Genetic and epigenetic aspects related to malocclusion–report of cases of monozygotic twins / Aspectos genéticos e epigenéticos relacionados com relatório de malocclusão-caso de gêmeos monozigigóticos

Isabella Fernandes Carvalho, Juliana Ximenes Damasceno, José Luciano Pimenta Couto, Luiza Lassi de Araújo, Marcelo Sales Cavalcante, Rafael Linard Avelar, Fernanda Araújo Sampaio, Phillipe Nogueira Barbosa Alencar

Abstract


Introduction: The multifactorial etiology of malocclusion involves several factors such as genetic, epigenetic and environmental factors. Among various dental anomalies, the development of supernumerary teeth is also directly related to genetic factors and mesiodens is the most frequent type of anomaly. Case Report: Two monozygotic twin sisters, both of which presented mesiodens, but only one with associated anterior open bite. Supernumerary removal was performed in the two sisters, and the anterior open bite was treated with the use of a fixed palatine grid. Results: The case was finished with proper occlusion and intercuspidation, contemplating facial and dental esthetics. Conclusion: Observing the possible differences that occur in pairs of monozygotic twins, it can be concluded that the development of malocclusions is associated with an interaction between genetic, epigenetic and environmental factors. Thus, the diagnosis and treatment of malocclusion should be individualized for each patient.


Keywords


Twins, Monozigotic. Tooth, supranumerary. Epigenetic Repression.

References


Thomaz EBAF, Valença AMG. Prevalência de má-oclusão e fatores relacionados à sua ocorrência em pré-escolares da cidade de São Luís – MA – Brasil. RPG Rev Pós Grad. 2005;12(2):212-21.

Almeida RR, Almeida-Pedrin RR, Almeida MR, Garib DG, Almeida PCMR, Pinzan A. Prevalência das más oclusões: características hereditárias e congênitas, adquiridas, gerais, locais e proximais (hábitos bucais). Rev Dental Press Ortod Ortop Facial. 2000;5(6):107-29.

Almeida MR, Pereira ALP, Almeida RR, Almeida--Pedrin RR, Silva Filho OG. Prevalência de má oclusão em crianças de 7 a 12 anos de idade. Dental Press J Orthod. 2011 July-Aug;16(4):123-31.

Huh A, Horton MJ, Cuenco KT, Raoul G, Rowlerson AM, Ferri J, et al. Epigenetic influence of KAT6B and HDAC4 in the development of skeletal malocclusion. Am J Orthod Dentofacial Orthop. 2013 Oct;144(4):568-76.

Mas C, Frapier L. A genetic heritage; the same yet different: A comparative study in twins. International Orthodontics. 2017;15(3):483-497.

Rocha SCC, Vidigal BL, Pereira AC, Fonseca MS, Manzi FR. Etiologia, Diagnóstico e Tratamento do Mesiodens – Relato de Caso Clínico Atípico. Arq Bras Odontol. 2012;8(2):49-54.

Nunes KM, Medeiros MV, Ceretta LB, Simões PW, Azambuja FG, Sônego FGF, Pires, PDS. Dente supranumerário: revisão bibliográfica e relato de caso Clínico. Rev Odontol Univ Cid São Paulo. 2015 Jan-Apr;27(1):72-81.

Russell KA, Folwarczna MA. Mesiodens—diagnosis and management of a common supernumerary tooth. J Can Dent Assoc. 2003;69(6):362–366.

Gurgel CV, Cota ALS, Kobayashi TY, Silva SMB, Machado MAAM, Rios D, et al. Bilateral Mesiodens in Monozygotic Twins: 3D Diagnostic and Management. Case Rep Dent. 2013;2013.

Kim YY, Hwang J, Kim HS, Kwon HJ, Kim S, Lee JH, Lee JH .Genetic alterations in mesiodens as revealed by targeted NGS and gene co-occurrence network analysis. Oral Dis. 2017 Oct;23(7):966-972.

Gunduz, K., Celenk, P., Zengin, Z. & Sumer, P. 2008. Mesiodens: a radiographic study in children. J Oral Sci. 2008;50(3):287-91.

Seddon RP, Johnstone SC, Smith PB. Mesiodentes in twins: a case report and a review of the literature. Int J Paediatr Dent. 1997;7(3):177–184.

