Comparative histology of the human and teleost fish thymus / Histologia Comparativa de timo de humanos e peixes teleósteos
DOI:
https://doi.org/10.34117/bjdv6n9-331Keywords:
Histology, thymus, lymphocytesAbstract
Thymus is considered a key component of the vertebrates’ immune system. It is an organ that is only found in these animals whose development may be accompanied through the evolutionary scale, being considered as a facilitator and regulator in the interaction of lymphoid cells and lymphoid organs. In this study not only a morphological but also functional homology were demonstrated, in that it affects the immune system, of the humans and teleost fish thymus. The material of study was composed of the thymus tissue samples of humans who were donated by the Department of Pathology of Hospital Parmenio Piñero, Buenos Aires Argentina belonging to two patients with ages between 6 and 8 years, as well as specimens of fish from different origins. The thymic tissue samples were submitted to histological analysis, immunohistochemistry and transmission electron microscopy. Through the data shown here it is possible to consider that, both in fish as in humans, there are two tracks in the modulation of the immune response, an afferent pathway that begins with the presentation of the antigen and an efferent pathway through which the result of the lymphocytes, antibodies stimulation or other effector mechanisms are canalized. In these two phases both in humans and in fish, a mixed population of lymphocytes, the differentiation of lymphocytes in the thymus and the T4 lymphocytes production, play a fundamental role in the success of the immune response.
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References
AGHAALLAEI, N. et al. Characterization of mononuclear phagocytic cells in medaka fish transgenic for a cxcr3a:gfp reporter. Proc. Natl. Acad. Sci., v. 107, p. 18079-18084, 2010.
AGIUS, C. The melano-macrophage centres of fish: A review. In: MANNING, M. J.; TATNER, M. F., Fish Immunology, Academic Press, Londres, p. 85-106, 1985.
ANDERSON, D. P. Fish Immunology. T.F.H. Publications, Neptune, NJ, 239p., 1974.
ANDERSON, D. P. Immunological indicators: effects of environmental stress on immune protection and disease outbreaks. Am. Fish. Soc. Syrup., v. 8, p. 38-50, 190.
ARKOOSH, M. R. et al. Suppression of immunological memory in juvenile chinook salmon (Oncorhynchus tshawytscha) from an urban estuary. Fish and Shell?sh Immunology, v. 1, p. 261-277, 1991.
ASHFAQ, H. et al. CD4: a vital player in the teleost fish immune system. Veterinary Research, v. 50, p. 1-11, 2019.
BASSITY, E.; CLARK, T. G. Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss). PLoS ONE, v. 7, p. 33196, 2012.
BATISTA, C. R. et al. Impair- ment of the immune system in GH-overexpressing transgenic zebrafish (Danio rerio). Fish & Shellfish Immunology, v. 36, p. 519-524, 2014.
BATISTA, C. R. et al. Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system. Fish & Shellfish Immunology, v. 45, p. 725-732, 2015.
BOEHM, T.; BLEUL, C. C.; SCHORPP, M. (2003). Genetic dissection of thymus development in mouse and zebrafish. Immunol., v. 195, p. 15-27, 2003.
DIXON, B.; STET, R. J. The relationship between major histocompat? ibility receptors and innate immunity in teleost fish. Dev Comp Immunol., v. 25, p. 683-699, 2001.
FERGUSSON, H. W. Systemic pathology of fish. A text and atlas of comparative tissue responses in diseases of teleosts. Iowa State Univ Press/Ames., p. 64-103, 1989.
GIDEON, G. I.; MACKAY, R. The Human Thymus. 1st Edition eBook, Butterworth-Heinemann Published, 368p., 1969.
HAMXAR, J. A. Zur Kenntnis der Teleostierthymus. Arch. f. mikr. Anat., v. 73, p. 1-68, 1909.
HIROKAWA, K.; UTSUYAMA, M.; KOBAYASHI, S. Hypothalamic control of development and aging of the thymus. Mech Aging Dev., v. 100, p. 177-185, 1998.
HOLLAND, M. C.; LAMBRIS, J. D. The complement system in teleosts. Fish Shellfish Immunol., v. 12, p. 399-420, 2002.
HSU, S. M.; RAINE, L.; FANGER, H. Use of avidin biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparatsion between ABC an unlabeled antibody (PAP) procedures. J Histochem Cytochem., v. 29, p. 577, 1981.
JACOBS, M. T.; FRUSH, D. P.; DONNELLY, L. F. The right place at the wrong time: historical perspective of the relation of the thymus gland and pediatric radiology. Radiology, v. 210, p. 11–16, 1999.
