Comparação entre a dose e a distribuição de pontos de aplicação de toxina botulínica tipo A na eficácia para o tratamento de rítides glabelares. Ensaio clínico randomizado duplo cego / Comparison between dose and distribution of botulinum toxin type A application points in efficacy for the treatment of glabellar rhytids. Double blind randomized clinical trial

Authors

  • Eduardo Benassi dos Santos Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Willian Ortega Souza
  • Camila Alexandra Martins Dias
  • Wagner Baseggio
  • Fabiana Scarparo Naufel

DOI:

https://doi.org/10.34117/bjdv6n7-232

Keywords:

Toxinas botulínicas tipo A, Neurotoxinas, Formas de dosagem.

Abstract

A toxina botulínica tem sido empregada de forma segura e eficaz para o tratamento das rítides glabelares. Entretanto, a prática clínica tem sido variada, permanecendo dúvidas sobre a dose ótima desejável bem como a quantidade de pontos de aplicação. O objetivo desse trabalho é, portanto, avaliar o efeito da concentração e dos pontos de aplicação da toxina botulínica na região glabelar sobre a diminuição das linhas de expressão. Quarenta voluntários foram randomicamente divididos em 4 grupos, a saber : G1: injetado um ponto de aplicação no músculo prócero com 5U e um ponto de aplicação em cada músculo corrugador com 5U por ponto; G2: um ponto de aplicação no prócero com 5U e dois pontos de aplicação em cada músculo corrugador com 2,5U em cada ponto; G3: injetado um ponto de aplicação no músculo prócero com 7U e um ponto de aplicação em cada músculo corrugador com 7U por ponto; G4: um ponto de aplicação no prócero com 7U e dois pontos de aplicação em cada músculo corrugador com 5U em cada ponto. Os participantes foram avaliados nos tempos baseline e nas semanas 2, 8, 16 pelo método Facial Wrinkle Scale. Os resultados desse estudo sugerem que entre as dosagens estudadas, 21 U aplicadas em um ponto por músculo é a dose mais efetiva para o tratamento da região glabelar, com durabilidade de 4 meses.

 

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Published

2020-07-10

How to Cite

dos Santos, E. B., Souza, W. O., Dias, C. A. M., Baseggio, W., & Naufel, F. S. (2020). Comparação entre a dose e a distribuição de pontos de aplicação de toxina botulínica tipo A na eficácia para o tratamento de rítides glabelares. Ensaio clínico randomizado duplo cego / Comparison between dose and distribution of botulinum toxin type A application points in efficacy for the treatment of glabellar rhytids. Double blind randomized clinical trial. Brazilian Journal of Development, 6(7), 45329–45340. https://doi.org/10.34117/bjdv6n7-232

Issue

Section

Original Papers