Comparação entre a dose e a distribuição de pontos de aplicação de toxina botulínica tipo A na eficácia para o tratamento de rítides glabelares. Ensaio clínico randomizado duplo cego / Comparison between dose and distribution of botulinum toxin type A application points in efficacy for the treatment of glabellar rhytids. Double blind randomized clinical trial

Eduardo Benassi dos Santos, Willian Ortega Souza, Camila Alexandra Martins Dias, Wagner Baseggio, Fabiana Scarparo Naufel

Abstract


A toxina botulínica tem sido empregada de forma segura e eficaz para o tratamento das rítides glabelares. Entretanto, a prática clínica tem sido variada, permanecendo dúvidas sobre a dose ótima desejável bem como a quantidade de pontos de aplicação. O objetivo desse trabalho é, portanto, avaliar o efeito da concentração e dos pontos de aplicação da toxina botulínica na região glabelar sobre a diminuição das linhas de expressão. Quarenta voluntários foram randomicamente divididos em 4 grupos, a saber : G1: injetado um ponto de aplicação no músculo prócero com 5U e um ponto de aplicação em cada músculo corrugador com 5U por ponto; G2: um ponto de aplicação no prócero com 5U e dois pontos de aplicação em cada músculo corrugador com 2,5U em cada ponto; G3: injetado um ponto de aplicação no músculo prócero com 7U e um ponto de aplicação em cada músculo corrugador com 7U por ponto; G4: um ponto de aplicação no prócero com 7U e dois pontos de aplicação em cada músculo corrugador com 5U em cada ponto. Os participantes foram avaliados nos tempos baseline e nas semanas 2, 8, 16 pelo método Facial Wrinkle Scale. Os resultados desse estudo sugerem que entre as dosagens estudadas, 21 U aplicadas em um ponto por músculo é a dose mais efetiva para o tratamento da região glabelar, com durabilidade de 4 meses.

 


Keywords


Toxinas botulínicas tipo A, Neurotoxinas, Formas de dosagem.

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DOI: https://doi.org/10.34117/bjdv6n7-232

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