Polimorfismo C677T do gene mthfr na susceptibilidade à hipertensão arterial: evidências baseadas em metanálise / C677T polymorphism of the mthfr gene in susceptibility to arterial hypertension: evidences based on meta-analysis

Authors

  • Raphaela Gomes de Oliveira Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Elisângela Gomes da Silva
  • Lucas Cândido Gonçalves
  • Jacqueline Andréia Bernardes Leão-Cordeiro
  • Fábio Silvestre Ataídes
  • Antonio da Silva Menezes Junior
  • Paulo Alex Neves da Silva
  • Lilian Carla Carneiro
  • Xisto Sena Passos
  • Antonio Márcio Teodoro Cordeiro Silva

DOI:

https://doi.org/10.34117/bjdv.v7i5.29329

Keywords:

Hipertensão, Polimorfismo de Nucleotídeo Único, Biologia Molecular, Metanálise.

Abstract

Introdução: A hipertensão arterial sistêmica (HAS) é uma doença multifatorial, e, dentre os fatores destaca-se a genética, com ênfase ao polimorfismo C677T do gene mthfr, que após codificado, regula o metabolismo da homocisteína, substância danosa aos vasos sanguíneos quando em alta concentração. Objetivo: Avaliar a associação do polimorfismo C677T do gene mthfr e a hipertensão arterial sistêmica. Métodos: Trata-se de revisão sistemática com metanálise, com busca nas bases de dados: PubMed e SciELO, de acordo com os critérios de elegibilidade. Os dados de 20 artigos foram extraídos e os testes estatísticos, considerando limite de significância igual a 5%, foram realizados com o auxílio do software RevMan® 5.4. Resultados: A avaliação genotípica do polimorfismo C677T do gene mthfr apontou relação entre os genótipos TT (mutante) e CT (heterozigoto) com a HAS (respectivamente, OR=1,21; IC95%=1,03-1,43 e OR=1,52; IC95%=1,19-1,95). Na avaliação alélica, a associação ocorreu com o alelo T (OR=1,33; IC95%=1,17-1,53). Os resultados sugerem que o genótipo CC (selvagem) e o alelo C conferem proteção contra a HAS (CC: OR=0,66; IC95%=0,54-0,81 e C: OR=0,82; IC95%=0,74-0,90). Conclusão: Existe associação entre o polimorfismo C677T do gene mthfr e a hipertensão arterial sistêmica. A presença do alelo T em homozigose ou heterozigose aumenta a suscetibilidade genética individual para o desenvolvimento da HAS.

 

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Published

2021-06-07

How to Cite

de Oliveira, R. G., da Silva, E. G., Gonçalves, L. C., Leão-Cordeiro, J. A. B., Ataídes, F. S., Junior, A. da S. M., da Silva, P. A. N., Carneiro, L. C., Passos, X. S., & Silva, A. M. T. C. (2021). Polimorfismo C677T do gene mthfr na susceptibilidade à hipertensão arterial: evidências baseadas em metanálise / C677T polymorphism of the mthfr gene in susceptibility to arterial hypertension: evidences based on meta-analysis. Brazilian Journal of Development, 7(5), 44831–44853. https://doi.org/10.34117/bjdv.v7i5.29329

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Section

Original Papers