COVID-19: Origem do novo coronavirus/ COVID-19: Origin of the new coronavirus

Phelipe Magalhães Duarte

Abstract


O Comitê Internacional de Taxonomia de Vírus (ICTV) adotou síndrome respiratória aguda grave 2 (SARS-CoV-2) como nome para o novo vírus causador da COVID-19. O presente trabalho objetivou reunir informação sobre a possível origem do novo coronavírus (SARS-CoV-2). Realizou-se uma revisão de literária de trabalhos nacionais e internacionais publicados em revistas científicas eletrônicas e impressas, acessíveis através da web, além de livros. Estudos aponta que SARS-CoV-2 seja um vírus quimérico entre um coronavírus de morcego e um coronavírus de origem desconhecida. Uma das possibilidades aponta para o morcego sendo reservatório da SARS-CoV-2, transmitindo ao homem via pangolim. Pangolim-CoV é 91,02% e 90,55% idêntico ao SARS-CoV-2 e BatCoV RaTG13. Logo, é improvável que a origem do SARS-CoV-2 seja artificial, por manipulação laboratorial. Entretanto, ainda que remota, são necessárias maiores investigações para que se possa descartar uma provável liberação do SARS-CoV-2.


Keywords


COVID-19, SARS-CoV-2, Betacoronavirus.

References


ANDERSEN, K.G. et al. The proximal origin of SARS-CoV-2. Nat Med, v.26, n.4, p.450–452, 2020.

CHEN, Y; LIU, Q; GUO, D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J Med Virol, v.92, n.4, p.418‐423, 2020.

GORBALENYA, A.E. et al. Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group. 2020. Disponível em: https://www.biorxiv.org/content/10.1101/2020.02.07.937862v1.full.pdf. Acesso em: 22 abr. 2020.

HUANG, C. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, v.395, n.10223, p.497-506, 2020.

JI, W. et al. Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross‐species transmission from snake to human. J Med Virol. v.92, n.4, p.433‐440. 2020.

LAM, T.T.Y. et al. Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China. bioRxiv preprint first posted online. 2020. Disponível em: https://www.biorxiv.org/content/10.1101/2020.02.13.945485v1.full.pdf. Acesso em 23 abr. 2020.

LAU, S.K.P. et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl. Acad. Sci. USA, v.102, n.39, p.14040–14045, 2005.

LI, Q. et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-Infected pneumonia. N Engl J Med, v.382, n.13, p.1199-1207, 2020.

LI, W. et al. Bats are natural reservoirs of SARS-like coronaviruses. Science, v.310, n.5748, pp. 676-679, 2005.

LIM, P. L. et al. Laboratory-acquired severe acute respiratory syndrome. N Engl J Med, v.350, n.17, p.1740-1745, 2004.

LIU, P; CHEN, W; CHEN, J.-P. Viral metagenomics revealed sendai virus and coronavirus infection of Malayan Pangolins (Manis javanica). Viruses, v.11, n.11, p.979, 2019.

LU, R. et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, v.395, n.10224, p.565-574, 2020.

MEMISH, Z.A. et al. Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia. Emerging Infectious Diseases, v.19, n.11, p.1819-1823, 2013.

RICHMAN, D.D; WHITLEY, R.J; HAYDEN, F.G. Clinical Virology, 4. ed. Washington: ASM Press; 2016.

ROTTIER, P.J.M. The Coronavirus Membrane Glycoprotein. In: Siddell S.G. (eds) The Coronaviridae. The Viruses, Springer, Boston, MA; 1995. Disponível em: https://link.springer.com/chapter/10.1007/978-1-4899-1531-3_6. Acesso em: 22 abr. 2020.

TYRRELL, D.A; BYNOE, M.L. Cultivation of viruses from a high proportion of patients with colds. Lancet, v.287, n.7428, p.76–77, 1966.

XINHUA. China’s CDC detects a large number of new coronaviruses in the South China seafood market in Wuhan. 2020. Disponível em: http://www.xinhuanet.com/english/2020-01/27/c_138735677.htm. Acesso em 22 abr. 2020.

WOO, P.C. et al. Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronavirus as the gene source of gammacoronavirus and deltacoronavirus. Journal of Virology, v.86, n.7, p.3995-4008, 2012.

WORLD HEALTH ORGANIZATION. Coronavirus disease (COVID-19) outbreak. 2020. Disponível em: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Acesso em: 22 abr. 2020.

ZHANG, L. et al. Origin and evolution of the 2019 novel coronavirus. Clin Infect Dis, Diseases: an Official Publication of the Infectious Diseases Society of America, 2020. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167049/.

ZHANG, T; WU, Q; ZHANG, Z. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Current Biology, v.30, n.7, p.1346–1351, 2020.

ZHU, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med, v.382, n.8, p.727-733, 2020.




DOI: https://doi.org/10.34119/bjhrv3n2-187

Refbacks

  • There are currently no refbacks.