Polifenóis dietéticos e função endotelial em adultos sem diagnóstico de doenças: Uma revisão sistemática de ensaios randomizados / Dietary polyphenols and endothelial function in adults without a disease diagnosis: A systematic review of randomized trials

Gabriel Bastos dos Santos Lôbo, Amanda Valente da Silva, Gisele Barreto Lopes Menezes

Abstract


Introdução: Os polifenóis são um grupo de moléculas de origem vegetal. A ingestão dietética desses compostos advém, principalmente, de frutas, leguminosas, cereais e chás. Esses compostos possuem notáveis atividades, em destaque a ação antioxidante que possui atuação no estresse oxidativo (EO) e na patogênese das doenças cardiovasculares (DCV). A disfunção endotelial é gerada, principalmente, pelo EO, e trata-se de uma manifestação precoce de DCV. Objetivo: Revisar e sistematizar ensaios clínicos randomizados que avaliaram os efeitos do consumo de alimentos fontes de polifenóis sobre a função endotelial. Metodologia: foram feitas buscas sistematizadas nas bases de dados MEDLINE, LILACS e SciELO, utilizando MeSH terms. Foram incluídas intervenções em adultos sem diagnósticos clínicos de doenças e sem excesso de peso. Não houve limitações de idiomas ou data de publicação. Resultados: no total 22 estudos foram selecionados e foram agrupados de acordo com as características das intervenções em: cacau e derivados, café, chás, frutas, uva e derivados, oliva e derivados. A dilatação mediada por fluxo (FMD) foi a forma mais frequente de análise da função endotelial, presente em 81,8% das intervenções. Conclusão: a presente revisão demonstrou que os polifenóis presentes nos alimentos analisados, tem potencial de exercer um papel benéfico sobre a função endotelial, entretanto mais estudos de intervenção são necessários para elucidar essa hipótese.


Keywords


Foods, Polyphenols, Vascular endothelium, Endothelial function, Endothelial dysfunction, Clinical trial, Cardiovascular disease.

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DOI: https://doi.org/10.34117/bjdv6n11-085

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