Antiproliferative and anti-inflammatory activity from aerial parts of Psychotria cupularis (Rubiaceae) / Atividade antiproliferativa e anti-inflamatória das partes aéreas de Psychotria cupularis (Rubiaceae)

Matheus A. Peixoto, José G. S. Corrêa, Vagner M. de Moura, Juliana F. da Silva, Franciele Q. Ames, Armando M. Pomini, João E. de Carvalho, Ana Lúcia T. G. Ruiz, André M. A. Amorim, Ciomar A. Bersani-Amado, Silvana M. O. Santin

Abstract


The crude extract and fractions of aerial parts from Psychotria cupularis, collected at Camacan (Brazil), were tested for anti-inflammatory and antiproliferative activity. A phytochemical screening indicated the presence of tannins, anthraquinones, triterpenes, steroids and flavonoids. The crude extract and fractions inhibited the ear oedema in mice between 50.2 to 87.2% and the myeloperoxidase enzyme activity between 51.6 to 97.1%. The butanolic and ethyl acetate fractions was active against glioma, breast, ovary, kidney, colon and leukaemia cell line (IG50 = 4.3 to 16.9 μg/mL).

 

 


Keywords


Psychotria cupularis, Rubiaceae, anti-inflammatory activity, antiproliferative activity, phytochemical screening, pharmacology.

Full Text:

PDF

References


Almeida P.D.O., Boleti A.P.A., Rüdiger A.L., Lourenço G.A., Veiga Júnior V.F., Lima E.S., 2015. Anti-inflammatory activity of triterpenes isolated from Protium paniculatum Oil-Resins. Evidence-Based Comp. Alt. Med. 10 pages.

Aquino P., Figueredo F.G., Pereira N., Nascimento E., Martin A., Veras H., Oliveira C., Ferreira S., Leandro L., Silva M., Menezes I., 2016. Evaluation of the topical anti-inflammatory activity and antibacterial activity of methanol extract in the Sideroxylon obtusifolium Leaves. Acta Biol. Colomb. 21, 131-140.

Bradley P.P., Priebat D.A., Christensen R.D., Rothstein G., 1982. Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker. J. Invest. Dermatol. 78, 206–209.

Calixto N.O., Pinto M.E.F., Ramalho S.D., Burger M.C.M., Bobey A.F., Young M.C.M., Bolzani V.S., Pinto A.C., 2016. The Genus Psychotria: Phytochemistry, chemotaxonomy, ethnopharmacology and biological properties. J. Braz. Chem. Soc. 27, 1355-1378.

Cragg G.M., Newman D.J., Yang S.S., 2006. Natural products extracts of plan and marine origin having antileukemia potential. The NCI experience. J. Nat. Prod. 69, 488-498.

Dai Y., Harinantenaina L., Brodie P.J., Birkinshaw C., Randrianaivo R., Applequist W., Ratsimbason M., Rasamison V.E., Shen Y., TenDyke K., Kingston D.G.I., 2013. Two antiproliferative triterpene saponins from Nematostylis anthophylla from the highlands of central Madagascar. Chem. & Biodiv. 10, 233-240.

De Moura, V. M.; Ames, F. Q.; Corrêa, J. G. S.; Peixoto, M. A.; Amorim, A. M. A.; Pomini, A. M.; De Carvalho, J. E.; Ruiz, A. L. T. G.; Bersani-Amado, C. A.; Santin, S. M. O. Cytotoxicity and anti-inflammatory effects of the extract, fractions and alkaloids from Palicourea minutiflora (Rubiaceae). Nat. Prod. Res., v. 11, p. 1-5, 2020.

Dholwani K.K., Saluja A.K., Gupta A.R., Shah D.R., 2008. A review on plant-derived natural products and their analogs with antitumor activity. Indian J. Pharmacol. 40, 49-58.

Farias F.M., Passos C.S., Arboc M.D., Barros D.M., Gottfriede C., Steffen V.M., Henriques A.T., 2012. Strictosidinic acid, isolated from Psychotria myriantha Mull. Arg. (Rubiaceae), decreases serotonin levels in rat hippocampus. Fitoterapia. 83, 1138-1143.

Hayashi T., Smith F.T., Lee K.H., 1987. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships. J. Med. Chem. 30, 2005-2008.

Huang J., Wang Y., Li C., Wang X., He X., 2016. Anti-inflammatory oleanolic triterpenes from chinese acorns. Molecules. 21, 669-677.

Iniyavan M., Sangeetha D., Saravanan S., Parimelazhagan T., 2012. Evaluation of antioxidant and pharmacological properties of Psychotria nilgiriensis Deb & Gang. Food Sci. Biotechnol. 21, 1421-1431.

