Aplicações Terapêuticas da Lepidium meyenii (Maca) e seus compostos químicos: Uma Revisão Sistemática / Therapeutic Applications of Lepidium meyenii (Maca) and its chemical compounds: A Systematic Review

Jobson Josimar Marques Teixeira, Denyse Alves dos Santos, Ana Ferreira da Silva Bezerra, Victória Júlya Alves de Albuquerque, Juliane Cordeiro Vilarins, Valdir Cordeiro de Araújo Júnior, Antonino Borba Ferro, José Edson de Souza Silva


A Lepidium meyenii é uma planta nativa da região dos Andes, bastante utilizada em sua região devido ao alto valor nutricional dela, além de suas propriedades medicinais. Foi realizado uma revisão sistemática, a fim de identificar e analisar sobre a composição química e as atividades terapêuticas da Lepidium meyenii. Detectou-se nos estudos avaliados muitos benefícios dessa planta, alguns já eram esperados como ação antioxidante, antifadiga, anti-inflamatório, mas outras nos surpreenderam como as ações neuroprotetora, imunomoduladora, regulador hormonal entres outros efeitos terapêuticos. Estes fatos mudam a percepção e a importância dessa planta para a humanidade.


Lepidium meyenii, Ação Terapêutica, Composição Química.


AI, Zhong et al. Antidepressant-like behavioral, anatomical, and biochemical effects of petroleum ether extract from maca (Lepidium meyenii) in mice exposed to chronic unpredictable mild stress. Journal of medicinal food, v. 17, n. 5, p. 535-542, 2014.

ALMUKADI, Haifa et al. The macamide N-3-methoxybenzyl-linoleamide is a time-dependent fatty acid amide hydrolase (FAAH) inhibitor. Molecular neurobiology, v. 48, n. 2, p. 333-339, 2013.

ALVAREZ, Evelyn; ALZAMORA-GONZALES, Libertad. Effect of Lepidium meyenii (maca) on the production of three hematopoietic cytokines in splenocytes from immunosuppressed mice. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, p. 313-321, 2013.

AVELAR, Alberto et al. Maca (Lepidium meyenii) supplementation increases the sexual capacity of low but not high sexual performance rams (Ovis aries). Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, v. 15, n. 3, p. 144-150, 2016.

BAI, Naisheng et al. Flavonolignans and other constituents from Lepidium meyenii with activities in anti-inflammation and human cancer cell lines. Journal of agricultural and food chemistry, v. 63, n. 9, p. 2458-2463, 2015.

CAICAI, Kang et al. Isolation, purification and antioxidant activity of polysaccharides from the leaves of maca (Lepidium Meyenii). International journal of biological macromolecules, v. 107, p. 2611-2619, 2018.

CARVALHO, Fernanda V.; RIBEIRO, Paulo R. Structural diversity, biosynthetic aspects, and LC-HRMS data compilation for the identification of bioactive compounds of Lepidium meyenii. Food Research International, v. 125, p. 108615, 2019.

GAO, Xiao-chen et al. Screening of the Active Component Promoting Leydig Cell Proliferation from Lepidium meyenii Using HPLC-ESI-MS/MS Coupled with Multivariate Statistical Analysis. Molecules, v. 24, n. 11, p. 2101, 2019.

GONZALES, C. et al. Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone‐induced prostatic hyperplasia. Andrologia, v. 44, p. 362-369, 2012.

GONZALES‐CASTAÑEDA, Cynthia et al. Photoprotection against the UVB‐induced oxidative stress and epidermal damage in mice using leaves of three different varieties of Lepidium meyenii (maca). International journal of dermatology, v. 50, n. 8, p. 928-938, 2011.

JIN, Wenwen et al. Aerial parts of maca (Lepidium meyenii Walp.) as functional vegetables with gastrointestinal prokinetic efficacy in vivo. Food & function, v. 9, n. 6, p. 3456-3465, 2018.

KITAMURA, Seiya et al. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. PloS one, v. 12, n. 5, 2017.

LEE, Yun-Kyung; CHANG, Yoon Hyuk. Physicochemical and antioxidant properties of methanol extract from Maca (Lepidium meyenii Walp.) leaves and roots. Food Science and Technology, n. AHEAD, 2019.

LI, Jing et al. Anti-fatigue activity of polysaccharide fractions from Lepidium meyenii Walp.(maca). International journal of biological macromolecules, v. 95, p. 1305-1311, 2017.

LI, Shufang et al. Purification, characterization and biological activities of a polysaccharide from Lepidium meyenii leaves. International journal of biological macromolecules, v. 103, p. 1302-1310, 2017.

LI, Yujuan et al. Maca polysaccharides: Extraction optimization, structural features and anti-fatigue activities. International journal of biological macromolecules, v. 115, p. 618-624, 2018.

PINO‐FIGUEROA, Alejandro; NGUYEN, Diane; MAHER, Timothy J. Neuroprotective effects of Lepidium meyenii (Maca). Annals of the New York Academy of Sciences, v. 1199, n. 1, p. 77-85, 2010.

QURESHI, Mahmood et al. Phytochemical and biological assessments on Lepidium meyenii (maca) and Epimidium sagittatum (horny goat weed). Pakistan journal of pharmaceutical sciences, v. 30, n. 1, 2017.

RANILLA, Lena Galvez et al. Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresource technology, v. 101, n. 12, p. 4676-4689, 2010.

REYES, Thais Huarancca et al. Physiological responses of Lepidium meyenii plants to ultraviolet-B radiation challenge. BMC plant biology, v. 19, n. 1, p. 186, 2019.

