Modulation of nitro-oxidative parameters in mice administered with very low doses of the iridoid plumieride / Modulação de parâmetros nitro-oxidativos em camundongos tratados com doses baixíssimas de plumierídeo

Ana Paula Dalmagro, Anderson Camargo, Priscila Laiz Zimath, Tiago José Bonomini, Angela Malheiros, Márcia Maria de Souza, Ana Lúcia Bertarello Zeni


Our group has been investigating the anti-inflammatory and antidepressant-like effects of plumieride (PLU 0.5, 1, 2 µg/Kg). However, there is no record in the literature about the in vivo antioxidant activity of PLU at very low doses, which could be linked with pharmacology effects. Here, we administered mice with vehicle and PLU 0.5, 1, or 2 µg/Kg for 7 days. Subsequently, we evaluated the modulation of lipoperoxidation, nitrite, protein carbonylation, and non-protein thiols triggered by PLU in mice’s brain, plasma, liver, and kidneys. Our results support, at least in part, the pharmacological potential that has been attributed to iridoid.


Plumieride; iridoid; Allamanda cathartica; oxidative stress.

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