Acupuncture and expression of neurotransmitters in temporomandibular disorders: Systematic review / Acupuntura e expressão de neurotransmissores em desordens temporomandibulares: Revisão sistemática

Maria Cristina Ramos Vilela, Carina Mabel de Albuquerque Ramos, Hilton Justino da Silva, Rhowena Jane Barbosa de Matos


Temporomandibular disorders (TMD) is a common condition of chronic orofacial pain. Acupuncture is a therapeutic method of traditional Chinese medicine (TCM) and some studies to get understand the mechanisms of action and molecular basis involved in this approach therapeutic. We propose to verify in the current literature on the integration of neurotransmitters expression in treat temporomandibular joint disorders by acupuncture in adulthood. A predefined protocol was used and registered on PROSPERO. This qualitative review of the literature analysed international scientific publications in several databases that used the following keywords: Temporomandibular Joint Disorders OR Acupuncture OR Neurotransmitter. Then, in the study selection phase, the eligible texts were read in full to determine their final inclusion or exclusion. The pre-established selection criteria in the protocol determined the inclusion or exclusion of studies during the selection phase. Although to know the diverse effects of acupuncture are intrinsically linked at the cellular and molecular level there is not yet any paper about this in adulthood, but there is a publication about the relationship between TMD and Acupuncture Treatment. There are no studies in the literature that correlate the temporomandibular disorders, acupuncture therapy and neurotransmitters in humans.


Acupuncture, Neurotransmitters, Temporomandibular Disorders.

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