Atividade larvicida de fungos endofíticos: uma revisão / Larvicidal activity of endophytic fungi: a review

Jakeline Bezerra Pinheiro, Julio Cesar Polonio, Ravely Casarotti Orlandelli, João Alencar Pamphile, Halison Correia Golias

Abstract


O controle de mosquitos vetores de doenças como Dengue, Febre Amarela, Zika, Chikungunya, Malária e Filariose é de extrema importância médica, econômica e social, pois estes ocasionam milhares de mortes anuais e sérios problemas em saúde pública. Os fungos endofíticos são fontes de metabólitos secundários com promissora atividade para o controle das larvas de tais mosquitos, seja a partir de extratos brutos ou da síntese de nanopartículas metálicas. Essa revisão buscou identificar os trabalhos envolvendo os fungos endofíticos com potencial larvicida contra as espécies de mosquitos Anopheles sp., Culex sp. e Aedes sp., publicados entre 2008 e 2020, relacionando os metabólitos isolados e já identificados com essa capacidade. Foram utilizadas para as pesquisas as bases de dados Scielo, Google Acadêmico, PubMed e Medline, resultando em 44 artigos dos quais foram selecionados 31 artigos conforme critérios de exclusão. Os resultados apontaram os gêneros Aspergillus, Fusarium e Penicillium com maior abrangência de estudos, com testes sobre as três principais espécies de mosquito citadas. Dentre os compostos isolados com potencial larvicida estão Palmarumicina B6, C8, C12, C15, Diepoxinas γ, δ, ζ, Peniciliumolida D e TMC-264, Dehidroaustina e Acetoxidehidroaustina, Hamisonina, Meleina, Esterigmatocistina, Secoesterigmatocistina e 13-hidroxiversicolorina B. Identificou-se também que há a necessidade de ampliação das pesquisas utilizando espécies de fungos endofíticos e de seus metabólitos para o controle destes mosquitos de interesse epidemiológico, haja vista os produtos de controle sintéticos apresentam diversos efeitos adversos ao homem e ao meio ambiente.

 

 


Keywords


Aedes sp., Culex sp., Anopheles sp., Culicídeos, Controle biológico, metabólitos secundários.

References


ABUTAHA, N. et al. Larvicidal activity of endophytic fungal extract of Cochliobolus spicifer (Pleosporales: Pleosporaceae) on Aedes caspius and Culex pipiens (Diptera: Culicidae). Applied Entomology and Zoology, v. 50, n. 3, p. 405 – 414. 2015.

ALGHUTHAYMI, A. et al. Myconanoparticles: synthesis and their role in phytopathogens management. Biotechnology & Biotechnological Equipment, v. 29, n. 2, p. 221 – 236, 2015.

ATHANASSIOU, C.G. et al. Nanoparticles for pest control: current status and future perspectives. Journal of Pest Science, v. 91, n. 1, p. 1 – 15, 2018.

BÜCKER, A. Atividade larvicida de fungos da Amazônia brasileira para o controle de mosquitos vetores de doenças. 2008. 87f. Dissertação (Mestrado em Biotecnologia e Recursos Naturais) – Programa de Pós-Graduação em Biotecnologia e Recursos Naturais, Universidade do Estado do Amazonas, Manaus, 2008.

BÜCKER, A. et al. Larvicidal effects of endophytic and basidiomycete fungus extracts on Aedes and Anopheles larvae (Diptera, Culicidae). Revista da Sociedade Brasileira de Medicina Tropical, v. 46, n. 4, p. 411 – 419, 2013.

DANAGOUDAR, A. et al. Antimicrobial and larvicidal potential of endophytic fungi isolated from Tragia involucrata Linn. Annals of Plant Science, v. 6, n. 1, p. 1494 – 1498, 2017.

DHANASEKARAN, D; THANGARAJ, R. Evaluation of larvicidal activity of biogenic nanoparticles against filariasis causing Culex mosquito vector. Asian Pacific Journal of Tropical Disease, v. 3, n. 3, p. 174 – 179, 2013.

DURAIRAJ, B.; MUTHU, S.; SHANTHI, P. Larvicidal potential of fungi based silver nanoparticles against Culex quinquefasciatus larvae (II and III Instar). Research and Reviews: Journal of Pharmacology and Toxicological Studies, v. 2, n. 4, p. 42 – 49, 2014.

ELUMALAI, D.; HEMALATHA, P.; KALEENA P. K. Larvicidal activity and GC–MS analysis of Leucas aspera against Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. Journal of the Saudi Society of Agricultural Sciences, v. 16, n. 4, p. 306 – 313, 2017.

GERIS, R. et al. Larvicidal effects of fungal meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and yellow fever. Chemistry & Biodiversity, v. 5, n. 2, p. 341 – 345, 2008.

KENDAGOR, A.C et al. Larvicidal activity of mellein from cultures of an ascomycete Pezicula livida against Aedes aegypti. International Journal of Life Science and Pharma Research, v. 2, n. 3, p. 70 – 80, 2013.

