Mecanismos epigenéticos e a ação da expressão da proteína BRCA na carcinogênese mamária / Epigenetic mechanism and the action of BRCA protein expression in mammary carcinogenesis

Gessika Almeida Silva, Nayara Sousa Castro, Ronildo Oliveira Figueiredo

Abstract


Excluindo o câncer de pele não melanoma, o câncer de mama é uma das neoplasias que afetam mulheres do mundo todo. Suas causas estão relacionadas a alterações genéticas e indo por esse campo de pesquisa, vem sendo estudado a relação dos mecanismos epigenéticos com os genes supressores do câncer de mama, BRCA 1 e BRCA2.  O objetivo desta revisão sistemática literária é descrever e correlacionar os mecanismos epigenéticos relacionados aos genes supressores BRCA1 e BRCA2 do carcinoma mamário, além disso, aborda sua posição como método de diagnóstico. Para tanto, as buscas foram feitas nas bases dos periódicos CAPES e foram selecionados artigos de 2005 a 2019. Segundo os achados selecionados, os mecanismos epigenéticos mais relacionado ao câncer de mama são metilação do DNA e os microRNA. Ambos mecanismos, pode defini o tipo de câncer de mama e até em que estágio se encontra através do seu nível de expressão. Devido tais evidencias, esses mecanismos possui uma proposta futurística como método de diagnóstico através de biomarcadores. 


Keywords


Câncer de Mama, BRCA1, BRCA2.

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DOI: https://doi.org/10.34117/bjdv6n10-623

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