Influência da domperidona na reprodução masculina: uma revisão bibliográfica / Influence of domperidone in male reproduction: a bibliographic review

Ewerton Fylipe De Araújo Silva, André Pukey Oliveira Galvão, Adriane Basbosa Fernandes Silva, Bruno Mendes Tenório, Maria Luisa Figueira De Oliveira, Fernanda Das Chagas Angelo Mendes Tenório, Marcelo Moraes Valença

Abstract


Atualmente problemas como a subfertilidade e a infertilidade tem afetado casais em cerca de 50% e 16,7%, respectivamente. Desses, a maior parte está associado à infertilidade masculina, o qual abrange cerca de 8% dos homens. Objetivou-se realizar uma revisão bibliográfica sobre a influência da domperidona na reprodução masculina. Para o estudo buscou-se referenciais relacionados ao tema abordado nas bases de dados do Google Acadêmico, Pubmed, Scielo, Lilacs e Bireme, sendo selecionados trabalhos no período de 1996 a 2020. A domperidona é um medicamento procinético bloqueador da dopamina D2 comumente utilizado para tratar distúrbios da motilidade gastrointestinal. Estudos mostraram que esse medicamento pode causar disfunções na reprodução masculina, pois seu uso causa aumento excessivo nos níveis de prolactina (PRL), observado em 50% dos casos. A PRL modula os receptores FSH e LH nas células de Sértoli e Leydig, e está envolvido na meiose de células germinativas, regulando várias funções dos testículos. O aumento nos níveis de PRL interrompe a secreção pulsátil do hormônio liberador de gonadotrofina, inibe a liberação de LH, FSH, e reduz diretamente a esteroidogênese gonadal, causando efeitos expressivos na espermatogênese, assim como afeitos clínicos como hipogonadismo hipogonadotrófico adquirido e até infertilidade. Diante do exposto, pode-se considerar que a domperidona é um possível indutor a disfunções reprodutivas no homem, devido ao seu potencial de causar desregulação no hormônio que regula as gônadas masculinas.

 


Keywords


Domperidona, Hiperprolactinemia, Testículo, Infertilidade;

References


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DOI: https://doi.org/10.34117/bjdv7n3-028

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