Anti-esquistossomicida triterpeno lupano di-hidroxilado isolado de Struthanthus siringifolius Mart. (Loranthaceae) / Anti-schistosomiasis dihydroxylated lupane triterpenoid ester from Struthanthus syringifolius Mart. (Loranthaceae)

Carla Aparecido Silva Lopes, Leticia Pereira Pimenta, Rita Cássia Nascimento Pedroso, Amanda Lonardi Goes, Cristiane Conceição de Souza, Lucas Antonio de Lima Paula, Lizandra Guidi Magalhães, Valéria Maria Melleiro Gimenez, Milton Groppo, Marcio Luis Andrade e Silva, Wilson Roberto Cunha, Patricia Mendonça Pauletti, Ana Helena Januário

Abstract


Struthanthus siringifolius Mart. (Loranthaceae) é uma espécie do Cerrado brasileiro conhecida como “erva de passarinho”. É popularmente usada para tratar tuberculose e problemas pulmonares. Esta espécie é raramente estudada no Brasil e seu perfil químico e potencial farmacológico são pouco conhecidos. Neste trabalho relatamos o isolamento do triterpeno lupano 7β, 15α-di-hidroxi-lup-20- (29) -eno-3β-O-palmitato (1) do extrato etanólico das partes aéreas de S. siringifolius. Na dose de 200 μM, este triterpeno diidroxilado matou 25 e 50% dos vermes adultos de Schistosoma mansoni em 48 e 72 h, respectivamente. Adicionalmente, nas doses de 25 e 50 μM, esse mesmo triterpeno diminuiu significativamente a atividade motora dos vermes adultos de S. mansoni. Esses resultados sugerem que os triterpenos do tipo lupano podem estar associados à atividade esquistossomicida de S. Syringifolius e devem ser considerados para estudos antiparasitários adicionais.

Keywords


Struthanthus syringifolius, Loranthaceae, Esquistossomíase; Schistosoma mansoni, triterpeno.

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DOI: https://doi.org/10.34117/bjdv7n2-033

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