Is there a relationship between hippocampus-dependent memory and 5-ht2a receptors? Insights from a systematic review / Há uma relação entre a memória hipocampo-dependente e receptores 5-HT2a? Insights de uma revisão sistemática

Authors

  • Rafael Danyllo da Silva Miguel Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • José Elias Bezerra Barros
  • Gilmar Franca Nobre Junior
  • Isabella Cristinna da Silva Costa
  • José Emerson Xavier
  • Lisiane dos Santos Oliveira
  • Bruna Del Vechio Koike
  • Sandra Lopes de Souza

DOI:

https://doi.org/10.34119/bjhrv3n2-086

Keywords:

Memory, Hippocampus, Serotonin, 5-HT2A receptor

Abstract

This is a systematic review with the aim of analyzing the role of 5-HT2A receptors in hippocampal-dependent memory. In order to do this, we searched the PubMed, Science Direct, and Neuron databases between October 23 and 29, 2018, using the following descriptor combinations: memory, 5-HT2A, and hippocampus, present in the title, abstract, or keywords, with no restrictions on study date or language. Following search and selection, we analyzed risk of bias, and the results were subsequently synthesized according to the experimental model. Out of 40 articles, four were included in qualitative analysis. The data indicate that the 5-HT2A receptors in the hippocampus play an important role in the memory consolidation process, although they do not interfere in the encoding or retrieval processes of these memories. Additionally, chronic use of receptor agonists in models of Alzheimer’s disease also demonstrates better performance in the object recognition tests. The action of 5-HT2A receptors has also been shown to be important to aversive memory formation, thus attributing a prominent role to these receptors in hippocampal-dependent memory processes.

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Published

2020-03-26

How to Cite

MIGUEL, R. D. da S.; BARROS, J. E. B.; JUNIOR, G. F. N.; COSTA, I. C. da S.; XAVIER, J. E.; OLIVEIRA, L. dos S.; KOIKE, B. D. V.; SOUZA, S. L. de. Is there a relationship between hippocampus-dependent memory and 5-ht2a receptors? Insights from a systematic review / Há uma relação entre a memória hipocampo-dependente e receptores 5-HT2a? Insights de uma revisão sistemática. Brazilian Journal of Health Review, [S. l.], v. 3, n. 2, p. 2355–2373, 2020. DOI: 10.34119/bjhrv3n2-086. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/8095. Acesso em: 28 mar. 2024.

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Original Papers