RODRÍGUEZ-HUAMÁN, Ángel et al. Antioxidant and neuroprotector effect of Lepidium meyenii (maca) methanol leaf extract against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells. Toxicology mechanisms and methods, v. 27, n. 4, p. 279-285, 2017.

RUBIO, Julio et al. Dose–response effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol. Toxicology mechanisms and methods, v. 21, n. 8, p. 628-634, 2011.

SIFUENTES-PENAGOS, Gabriel; LEÓN-VÁSQUEZ, Susan; PAUCAR-MENACHO, Luz María. Estudio de la Maca (Lepidium meyenii Walp.): cultivo andino con propiedades terapéuticas. Scientia Agropecuaria, v. 6, n. 2, p. 131-140, 2015.

STOJANOVSKA, Lily et al. Maca reduces blood pressure and depression, in a pilot study in postmenopausal women. Climacteric, v. 18, n. 1, p. 69-78, 2015.

SUN, Yuqi et al. Composition analysis and antioxidant activity of essential oils, lipids and polysaccharides in different phenotypes of Lepidium meyenii. Journal of Chromatography B, v. 1099, p. 25-33, 2018.

TAFURI, Simona et al. Chemical analysis of Lepidium meyenii (Maca) and its effects on redox status and on reproductive biology in stallions. Molecules, v. 24, n. 10, p. 1981, 2019.

TANG, Weimin et al. Structural characterization and antifatigue effect in vivo of maca (Lepidium meyenii Walp) polysaccharide. Journal of food science, v. 82, n. 3, p. 757-764, 2017.

TANG, Yun et al. Structure analysis and anti-fatigue activity of a polysaccharide from Lepidium meyenii Walp. Natural product research, v. 33, n. 17, p. 2480-2489, 2019.

WU, Liying et al. Physicochemical and functional properties of a protein isolate from maca (Lepidium meyenii) and the secondary structure and immunomodulatory activity of its major protein component. Food & function, v. 10, n. 5, p. 2894-2905, 2019.

WANG, Ting et al. N‐(3‐methoxybenzyl)‐(9Z, 12Z, 15Z)‐octadecatrienamide promotes bone formation via the canonical Wnt/β‐catenin signaling pathway. Phytotherapy Research, v. 33, n. 4, p. 1074-1083, 2019.

ZHENG, Yue et al. Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice. Journal of the Science of Food and Agriculture, v. 99, n. 3, p. 1405-1412, 2019.

ZHOU, Yanyan et al. Integrated Proteomics and Lipidomics Investigation of the Mechanism Underlying the Neuroprotective Effect of N-benzylhexadecanamide. Molecules, v. 23, n. 11, p. 2929, 2018.

WANG, Wei et al. Structure characterization of one polysaccharide from Lepidium meyenii Walp., and its antioxidant activity and protective effect against H2O2-induced injury RAW264.7 cells. International journal of biological macromolecules, v.118, p.816-833, 2018.

ZHA, Zhengqi et al. Isolation, purification, structural characterization and immunostimulatory activity of water-soluble polysaccharides from Lepidium meyenii. Phytochemistry, v. 147, p. 184-193, 2018.

ZHENG, Wei et al. Lepidium meyenii walp exhibits anti-inflammatory activity against ConA-induced acute hepatitis. Mediators of inflammation, v. 2018, 2018.

TENCI, Barbara et al. Effects of a water extract of Lepidium meyenii root in different models of persistent pain in rats. Zeitschrift für Naturforschung C, v. 72, n. 11-12, p. 449-457, 2017.

UCHIYAMA, Fumiaki et al. Lepidium meyenii (Maca) enhances the serum levels of luteinising hormone in female rats. Journal of ethnopharmacology, v. 151, n. 2, p. 897-902, 2014.

VALDIVIA CUYA, M. et al. Effect of Lepidium meyenii (maca) on testicular function of mice with chemically and physically induced subfertility. Andrologia, v. 48, n. 8, p. 927-934, 2016.

WANG, Sunan; ZHU, Fan. Chemical composition and health effects of maca (Lepidium meyenii). Food chemistry, v. 288, p. 422-443, 2019.

WU, Hui et al. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition. Bioorganic & medicinal chemistry, v. 21, n. 17, p. 5188-5197, 2013.

ZHA, Shenghua et al. Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). Carbohydrate polymers, v. 111, p. 584-587, 2014.

ZHANG, Lijun et al. Protective effect of polysaccharide from maca (Lepidium meyenii) on Hep-G2 cells and alcoholic liver oxidative injury in mice. International journal of biological macromolecules, v. 99, p. 63-70, 2017.

ZHANG, Mengmeng et al. Structural characterization of a novel polysaccharide from Lepidium meyenii (Maca) and analysis of its regulatory function in macrophage polarization in vitro. Journal of agricultural and food chemistry, v. 65, n. 6, p. 1146-1157, 2017.

ZHANG, Mengmeng et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Lepidium meyenii. Journal of agricultural and food chemistry, v. 64, n. 9, p. 1921-1931, 2016.

ZHANG, Yongzhong et al. Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats. Indian journal of pharmacology, v. 46, n. 4, p. 416, 2014.

ZHOU, Yanyan et al. Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients. Scientific reports, v. 7, n. 1, p. 1-14, 2017.

ZOU, Ying et al. Protective effects of Lepidium meyenii (Maca) aqueous extract and lycopene on testosterone propionate‐induced prostatic hyperplasia in mice. Phytotherapy Research, v. 31, n. 8, p. 1192-1198, 2017.

DOI: https://doi.org/10.34117/bjdv6n10-131


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