S.C.; CRAIGON, P.J.; BLOTT, S.C.; ENGLAND, G.C.W. Environmental risk factors for canine atopic dermatitis: a retrospective large-scale study in Labrador and golden retrievers. Veterinary Dermatology, v. 30, p. 396-e119, 2019.

MARSELLA, R. Approach to the allergic dog. In: Continuing education programme, World Congress of Veterinary Dermatology, Hong Kong. Proceedings of the Continuing Education Programme, p.66-71, 2008.

MARSELLA, R.; OLIVRY, T.; CARLOTTI, D. Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Veterinary Dermatology. v. 22, p. 239-248, 2011.

MICHELS, G.M. et al. A blinded, randomized, placebo-controlled, dose determination trial of lokivetmab (ZTS-00103289), a caninized, anti-canine IL-31 monoclonal antibody in client owner dogs with atopic dermatitis. Veterinary Dermatology, v.27, p.478e-129, 2016.

MOYART, H.; BRUSSEL, L.F.; BOROWKI, S.; ESCALADA, M.; MAHABIR, S.P.; WALTERS, R.R.; STEGEMANN, M.R. A blinded, randomized clinical trial evaluating the efficacy and safety of lokivetmab compared in client-owned dogs with atopic dermatitis. Veterinary Dermatology, v. 28, p. 593-e145, 2017.

NAVARRO, C.; CRASTES, N.; BENIZEAU, E.; MGAHIE, D. Voluntary acceptance and consumption of two oral ciclosporin formulations in dogs: two randomised, controlled studies. Irish Veterinary Journal, v. 68, p. 2-8, 2015.

OLIVRY, T.; MULLER, R.S. Evidence‐based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis. Veterinary Dermatology, v. 14, p. 121-146, 2003.

OLIVRY, T. Pathogenesis of canine atopic dermatites: 2004 hypothesis. Veterinary Dermatology, v. 15 (suppl.), p.1-19, 2004.

OLIVRY, T.; DEBOER, D.J.; FAVROT, C.; JACKSON, H.A.; MULLER, R.S.; NUTALL, T.; PRELAUD, P. Treatment of canine dermatitis: 2010 clinical practice guidlines from the International Task Force on Canine Atopic Dermatitis. Veterinary Dermatology, v. 21, p. 233-248, 2010.

OLIVRY, T. et al. Validation of the canine atopic dermatitis extent and severity index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Veterinary Dermatology, v.25, p. , 2014.

OLIVRY, T.; BRAINBRIDGE, G. Advances in Veterinary Medicine: Therapeutic Monoclonal Antibodies for Companion Animals. Clinical Notes, p.1-4, 2015.

OLIVRY, T.; DEBOER, D.J.; FAVROT, C.; JACKSON, H.A.; MUELLER, R.S.; NUTTALL, T.; PRELAUD, P. Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA). BMC Veterinary Research, v.11, p.210, 2015.

OLIVRY, T.; SARIDOMICHELAKIS, M.N. An update on the treatment of canine atopic dermatitis. The Veterinary Journal, v. 207, p.29-37, 2016.

OLIVRY, T.; BENSIGNOR, E.; FAVROT, C.; GRIFFIN, C.; HILL, P.; MUELLER, R.S.; PLANT, J.D.; WILLIAMS, H.C. Development of a core outcome set for therapeutic clinical trials enrolling dogs with atopic dermatitis (COSCAD’18). BMC Veterinary Research, v.14, p. 238, 2018.

PLUMB, D.C. Glucocorticoid agents, general information. Veterinary drug handbook. Iowa State Press. Ames: Blackwell Publishing, 4 ed., p. 387-389, 2002.

PRELAUD, P.; GUAGUÈRE, E.; ALHAIDARI, Z. et al. Re-evaluation of diagnostic criteria of canine atopic dermatitis. Revue de Médecine Vétérinaire, v. 149, p. 1057-1064, 1998.

POSSEBOM, J.; CUNHA, V.; LIMA, M.; FARIAS, M. Serological identification of low molecular weight allergens from domestics mites associated with canine atopic dermatitis. Veterinary Dermatology, v. 27, p. 49-50, 2016.

REITER, R.L.; TORRES, S.M.; WERTS, P.W. Characterization and quantification of ceramides in the non-lesional skin of canine patients with atopic dermatitis compared with controls. Veterinary Dermatology, v. 20, n. 4, p. 260–266, 2009.

RYBNICEK, J.; LAU-GILLARD, P.J.; HARVEY, R.; HILL, P.B. Further validation of a pruritus severity scale for use in dogs. Journal compilation ESVD and ACVD, v. 20, p. 115-122, 2008.

SOUZA NETO A.; FARIAS, M.R.; PIMPÃO, C.T.; QUITZAN, J.G.; ANATER, A. Eficácia da ciclosporina no controle da dermatite atópica em cães. Pesquisa Veterinária Brasileira, v.37(7), p.729–733, 2017.

SCHINDLER, C.; LEVY, D.E. DECKER, T. JAK‐STAT signaling: from interferons to cytokines. Journal of Biological Chemistry, v. 482, p. 20059-20063, 2007.

SCOTT, D.W.; MILLER, W.H.; GRIFFIN, C.E. Skin immune system and allergic skin diseases. Muller and Kirk's Small Animal Dermatology, 6 ed. Philadelphia, PA: W.B. Saunders Co., P. 432-666, 2001.

WALTERS, R.; BOUCHER, J.P.; PAQUETTE, J.A. et al. Laboratory dose titration efficacy study of ZTS-00103289, a caninized anti-IL-31 monoclonal antibody in a canine model of IL-31-induced pruritus. Veterinary Dermatology, v. 26, p. 145, 2015.

WILLEMSE, T.A. Atopic skin disease: a review and a reconsideration of diagnostic criteria. Journal of Small Animal Practice, v.27, n.11, p.771-778, 1986.

WRIGHT, A.; TATLOCK, S.; WELLS, J. et al. Development of the canine dermatitis quality of life and treatment satisfaction questionnaire: a tool for clinical practice. Proceedings NAVDF (abstract). Veterinary Dermatology, v. 28, p. 453, 2017.

YOUNG, A.J. et al. Canine Pruritus Visual Analog Scale: how does it capture owners’ perception of their pet’s itching level? Veterinary Dermatology, v. 30, p. 377 e-111, 2019.




DOI: https://doi.org/10.34117/bjdv7n6-074

Refbacks

  • There are currently no refbacks.