Risk factors associated with increased mortality in septic patients admitted to the intensive care unit/ Fatores de risco associados ao aumento da mortalidade em pacientes sépticos admitidos na unidade de terapia intensiva

Laryssa Renata Muniz Rocha, José Soares do Nascimento, Renata Maria Santos de Freitas, Ariano Brilhante Pegado Suassuna, Hermano Zenaide- Neto

Abstract


Sepsis is a potentially fatal clinical syndrome characterized by an abnormal response to infection associated with organic dysfunction. It is a relevant cause of admission to intensive care units (ICUs) and related to increased morbidity and mortality rates. This study aimed to evaluate the epidemiological profile of adult ICU patients of Lauro Wanderley University Hospital (HULW) in the municipality of João Pessoa (PB) to determine the risk factors associated with increased mortality in patients with sepsis. This retrospective and observational methodological study evaluated the epidemiological profile and characteristics of patients with sepsis, aiming to analyze the risk factors related to increased mortality. The mortality risk analysis was performed in two parts. The first was made from Pearson’s chi-square test to determine the association between categorical variables. Thus, only those variables with p values < 0.05 were included in the final logistic regression model to neutralize the effects of the confounding variables, for which values of p < 0.05 were considered significant. This study’s findings suggest that septic shock and IMV and CVC use are the factors that deserve greater attention in patients with sepsis. However, among them, IMV is the main risk factor for death in ICU patients with sepsis. Variables such as sex, age, and comorbidities did not inflate the death rate for the patients studied.


Keywords


Sepsis, Intensive Care Unit, Epidemiology, Risk Factor.

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References


Aguiar-Ricardo, I.; Mateus, H.; Gonçalves-Pereira J. Hidden mortality in septic patients after discharge from intensive care unit. Rev Bras Ter Intensiva. 2019;31(2):122-8.

López-Medina, DC; Hernao-Pérez, M; Arenas-Andrade, J; Hinestroza-Marín, ED; Jaimes-Barragan, FA; Quiroz-Gomez OI. Epidemiology of septic shock in a prehospital medical care service in five Colombian cities. Rev Bras Ter Intensiva. 2020;32(1):28-36.

Westphal GA, Pereira AB, Fachin SM, Caldara AC, Carolina A, Junqueira G, et al. Characteristics and outcomes of patients with community and hospital acquired sepsis. 2019;31(4):71–8.

Machado FR, Cavalcanti AB, Bozza FA, Ferreira EM, Angotti Carrara FS, Sousa JL, et al. The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study. Lancet Infect Dis [Internet]. 2017;17(11):1180–9. Available at: http://www.sciencedirect.com/science/article/pii/S1473309917303225

Prado RP, Volpáti NV, Raphael F, Gimenes E, Atila E, Maggi E, et al. Risk factors for death in patients with sepsis in an intensive care unit. Revistarene. 2018;19(3231):1–8.

Anselmo Júnior, E; Stella, DKD; Araújo JM; Souza, ES; Schuelter-Trevisol F. Incidence of nosocomial sepsis in adults in an Intensive Care Unit, Tubarão (SC), in 2013. Arq Catarin Med. 2017;46(4):17-26.

Santos AM, Souza GRB OAS. Sepsis in adults in intensive care unit: clinical characteristics. Arq Med Hosp Fac Cienc Med St Casa São Paulo. 2016;61(1):3-7.

Barros LLS, Ferraz S, Monteiro MC. Risk factors associated with aggravation of sepsis in patients in Intensive Care Unit. 2016;24(4):388-96.

Santos AV, Silva AAO, Sousa FAL, Carvalho MM, Carvalho LRB, Moura MEB. Epidemiological profile of sepsis in an emergency hospital. In 1990, the Center of Con. REPIS CENTER. 2015;1(1):19–30.

Luz Filho CA, Marinho CMM, Dôres PS. intensiva: uma revisão integrativa Risk factors in patients with sepsis in intensive care units : An integrative review Factores de riesgo en pacientes con sepsis en unidades de terapia intensiva : Una revisão. Revision Acervo Saúde. 2018;19(208):1-8.

Zonta FNS, Velasquez PGA, Velasquez LG, Demetrio LS, Miranda D, Silva MCBD. Epidemiological and clinical characteristics of sepsis in a public hospital in Paraná. Rev Epidemiol and Control infection of Hosp St. Cruz. 2018;8(3):1-8.

Zanon F, Caovilla JJ, Michel RS, Cabeda EV, Ceretta DF, Luckemeyer GD, et al. Sepsis in the intensive care unit: etiologies, prognostic factors and mortality. Rev Bras Ter Intensiva. 2008;20(2):128-34.

Rosenthal VD, Maki DG, Salomao R, Álvarez-Moreno C, Mehta Y, Higuera F, et al. Device-associated nosocomial infections in 55 intensive care units of 8 developing countries. Ann Intern Med. 2006;145(8):582-91.

DE MOURA PIRES, Henrique Fernandes et al. Sepse em unidade de terapia intensiva em um hospital público: estudo da prevalência, critérios diagnósticos, fatores de risco e mortalidade. Brazilian Journal of Development, v. 6, n. 7, p. 53755-53773, 2020.




DOI: https://doi.org/10.34117/bjdv7n2-435

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