Evidências científicas sobre o tratamento cirúrgico da queratose actínica / Scientific evidence on the surgical treatment of actinic keratosis

Authors

  • Michele Andreza Fidelis Siqueira
  • Bruna Rosa Cretella
  • Cendi Soares Silveira
  • Thaís Alves Fagundes
  • Flávia Silva Guimarães
  • Bruno Tardin de Andrade
  • Arthur Barata Paviato
  • Maria Carolina Trancoso Souza
  • Renata França Ferreira
  • Camila Alves de Andrade Pereira
  • Alexandre Strapasson Boechat
  • Welsher Braga Ribeiro Chaves
  • Velton Braga Ribeiro Chaves
  • Pedro Henrique Sulz Marx

DOI:

https://doi.org/10.34119/bjhrv5n3-139

Keywords:

queratose actínica, tratamento, cirurgia.

Abstract

As queratoses actínicas são máculas, pápulas ou placas queratósicas ou escamosas resultantes da proliferação intraepidérmica de queratinócitos atípicos em resposta à exposição prolongada à radiação ultravioleta. As queratoses actínicas são uma preocupação porque a maioria dos CECs cutâneos que surgem de queratoses actínicas pré-existentes, e as queratoses actínicas que irão progredir para o CEC não podem ser distinguidas de queratoses actínicas que se resolverão espontaneamente ou persistirão, devido a esses fatores, a maioria dos estudos recomedam tratar rotineiramente as queratoses actínicas.  As opções de tratamento para queratose actínica  incluem terapias destrutivas direcionadas à lesão (por exemplo, cirurgia, crioterapia, dermoabrasão) e terapias direcionadas ao campo com medicamentos tópicos como fluorouracilimiquimod e  mebutato de ingenol, ou terapia fotodinâmica. As terapias de campo são indicadas para o tratamento de áreas com múltiplas queratoses actínicas, lesões subclínicas que não são detectadas por inspeção visual ou palpação e cancerização de campo.

References

Criscione VD, Weinstock MA, Naylor MF, et al. Actinic keratoses: Natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial. Cancer 2009; 115:2523.

Ceilley RI, Jorizzo JL. Current issues in the management of actinic keratosis. J Am Acad Dermatol 2013; 68:S28.

Noels EC, Hollestein LM, van Egmond S, et al. Healthcare utilization and management of actinic keratosis in primary and secondary care: a complementary database analysis. Br J Dermatol 2019; 181:544.

Dréno B, Amici JM, Basset-Seguin N, et al. Management of actinic keratosis: a practical report and treatment algorithm from AKTeam™ expert clinicians. J Eur Acad Dermatol Venereol 2014; 28:1141.

Weiss J, Menter A, Hevia O, et al. Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks. Cutis 2002; 70:22.

Heppt MV, Steeb T, Leiter U, Berking C. Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis. J Eur Acad Dermatol Venereol 2019; 33:863.

Gupta AK, Paquet M, Villanueva E, Brintnell W. Interventions for actinic keratoses. Cochrane Database Syst Rev 2012; 12:CD004415.

Coleman WP 3rd, Yarborough JM, Mandy SH. Dermabrasion for prophylaxis and treatment of actinic keratoses. Dermatol Surg 1996; 22:17.

Weiss ET, Brauer JA, Anolik R, et al. 1927-nm fractional resurfacing of facial actinic keratoses: a promising new therapeutic option. J Am Acad Dermatol 2013; 68:98.

Berman B, Shabbir AQ, MacNeil T, Knudsen KM. Variables in Cryosurgery Technique Associated With Clearance of Actinic Keratosis. Dermatol Surg 2017; 43:424.

Simon JC, Dominicus R, Karl L, et al. A prospective randomized exploratory study comparing the efficacy of once-daily topical 0.5% 5-fluorouracil in combination with 10.0% salicylic acid (5-FU/SA) vs. cryosurgery for the treatment of hyperkeratotic actinic keratosis. J Eur Acad Dermatol Venereol 2015; 29:881.

Hadley G, Derry S, Moore RA. Imiquimod for actinic keratosis: systematic review and meta-analysis. J Invest Dermatol 2006; 126:1251.

Ulrich M, Reinhold U, Skov T, et al. Histological examination confirms clinical clearance of actinic keratoses following treatment with ingenol mebutate 0·05% gel. Br J Dermatol 2017; 176:71.

Bettencourt MS. Effect of Field Treatment of Actinic Keratosis With Ingenol Mebutate Gel on the Identification of Lesions for Biopsy. J Drugs Dermatol 2015; 14:813.

Liew YCC, De Souza NNA, Sultana RG, Oh CC. Photodynamic therapy for the prevention and treatment of actinic keratosis/squamous cell carcinoma in solid organ transplant recipients: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2020; 34:251.

Published

2022-05-17

How to Cite

SIQUEIRA, M. A. F.; CRETELLA, B. R.; SILVEIRA, C. S.; FAGUNDES, T. A.; GUIMARÃES, F. S.; DE ANDRADE, B. T.; PAVIATO, A. B.; SOUZA, M. C. T.; FERREIRA, R. F.; PEREIRA, C. A. de A.; BOECHAT, A. S.; CHAVES, W. B. R.; CHAVES, V. B. R.; MARX, P. H. S. Evidências científicas sobre o tratamento cirúrgico da queratose actínica / Scientific evidence on the surgical treatment of actinic keratosis. Brazilian Journal of Health Review, [S. l.], v. 5, n. 3, p. 9645–9664, 2022. DOI: 10.34119/bjhrv5n3-139. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48136. Acesso em: 28 mar. 2024.

Issue

Section

Original Papers