A ten-year retrospective study of the clinical, sociodemographic, and survival characteristics of patients with oral and pharyngeal squamous cell carcinomas/ Estudo retrospectivo de dez anos das características clínicas, sociodemográficas e de sobrevida de pacientes com carcinomas epidermóides orais e faríngeos

Paulo Goberlanio de Barros Silva Doutor, Karine Cestaro Mesquita, Thinali Sousa Dantas, Antonio Ernando Carlos Ferreira Junior, Rafael Linard Avelar, Roque Soares Martins Neto, Mario Rogério Lima Mota, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa

Abstract


Objective: This study evaluated the epidemiological profile of patients diagnosed with squamous cell carcinoma, as well compared oral and pharyngeal lesions regarding the survival of these patients. Material and Methods: Convenience sampling was employed to select the participants, who had their medical records of the period 200-2009 investigated. Sociodemographic and clinical-pathological data were collected and correlated with site of the lesion, TMN classification, of the tumor, and survival of the patients. Fisher’s and Chi-square tests, Kaplan-Meir curve associated with the Long Rank Mantel-Cox test, and Cox’s regression for survival analysis were performed to evaluate the results. Results: Sixty-year-old illiterate females presented higher prevalence of oral cancer with a more severe lymphonodular infiltration, worse tumor staging, and chemo and radiotherapy treatment. Meanwhile, sixty-year-old illiterate males presented higher prevalence of pharyngeal cancer, lower rates of lymphonodular infiltration, and chirurgical treatment. The survival of the patients with oral cancer was correlated with the lymphonodular infiltration level, while for patients with pharyngeal cancer the survival was correlated with chirurgical treatment. Thus, head and neck cancer are still diagnosed belatedly, mainly when it affects the pharynx.Conclusion: Therefore, preventive and educative strategies, as well as amplification of access to health care should be considered targets for achieving reduction in the mortality rates of populations with oropharyngeal cancer.


Keywords


Mouth Neoplasms, Pharyngeal Neoplasms, Epidemiology, Survival Rate

Full Text:

PDF

References


dos Santos LCO, de Medeiros Batista O, Cangussu MCT. Characterization of oral cancer diagnostic delay in the state of Alagoas. Braz J Otorhinolaryngol. 2010; 76 : 416-422.

Leonardo O, Santos A, Dutra RA, Maria S, Tartaglia A. Oral Squamous Cell Carcinoma : A Retrospective Study of 740 Cases in a Brazilian Population. 2013;12(1):2-7.

van Monsjou HS, Schaapveld M, Hamming-Vrieze O, de Boer JP, van den Brekel MWM, Balm AJM. Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: A population-based study. Oral Oncol. 2015; 52:37-44.

McDonald JT, Johnson-Obaseki S, Hwang E, Connell C, Corsten M. The relationship between survival and socio-economic status for head and neck cancer in Canada. J Otolaryngol - Head Neck Surg. 2014; 43 : 2-7.

BRASIL, MS. CID-0: Classificação Internacional de Doenças para Oncologia, 3ª ed, São Paulo, Edusp, 2005 247p.

Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017; 67(1):51-64. doi: 10.3322/caac.21384. Epub 2016 Oct 19.

Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Curado MP, Ferlay J, Franceschi S, Rosenberg PS, et al. Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol. 2013; 31(36):4550-9.

van Monsjou HS, Schaapveld M, Hamming-Vrieze O, de Boer JP, van den Brekel MW, Balm AJ. Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: A population-based study. Oral Oncol. 2016; 52 : 37-44.

Guggenheimer J, Verbin RS, Johnson JT, Horkowitz CA, Myers EN. Factors delaying the diagnosis of oral and oropharyngeal carcinomas. Cancer. 1989 Aug 15;64(4):932-5.

Bhurgri Y, Bhurgri A, Hussainy AS, Usman A, Faridi N, Malik J, et al. Cancer of the Oral Cavity and Pharynx in Karachi - Identification of Potential Risk Factors. Asian Pacific J Cancer Prev. 2003; 4:125-130.

Osborne RF, Brown JJ. Carcinoma of the oral pharynx: An analysis of subsite treatment heterogeneity. Surg Oncol Clin N Am. 2004; 13 : 71-80.

Filho VW. The epidemiology of laryngeal cancer in Brazil. Sao Paulo Med J. 2004; 122 : 188-194.

Caplan DJ, Hertz-Picciotto I. Racial differences in survival of oral and pharyngeal cancer patients in North Carolina. J Public Health Dent. 1998; 58 : 36-43.

Crescenzi D , Laus M , Radici M , Croce A. TNM classification of oral cavity carcinomas: suggested modifications. 2015; 69(4):18-27.

Chen JY, Wu X, Hong CQ, Chen J, Wei XL, Zhou L, et al. Downregulated ECRG4 is correlated with lymph node metastasis and predicts poor outcome for nasopharyngeal carcinoma patients. Clin Transl Oncol. 2017; 19(1):84-90.

Roberts TJ, Colevas AD, Hara W, Holsinger FC, Oakley-Girvan I, Divi V Number of positive nodes is superior to the lymph node ratio and American Joint Committee on Cancer N staging for the prognosis of surgically treated head and neck squamous cell carcinomas. Cancer. 2016; 122(9):1388-97.

Ljøkjel B, Haave H, Lybak S, Aarstad HH, Karlsdottir A, Vintermyr OK, et al. The impact of HPV infection, smoking history, age and operability of the patient on disease-specific survival in a geographically defined cohort of patients with oropharyngeal squamous cell carcinoma. Acta Otolaryngol. 2014; 134(9) : 964-73.

Horne ZD, Glaser SM, Vargo JA, Ferris RL, Balasubramani GK, Clump DA, et al. Confirmation of proposed human papillomavirus risk-adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas.Cancer. 2016;122(13) : 2021-30.

Chen YK, Huang HC, Lin LM, Lin CC. Primary oral squamous cell carcinoma : an analysis of 703 cases in southern Taiwan. 1999; 35.




DOI: https://doi.org/10.34119/bjhrv2n6-022

Refbacks

  • There are currently no refbacks.