Efeitos adversos decorrentes do uso de anti-hipertensivos em pacientes de um ambulatório de atenção primária na cidade de Salvador- Bahia / Adverse effects arising from the use of anti-hypertensive in patients in a primary attention ambulatory in the city of Salvador-Bahia

Melquisedeque do Amparo Santos, Matheus Teles de Sousa, Isabela dos Santos Pereira, Hans Alberto Toledo da Fonseca, Murilo Lopes Pereira, Cláudio Marcelo Bittencourt das Virgens, Josiane Silva Martins Carvalho, Fernando Luís de Queiroz Carvalho

Abstract


A hipertensão arterial sistêmica é uma condição clínica crônica com alta prevalência. O tratamento farmacológico pode causar efeitos adversos (EAs) nos pacientes. O objetivo desse trabalho foi investigar os EAs em hipertensos tratados farmacologicamente. Trata-se de um estudo observacional transversal, descritivo, realizado em um ambulatório em Salvador-Bahia. Dos 57 pacientes, 75,4% (43) eram do sexo feminino e 52,6 % (30) são negros. As médias de idade, Pressão Arterial Sistólica (PAS), Pressão Arterial Diastólica (PAD) e do número de anti-hipertensivos (AHs) foram, respectivamente 63,7 (dp=11,4), 132,1 (dp=16,01), 81,7 (dp=14,1) e 2,2 (dp=0,9). Não houve diferença entre os sexos quanto ao número de EAs (p=0,827) e entre idade e EAs (p=0,999). Houve associação entre o número de EAs e o número de AHs utilizados (p=0,001) e entre a PAS e EAs (p=0,007). Fraqueza foi o EA mais relatado por pacientes que usavam combinação com mais de dois AHs em relação às combinações com menos de dois AHs (p=0,008). O uso de hidroclorotiazida (HCT) e atenolol combinados a outros AHs esteve mais associado à tontura em relação as combinações que incluíam apenas um ou nenhum desses dois fármacos (p=0,010). Nas combinações que continham HCT e anlodipino houve mais relatos de cefaleia (p=0,045), tontura (p=0,004), fraqueza (p=0,001) e náuseas (p=0,045) em comparação com combinações que continham apenas um ou nenhum desses dois AHs. O uso de HCT combinada com outros AHs mostrou associação com os relatos de fraqueza (p=0,041) e tontura (p=0,012), quando comparada às combinações sem esse medicamento.


Keywords


Hipertensão Arterial Sistêmica, Anti-hipertensivos, Efeitos Adversos.

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DOI: https://doi.org/10.34117/bjdv7n1-008

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