LAI, D. et al. Hyalodendriellins A-F, new 14-membered resorcylic acid lactones from the endophytic fungus Hyalodendriella sp. Ponipodef12. Royal Society of Chemistry Advances, v. 6, n. 110, p. 108989-109000.

MAO, Z. et al. Dibenzo-𝜶-pyrones: a new class of larvicidal metabolites against Aedes aegypti from the endophytic fungus Hyalodendriella sp. Ponipodef12. Pest Management Science, v. 73, n. 7, p. 1478 – 1485, 2017.

MAO, Z. et al. Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12. Molecules. v.25, n.114, 2020.

MATASYOH, J. C. et al. Larvicidal activity of metabolites from the endophytic Podospora sp. against the malaria vector Anopheles gambiae. Parasitology Research, v. 108, n. 3, p. 561 – 566, 2011.

PANDI, M. et al. Larvicidal activity of two extracts of endophitic fungi isolated from Pongamia pinata (L) Pierre. Indian Journal of Applied Microbiology, v. 8, n. 1, p. 34 – 36, 2008.

PRIYA, S; SANTHI S. A review on nanoparticles in mosquito control – a green revolution in future. International Journal for Research in Applied Science and Engineering Technology, v. 2, n. 12, p. 378 – 387, 2014.

RAGAVENDRAN, C.; NATARAJAN, D. Insecticidal potency of Aspergillus terreus against larvae and pupae of three mosquito species Anopheles stephensi, Culex quinquefasciatus, and Aedes aegypti. Environmental Science Pollution Research, v. 22, n. 21, p. 17224 – 17237, 2015.

RAGAVENDRAN, C. et al. Beauveria bassiana (Clavicipitaceae): a potente fungal agent for controlling mosquito vectors of Anopheles stephensi, Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). Royal Society of Chemistry Advances, v. 7, n. 7, p. 3838 – 3851, 2017.

RAJAMANIKYAM, M. et al. Endophytic fungi as novel resources of natural therapeutics. Brazilian Archives of Biology and Technology, v. 60, e17160542, 2017.

SALUNKHE, R.B. et al. Larvicidal potential of silver nanoparticles synthesized using fungus Cochliobolus lunatus against Aedes aegypti (Linnaeus, 1762) and Anopheles stephensi Liston (Diptera; Culicidae) Parasitology Research, v. 109, n. 3, p. 823 – 831, 2011.

SALUNKE, B. K. et al. Microorganisms as efficient biosystem for the synthesis of metalnanoparticles: current scenario and future possibilities. World Journal of Microbiology and Biotechnology, v. 32, n. 88, p. 1-16. 2016.

SATHIYANATHAN, M.; UMARAJAN, K. M. Larvicidal activity of endophytic fungi isolated from selected medicinal plants on Aedes aegypti. Journal of Pharmacognosy and Phytochemistry, v. 8, n. 2, p. 247 – 253, 2019.

SEETHARAMAN, P. et al. Isolation of limonoid compound (Hamisonine) from endophytic fungi Penicillium oxalicum LA-1 (KX622790) of Limonia acidissima L. for its larvicidal efficacy against LF vector, Culex quinquefasciatus (Diptera: Culicidae). Environmental Science Pollution Research, v. 24, n. 26, p. 21272 – 21282, 2017.

SEETHARAMAN, P. et al. Antimicrobial and larvicidal activity of eco-friendly silver nanoparticles synthesized from endophytic fungi Phomopsis liquidambaris. Biocatalysis and Agricultural Biotechnology, v. 16, p. 22 – 30, 2018.

SONI, N.; PRAKASH, S. Efficacy of fungus mediated silver and gold nanoparticles against Aedes aegypti larvae. Parasitology Research, v. 110, n. 1, p. 175 – 184, 2012a.

SONI, N.; PRAKASH, S. Synthesis of gold nanoparticles by the fungus Aspergillus niger and its efficacy against mosquito larvae. Reports in Parasitology, v. 2, p. 1 – 7, 2012b.

SONI, N.; PRAKASH, S. Fungus generated novel nanoparticles: a new prospective for mosquito control. International Journal of Recent Scientific Research, v. 4, n. 10, p. 1481 – 1487, 2013.

SUDHA, V. et al. Biological properties of endophytic fungi. Brazilian Archives of Biology and Technology, v. 59, e16150436, 2016.

TAKAGI, B. A. et al. Larvicidal and ovocidal effects of Crotalaria pallida extracts on the vector Aedes aegypti. Brazilian Journal of Development, v. 6, n.5, p. 23060-23074, 2020

TIAN, J. et al. Larvicidal spirobisnaphthalenes from the endophytic fungus Berkleasmium sp. against Aedes albopictus. Pest Management Science, v. 72, n. 5, p. 961-965, 2016.

ZHAO, X. et al. Fungal silver nanoparticles: synthesis, application and challenges. Critical Reviews In Biotechnology, v. 38, n. 6, p. 817 – 835, 2017.




DOI: https://doi.org/10.34117/bjdv6n6-205

Refbacks

  • There are currently no refbacks.