Propriedades terapêuticas do gênero cleome, familia cleomaceae / Therapeutic properties of the cleome gender, cleomaceae family

Authors

  • Pármenas Edson de Medeiros Soares
  • João Eduardo Souza Silva
  • José Israel Guerra Junior
  • Gabriela Cavalcante da Silva

DOI:

https://doi.org/10.34117/bjdv6n7-041

Keywords:

Fitoterapia, Compostos Fitoquímicos, Cleome.

Abstract

Contendo mais de 200 espécies de plantas, o gênero Cleome (Cleomaceae) demonstra ser uma vasta fonte de ervas com propriedades medicinais. Dentre as atividades terapêuticas encontradas no gênero está o efeito hepatoprotetor, anti-inflamatório, em neoplasias e infecções. A Cleome spinosa é uma planta pertencente ao gênero Cleome e que pode ser encontrada no Brasil. Extratos da planta foram testados para diversos problemas de saúde como é o caso das infecções, neoplasias e lesões hepáticas. O objetivo desta pesquisa foi o de realizar um levantamento na literatura sobre as propriedades terapêuticas do gênero Cleome com ênfase na Cleome spinosa. O presente estudo, trata-se de uma revisão literária, que se utilizou de 36 artigos, publicados nas bases de dados SciELO, Biblioteca Virtual em Saúde, MEDLINE e LILACS, com recorte temporal entre os anos 2003 até 2020. Foram descritas predominantemente as propriedades terapêuticas das plantas, dados dos ensaios e em menor proporção os aspectos etnofarmacológicos e botânicos. Em sumo, o gênero Cleome, detém de uma vasta variedade de constituintes químicos em sua composição, que por sua vez detém de diversas atividades biológicas, que podem servir como base para desenvolvimento de novos produtos para a terapêutica, entretanto se faz necessários mais estudo para elucidação dos mecanismos de ação e da atividade toxicológica.

References

AMADI, P.u. et al. Toxicities of selected medicinal plants and floras of lower phyla. Alexandria Journal Of Medicine, [s.l.], v. 54, n. 4, p.587-596, dez. 2018. Informa UK Limited. http://dx.doi.org/10.1016/j.ajme.2018.05.001.

ANDRADE, Fabio D. et al. Ação anti-helmíntica do extrato hidroalcóolico da raiz da Tarenaya spinosa (Jacq.) Raf. no controle de Haemonchus contortus em ovinos. Pesquisa Veterinária Brasileira, [s.l.], v. 34, n. 10, p.942-946, out. 2014. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/s0100-736x2014001000003.

APARADH, Vishal T.; MAHAMUNI, Rahul J.; KARADGE, B. A.. TAXONOMY AND PHYSIOLOGICAL STUDIES IN SPIDER FLOWER (CLEOME SPECIES): A CRITICAL REVIEW. Plant Sciences Feed, Kolhapur, v. 2, n. 3, p. 25-46, abr. 2012.

ARIAS, Daniela M. Robles et al. Non-random medicinal plants selection in the Kichwa community of the Ecuadorian Amazon. Journal Of Ethnopharmacology, [s.l.], v. 246, p.1-8, jan. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.jep.2019.112220.

BERGH, Erik van Den; HOFBERGER, Johannes A.; SCHRANZ, M. Eric. Flower power and the mustard bomb: Comparative analysis of gene and genome duplications in glucosinolate biosynthetic pathway evolution in Cleomaceae and Brassicaceae. American Journal Of Botany, [s.l.], v. 103, n. 7, p.1212-1222, 16 jun. 2016. Wiley. http://dx.doi.org/10.3732/ajb.1500445.

BOSE, Utpal et al. Antinociceptive, cytotoxic and antibacterial activities of Cleome viscosa leaves. Revista Brasileira de Farmacognosia, [s.l.], v. 21, n. 1, p. 165-169, fev. 2011. Springer Science and Business Media LLC. http://dx.doi.org/10.1590/s0102-695x2011005000023.

CARNEIRO, José Arthur Arcanjo et al. Flora do Ceará, Brasil: Cleomaceae. Rodriguésia, [s.l.], v. 69, n. 4, p.1659-1672, dez. 2018. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/2175-7860201869413.

CASTRO, Tatiana Carvalho de et al. Morphological aspects of fruits, seeds, seedlings and in vivo and in vitro germination of species of the genus Cleome. Journal Of Seed Science, [s.l.], v. 36, n. 3, p.326-335, set. 2014. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/2317-1545v36n31013.

CRAGG, Gordon M.; NEWMAN, David J.. Natural products: A continuing source of novel drug leads. Biochimica Et Biophysica Acta (bba) - General Subjects, [s.l.], v. 1830, n. 6, p.3670-3695, jun. 2013. Elsevier BV. http://dx.doi.org/10.1016/j.bbagen.2013.02.008.

