Association between the -420 C> G polymorphism (rs1862513) in the human resistin gene and obesity in a sample of the Brazilian population / Associação entre o polimorfismo -420 C>G (rs1862513) no gene da resistina humana e obesidade em uma amostra da população brasileira

Adaline Franco Rodrigues, Mohara Bruna Franco, Kyrla Cartynalle das Dores Silva Guimarães, Vitor Gabriel Felipe, Wagner Gouvêa dos Santos


Purpose: Obesity became a serious public health problem in the last decades and is associated with several comorbidities such as type 2 diabetes, cardiovascular diseases, and some types of cancer. Adipose tissue cells produce various proinflammatory cytokines including resistin (RETN). Several studies have shown that RETN polymorphisms may be potentially related to the predisposition to obesity, but the results are contradictory. Herein we aimed to investigate the frequency of the RETN -420 C>G (rs1862513) polymorphism and its association with obesity in a sample of adults of both sexes residing in the city of Jataí - GO, Brazil. Subjects and Methods: This cross-sectional study was conducted with 117 participants from which 72 were genotyped for RETN polymorphism. Anthropometric measurements such as body mass index (BMI) and waist circumference (WC) were obtained and used to classify individuals in eutrophic, overweight and obese. Systolic and diastolic blood pressure (SBP and DBP) were measured and lipidic and fasting blood glucose profiles were determined. Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: There was no statistical difference between the RETN -420 C >G polymorphism and the variables BMI and lipidic profile. However, there was a significant difference in the frequency of  C/C genotype in the group with WC values associated with high risk of cardiovascular disease compared to the lower risk group both in the codominant model (C/C; C/G, G/G) and in the dominant genetic model (C/C, C/G + G/G).Conclusion: RETN -420 C >G polymorphism is not associated with obesity in the sample of Brazilian population analyzed in this study, however the RETN C/C genotype may be associated with cardiovascular risk and deserves further investigation.


PCR-RFLP, RETN, Waist Circumference, Metabolic Syndrome, Body Mass Index.

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