KATO, G. et al. CD4 and CD8 homologues in Japanese flounder, Paralichthys olivaceus: differences in the expressions and localizations of CD4?1, CD4?2, CD8? and CD8?. Dev Comp Immunol., v. 39, p. 293-301, 2013.
KLOSTERHOFF, M. C. et al. Ontogenic development of kidney, thymus and spleen and phenotypic expression of CD3 and CD4 receptors on the lymphocytes of cobia (Rachycentron canadum). Anais da Academia Brasileira de Ciências, v. 87, p. 2111-2121, 2015.
LELE, S. H. On the phasical activity of the thymus gland in plaice of various ages with note on the evolution of the organ, including also notes on the other ductless glands in this species. J. Univ. Bombay, v. 1, p. 37-53, 1932.
LELE, S. M.; LELE, M. S.; ANDERSON, V. M. The thymus in infancy and childhood: embryologic, anatomic, and pathologic considerations. Chest Surg Clin N Am., v. 11, p. 233-253, 2001.
MANLEY, N. R. Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation. Semin Immunol., v. 12, p. 421-428, 2000.
MAY, M. T. Galen on the usefulness of the parts of the body. Ithaca, NY: Cornell University Press, 30p., 1968.
MILLER, J. F. Immunological function of the thymus. Lancet, v. 2, p. 748-9, 1961.
MOKHTAR, D. M. Fish Histology. From Cells to Organs. Apple Academic Press Inc. 3333, Mistwell Crescent Oakville, ON L6L 0A2 Canada, p. 102-103, 246p., 2017.
MOORE, K. L.; PERSAUD, T. V. N. The branchial or pharyn-geal apparatus. In: MOORE, K. L.; PERSAUD, T. V. N. (Eds.), The developing human. Clinically oriented embryology. 5th ed., Philadelphia, PA: WB Saunders, p. 193-200, 1993.
NISHINO, M. et al. The thymus: a comprehensive review. Radiographics, v. 26, p. 335-48, 2006.
OWEN, J. J. et al. The role of mesenchyme in thymus development. Curr Top Microbiol Immunol., v. 251, p. 133-7, 2000.
RASMUSSEN, A. S.; ARNASON, U. Molecular studies suggest that cartilaginous fishes have a terminal position in the piscine tree. Proc. Nat. Acad. Sci., v. 96, p. 2177-2182, 1999.
RIO-HORTEGA, P. del. El método del carbonato argéntico. Revisión general de sus técnicas y aplicación en histología normal y patológica. Ann. Histol. Norm. Patol., v. 1, p. 165-205, 1942.
ROBERTS, R. J. The immunology of teleost. In: Fish Pathology, (4th Edition, 590p), Wiley-Blackwell, London, p. 144-166, 2012.
RODEWALD, H. R. Thymus organogenesis. Annu Rev Immunol., v. 26, p. 355-88, 2008.
ROITT, I.; BROSTOFF, M. A.; MALE, J. Immunology. Mosby, 6th edition, 496p., 2001.
ROMANO, L. A.; MAROZZI, V.; ZENOBI, C. Utilizacion de anticuerpos humanos en la marcación de receptores CD3 y CD4 de linfocitos en Xiphophorus hellerii. Rev Soc Científica Argent., v. 43, p. 123-127, 2004.
ROMANO, L. A. El sistema Imune de los Peces. In: SILVA-SOUZA, A.T.; PEREZ LIZAMA, M.A.; TAKEMOTO, R.M. (Eds.), Patologia e Sanidade de Organismos Aquáticos. Abrapoa, 550p., 2010.
SKINNER, H. A. Origin of medical terms. 2nd ed., Bal- timore, Williams & Wilkins Company, 404p., 1961.
STANNIUS, H. Ueber eine der Thymus entsprechende Drüse bci Knochcn- fischen. Muller ’s Arch., p. 501-507, 1850.
URIBE, C. et al. Innate and adaptive immunity in teleost fish: A review. Vet. Med., v. 56, p. 486-503, 2011.
ZAPATA, A. G.; CHIBA, A.; VARAS, A. Cells and tissues of the immune system of fish. In: IWAMA, G.; NAKANISHI, T. (Eds.), The fish immune system: organism, pathogen, and environment, San Diego: Academic Press, 162p., 1996.
ZHU, L. Y. et al. Advances in research of fish immune-relevant genes: A comparative overview of innate and adaptive immunity in teleosts. Dev. Comp. Immunol., v. 39, p. 39-62, 2013.