Devi BP, Boominathan R, Mandal SC (2003): Evaluation of antipyretic potential of Cleome viscosa Linn. (Capparidaceae) extract in rats. J Ethnopharmacol 87: 11–13.

EZZAT, Shahira M. et al. Antihyperglycemic and antihyperlipidemic effects of the methanol extracts of Cleome ramosissima Parl., Barleria bispinosa (Forssk.) Vahl. and Tribulus macropterus Boiss. Bulletin Of Faculty Of Pharmacy, Cairo University, [s.l.], v. 52, n. 1, p. 1-7, jun. 2014. Egypts Presidential Specialized Council for Education and Scientific Research. http://dx.doi.org/10.1016/j.bfopcu.2013.12.002.

GAHAN, P. B. et al. Life: the science of biology (7th edn) w. k. purves, d. sadava, g. h. orians and h. c. heller, w. h. freeman & co, 1121 pp., isbn 0-7167-9856-5 (2004). : the science of biology (7th edn) W. K. Purves, D. Sadava, G. H. Orians and H. C. Heller, W. H. Freeman & Co, 1121 pp., ISBN 0-7167-9856-5 (2004). Cell Biochemistry And Function, [s.l.], v. 23, n. 3, p. 221-221, 2005. Wiley. http://dx.doi.org/10.1002/cbf.1179

GAO, Shanshan et al. Effects of drought stress on growth, physiology and secondary metabolites of Two Adonis species in Northeast China. Scientia Horticulturae, [s.l.], v. 259, p.1-10, jan. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.scienta.2019.108795.

GEORGE, Philomena. Concerns regarding the safety and toxicity of medicinal plants: Uma visão geral. Journal Of Applied Pharmaceutical Science. Coimbatore, p. 40-44. 3 jul. 2011.

HELAL, Eman G.e. et al. Hypoglycemic and Antioxidant Effects of Cleome Droserifolia (Samwah) in Alloxan-Induced Diabetic Rats. The Egyptian Journal Of Hospital Medicine, [s.l.], v. 58, p. 39-47, jan. 2015. Egypts Presidential Specialized Council for Education and Scientific Research. http://dx.doi.org/10.12816/0009359.

IMANIRAMPA, Lawrence; ALELE, Paul E.. Antifungal activity of Cleome gynandra L. aerial parts for topical treatment of Tinea capitis: an in vitro evaluation. : an in vitro evaluation. Bmc Complementary And Alternative Medicine, [s.l.], v. 16, n. 1, p. 1-8, 8 jul. 2016. Springer Science and Business Media LLC. http://dx.doi.org/10.1186/s12906-016-1187-9.

JALILI-NIK, Mohammad et al. Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells. Drug Research, [s.l.], p.1-6, 9 set. 2019. Georg Thieme Verlag KG. http://dx.doi.org/10.1055/a-0986-6543.

JARADAT, Nidal Amin et al. Carlina curetum plant phytoconstituents, enzymes inhibitory and cytotoxic activity on cervical epithelial carcinoma and colon cancer cell lines. European Journal Of Integrative Medicine, [s.l.], v. 30, p.1-9, set. 2019. Elsevier BV. http://dx.doi.org/10.1016/j.eujim.2019.100933.

KHARCHOUFA, Loubna et al. Profile on medicinal plants used by the people of North Eastern Morocco: Toxicity concerns. Toxicon, [s.l.], v. 154, p.90-113, nov. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.toxicon.2018.09.003.

LEAL et al. Perfil etnobotânico e Atividade Antioxidante de Cleome spinosa (Brassicacea) e Pavonia varians (Malvaceae). Revista Fitos, Natal, v. 3, n. 3, p. 25-31, set. 2007.

MA?AJOWICZ, Jolanta; KU?MIREK, Sabina. Struktura i w?a?ciwo?ci biologiczne rycyny – toksycznego bia?ka r?cznika pospolitego. Post?py Biochemii, [s.l.], v. 65, n. 2, p.103-108, 6 jun. 2019. Polskie Towarzystwo Biochemiczne (Polish Biochemical Society). http://dx.doi.org/10.18388/pb.2019_249.

MALI, Ravindra G.. Cleome viscosa (wild mustard): A review on ethnobotany, phytochemistry, and pharmacology. Pharmaceutical Biology, [s.l.], v. 48, n. 1, p.105-112, 29 dez. 2009. Informa UK Limited. http://dx.doi.org/10.3109/13880200903114209.

MCNEIL, Megil J. et al. Chemical Composition and Antimicrobial Activity of the Essential Oils from Cleome Spinosa. Natural Product Communications, [s.l.], v. 5, n. 8, p.1-6, ago. 2010. SAGE Publications. http://dx.doi.org/10.1177/1934578x1000500833.

