Single nucleotide polymorphisms in the promoter region of the paraoxonase 1 gene in Bos indicus cows / Polimorfismos de nucleotídeo único na região promotora do gene da paraoxonase 1 em vacas Bos indicus

Natália Ávila de Castro, Pedro Augusto Silva Silveira, Luiz Francisco Machado Pfeifer, Carlos Castilho de Barros, Augusto Schneider


Paraoxonase 1 is an enzyme whose activity serves as a biomarker of uterine health and has been linked to reproductive parameters in cattle, as well as in other species. The aims of the present study were to characterize single nucleotide polymorphisms (SNPs) in the promoter region of the paraoxonase 1 (PON1) gene and to determine the relationship between SNPs and PON1 serum activity in Bos indicus beef cows. Samples from Nelore cows were used for genetic sequencing (n=17) and for genotyping of the SNP-221 and PON1 activity analysis (n=52). Eight SNPs were identified in the promoter region of PON1, from these three SNPs were previously observed in Bos taurus dairy cows. There was no association between any SNP position and PON1 activity. Our results suggest that SNPs in the PON1 promoter does not affect serum PON1 activity in B. indicus beef cows.


Cattle, paraoxonase 1, polymorphism


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