Kashiwada Y., Nonaka G., Nishioka I., Chang J.J., Lee K.H., 1992. Tannins and related compounds as selective cytotoxic agents. J. Nat. Prod. 55, 1033-1043.

Liu J., Ding Y., Zhang Y., Chen J., Cui B., Bai J., Lin M., Hou Q., Zhang P., Li S., 2015. Anti-inflammatory hydrolyzable tannins from Myricaria bracteata. J. Nat. Prod. 78,1015−1025.

Liu J., 1995. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharm. 49, 57-68.

Mariyammal R., Kavimani S., 2013. Anti-Inflammatory activity of methanol extract of the whole plant of Psychotria octosulcata. W. A. Talbot. Int. J. Pharm. Res. Rev. 2,1-5

Marques T.S., Pereira D.T.M., Abreu A.S., Souza M.A.S., 2016. Determinação do perfil fitoquímico e avaliação das atividades biológicas de extrato da espécie Scleronema micranthum da família Bombacaceae. Rev. Fitos. 10, 375-547. Brazilian portuguese.

Matos F.J.A. 2009. Introdução à fitoquímica experimental. 3ª ed. UFC, 150p. Brazilian portuguese.

Medina R.P., Moura V.M., Silva C.C., Oliveira C.M.A., Kato L., Pomini A.M., Carvalho J.E., Ruiz A.L.T.G., Bersani-Amado C.A., Santin SMO., 2018. Anti-inflammatory and antiproliferative activities of Ixora brevifolia Benth. (Rubiaceae). Nat. Prod. Res. 32, 1357-1360.

Moghaddam G., Ebrahimi S.A., Rahbar-Roshandel N., Foroumadi A., 2012. Antiproliferative activity of flavonoids: influence of the sequential methoxilation state of the flavonoid structure. Phytother. Res. 26, 1023-1028.

Monks A., Scudiero D., Skehan P., Shoemaker R., Paull K., Vistica D., Hose C., Langley J., Cronise P., Vaigro-Wolff A., 1991. Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines. J. Nat. Cancer. Inst. 83, 757–766.

Moraes T.M.S., Araújo M.H., Bernardes N.R., Oliveira D.B., Lasunskaia E.B., Muzitano M.F., Cunha M., 2011. Antimycobacterial activity and alkaloid prospection of Psychotria species (Rubiaceae) from the brazilian atlantic rainforest. Planta Med. 77, 964-970.

Mota M.L.R., Thomas G., Barbosa J.M., 1985. Anti-inflammatory actions of tannins isolated from the bark of Anacardium occidentale. J. Ethnopharm. 13, 289-300.

Porto D.D., Henriques A.T., Fett-Neto A.G., 2009. Bioactive Alkaloids from South American Psychotria and Related Species. The Open Bioact. Comp. J. 2, 29-36.

Queiroz G.S., Luz A.B.G., Nascimento M.V.P.S., Thomasi S.S., Ferreira A.G., Dalmarco E.M., Brighente I.M.C., 2017. Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae). J. Appl. Pharmac. Sci. 7, 168-173.

Romero-Estrada A., Maldonado-Magaña A., González-Christen J., Bahena S.M., Garduño-Ramírez M.L., Rodríguez-López V., Alvarez L., 2016. Anti-inflammatory and antioxidative effects of six pentacyclic triterpenes isolated from the Mexican copal resin of Bursera copallifera. BMC Complem. Alt. Med. 16, 422-431.

Santos K.P., Motta L.B., Santo D.Y.A.C., Salatino M.L.F., Salatino A., Ferreira M.J.P., Lago J.H.G., Ruiz A.L.T.G., Carvalho J.E., Furlan C.M., 2015. Antiproliferative activity of flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae). BioMed. Res. Int. 7 pages.

Topçu G., Yapar G., Türkmen Z., Gören A.C., Öksüs S., Schilling J.K., Kingston D.G.I., 2011. Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh. Phytochem. Lett. 4, 421-425.

Tran P.H., Le V.D., Do T.H., Nguyen T.L., Nguyen P.T., Nguyen T.T., Nguyen T.D., 2017. Anti-inflammatory constituents from Psychotria prainii H. Lév. Nat. Prod. Res. 6, 1-6.

Van Arman, C.G., 1974. Anti-inflammatory drugs. Clin. Pharmacol. Ther. 16, 900-904.

Zhang W., Men X., Lei P., 2014. Review on anti-tumor effect of triterpene acid compounds. J. Cancer Res. Ther. 10, 14-19.




DOI: https://doi.org/10.34117/bjdv6n9-234

Refbacks

  • There are currently no refbacks.