MCNEIL, Megil J. et al. Chemical composition and biological activities of the essential oil from Cleome rutidosperma DC. Fitoterapia, [s.l.], v. 129, p. 191-197, set. 2018. Elsevier BV. http://dx.doi.org/10.1016/j.fitote.2018.07.006.

MUHAIDAT, Riyadh et al. Phytochemical investigation and in vitro antibacterial activity of essential oils from Cleome droserifolia (Forssk.) Delile and C. trinervia Fresen. (Cleomaceae). South African Journal Of Botany, [s.l.], v. 99, p. 21-28, jul. 2015. Elsevier BV. http://dx.doi.org/10.1016/j.sajb.2015.03.184.

OGUNMOYOLE, Temidayo et al. Multiple organ toxicity of Datura stramonium seed extracts. Toxicology Reports, [s.l.], v. 6, p.983-989, 2019. Elsevier BV. http://dx.doi.org/10.1016/j.toxrep.2019.09.011.

PEREIRA, Douglas de Almeida; BRITO, Ana Carla; AMARAL, Cláudio Lúcio Fernandes. Biologia fl oral e mecanismos reprodutivos do Mussambê (Cleome spinosa Jacq) com vistas ao melhoramento genético. Revista Biotemas, Jequié-ba, v. 4, n. 20, p. 27-34, dez. 2007. Trimestral.

RODRIGUES, Felicidade Caroline et al. Chemical composition and anti-Candida potencial of the extracts of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae). Comparative Immunology, Microbiology And Infectious Diseases, [s.l.], v. 64, p.14-19, jun. 2019. Elsevier BV. http://dx.doi.org/10.1016/j.cimid.2019.02.005.

SANTOS, F.m. et al. Chemical composition and antimicrobial activity of the essential oil from the leaves and flowers of Aloysia gratissima. Revista Brasileira de Plantas Medicinais, [s.l.], v. 15, n. 4, p.583-588, 2013. FapUNIFESP (SciELO). http://dx.doi.org/10.1590/s1516-05722013000400015.

SILVA, Ana P. Sant'anna da et al. Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc. Frontiers In Microbiology, [s.l.], v. 7, p.1-10, 28 jun. 2016. Frontiers Media SA. http://dx.doi.org/10.3389/fmicb.2016.00963.

SINGH, Harpreet et al. The chemistry and pharmacology of Cleome genus: A review. Biomedicine & Pharmacotherapy, [s.l.], v. 101, p.37-48, maio 2018. Elsevier BV. http://dx.doi.org/10.1016/j.biopha.2018.02.053.

SÜNTAR, Ipek et al. Healing effects of Cornus mas L. in experimentally induced ulcerative colitis in rats: From ethnobotany to pharmacology. Journal Of Ethnopharmacology, [s.l.], v. 248, p.1-36, fev. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.jep.2019.112322.

TAMBOLI, Asif Shabodin et al. Phylogenetic analysis, genetic diversity and relationships between the recently segregated species of Corynandra and Cleoserrata from the genus Cleome using DNA barcoding and molecular markers. Comptes Rendus Biologies, [s.l.], v. 339, n. 3-4, p. 123-132, mar. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.crvi.2016.02.005.

TIGRINE, Chafia et al. Cleome arabicaleaf extract has anticancer properties in human cancer cells. Pharmaceutical Biology, [s.l.], v. 51, n. 12, p. 1508-1514, 18 jul. 2013. Informa UK Limited. http://dx.doi.org/10.3109/13880209.2013.796563.

UZILDAY, B. et al. Comparison of ROS formation and antioxidant enzymes in Cleome gynandra (C4) and Cleome spinosa (C3) under drought stress. Plant Science, [s.l.], v. 182, p. 59-70, jan. 2012. Elsevier BV. http://dx.doi.org/10.1016/j.plantsci.2011.03.015.

YOUNESS, R. et al. Halting triple-negative breast cancer progression through repressing NO machinery by a novel methoxylated flavonol glycoside isolated from Cleome droserifolia. European Journal Of Cancer, [s.l.], v. 92, p. 1-1, abr. 2018. Elsevier BV. http://dx.doi.org/10.1016/s0959-8049(18)30616-6.

ZAPATA, Thirza Ruiz. Cleome L. (Capparaceae) no estado de Aragua, Venezuela. Acta Botánica Venezuélica, [s.l.], v. 29, n. 2, p. 315-334, 2006.

Published

2020-07-02

How to Cite

Soares, P. E. de M., Silva, J. E. S., Guerra Junior, J. I., & Silva, G. C. da. (2020). Propriedades terapêuticas do gênero cleome, familia cleomaceae / Therapeutic properties of the cleome gender, cleomaceae family. Brazilian Journal of Development, 6(7), 42708–42718. https://doi.org/10.34117/bjdv6n7-041

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Section

Original Papers