The polymorphism rs2234767 (-1377 G>A) in the FAS gene may be associated with Plasmodium vivax infection in the Brazilian Amazon / O polimorfismo rs2234767 (-1377 G>A) no gene FAS pode estar associado à infecção por Plasmodium vivax na Amazônia brasileira

José Eduardo Gomes Arruda, Felipe Bonfim Freitas, Gustavo Capatti Cassiano, Ricardo Ishak, Ricardo Luiz Dantas Machado, Marinete Marins Póvoa, Antonio Carlos Rosário Vallinoto

Abstract


The present study investigated the association between fatty acid synthase (FAS) and FAS ligand (FASL) gene polymorphisms in 128 and 99 individuals with and without Plasmodium vivax infection, respectively, in an endemic area of the Brazilian Amazon. Polymorphism genotyping was performed by real-time PCR (qPCR). Analysis of allele and genotype frequency distributions in the FAS-670 (A>G), FASL-844 (C>T) and FASL-124 (A>G) positions did not indicate statistically significant differences between the populations studied here. However, differences in the genotype frequencies of FAS-1377 G>A between the group of individuals infected with P. vivax and the control group were statistically significant (p = 0.007), suggesting an association between this polymorphism and susceptibility to infection.

 

 


Keywords


Malaria, Plasmodium vivax, Polymorphism, Apoptosis.

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DOI: https://doi.org/10.34117/bjdv7n1-515

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