Cassetta M, Altieri F, Giordano A. Mirror imaging of impacted and supernumerary teeth in dizygotic twins: A case report. J Clin Exp Dent. 2015 Feb;7(1):e167–e169.

Townsend G, Hughes T, Luciano M, Brook A. Genetic and environmental influences on human dental variation: limitations and advantages of studies involving twins. Arch Oral Biol. 2009;54:S45–51.

Townsend G, Bockmann M, Hughes T, Brook A. Genetic, environmental and epigenetic influences on variation in human tooth number, size and shape. Odontology. 2012;100:1–9.

Hughes T, Bockmann M, Mihailidis S, Bennett C, Harris A, Seow WK, et al. Genetic, epigenetic, and environmental influences on dentofacial structures and oral health: ongoing studies of Australian twins and their families. Twin Res Hum Genet. 2013 Feb;16(1):43-51.

Cabrera CAG, Enlow DH. Crescimento e desenvolvimento craniofacial. In: Cabrera CAG, Cabrera MC. Ortodontia clínica. Curitiba: produções interativas, 1997; cap. 1, p 1-41.

Weber DM, Vares MA, Mota HB, Keske-Soares M. Desenvolvimento do sistema fonológico de gêmeos monozigóticos com desvio fonológico: correlação a fatores genéticos e ambientais. Rev CEFAC. 2007 Jan-Mar;9(1):32-39.

Lopes-Freire GM, Cárdenas ABC, Deza JEES, Ustrell-Torrent JM, Oliveira LB, Quesada Jr JRR. Exploring the association between feeding habits, non-nutritive sucking habits, and malocclusions in the deciduous dentition. Prog Orthod. 2015 Dec;16(43):1-7.

Reichert I, Figel P, Winchester L. Orthodontic treatment of anterior open bite: a review article—is surgery always necessary? Oral Maxillofac Surg. 2014 Sep;18(3):271-277.

Souza BS, Bichara LM, Guerreiro JF, Quintão CC, Normando D. Occlusal and facial features in Amazon indigenous: An insight into the role of genetics and environment in the etiology dental malocclusion. Arch Oral Biol. 2015 Sep;60(9):1177-86.

Consolaro A, Cardoso MA, Consolaro RB. "Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin. Dental Press J Orthod. 2017 Nov-Dec;22(6):28-34.

Odeh R, Townsend G, Mihailidis S, Lahdemaski R, Hughes T, Brook A. Infraocclusion: Dental development and associated dental variations in singletons and twins . Archives of oral biology. 2015;60:1394-1402.

Lei HH, Liu H, GE LH. PAX6 polymorphisms in 20 Chinese children with supernumerary teeth in the maxillary incisor area. Int J Paediatr Dent. 2011;21:271-7.

Carton A, Rees RT. Mirror image dental anomalies in identical twins. Br Dent J. 1987;162:193-94.

Colak H, Uzgur R, Tan E, Hamidi MM, Turkal M, Colak T. Investigation of prevalence and characteristics of mesiodens in a non-syndromic 11256 dental outpatients. Eur Rev Med Pharmacol Sci. 2013 Oct;17(19):2684-9.

Matsumoto MA, Romano FL, Ferreira JT, Valério RA. Open bite: diagnosis, treatment and stability. Braz Dent J. 2012;23(6):768-78.

Al Hamadi W, Saleh F, Kaddouha M. Orthodontic Treatment Timing and Modalities in Anterior Open Bite: Case Series Study. Open Dent J. 2017 Nov;11:581-594.

Slaviero T, Fernandes TM, Oltramari-Navarro PV, de Castro AC, Conti F, Poleti ML, Almeida MR. Dimensional changes of dental arches produced by fixed and removable palatal cribs: A prospective, randomized, controlled study. Angle Orthod. 2017 Mar;87(2):215-222.

Rossato PH, Fernandes TMF, Urnau FDA, de Castro AC, Conti F, de Almeida RR, Oltramari-Navarro PVP. Dentoalveolar effects produced by different appliances on early treatment of anterior open bite: A randomized clinical trial. Angle Orthod. 2018 Nov;88(6):684-691.




DOI: https://doi.org/10.34119/bjhrv2n5-071

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