Encefalopatia relacionada a covid-19: Uma revisão narrativa / Covid-19 related encephalopathy: A narrative review

Aline Domingues Barreto, Ana Letícia Paschoalin Nascimento, Fernanda Perez Rocha, Hertiquiano Jerônimo dos Santos Souza, Isabella Barony Macedo, Laura Eny Vidal Reis, Paula Fulgêncio Tanure Jardim, Iasmin Fontes Murta

Abstract


Introdução: O “novo coronavírus” da Síndrome Respiratória Aguda Grave 2 (SARS-CoV-2) foi descoberto na China em 2019, sendo responsável por causar o COVID-19. Essa doença pode afetar os sistemas respiratório, gastrointestinal e neurológico. Quanto às afecções neurológicas, os sintomas envolvem convulsões febris e encefalite, sendo a encefalopatia uma das principais manifestações do SNC nesses pacientes com a doença em fase avançada. Metodologia: Revisão sistemática nas bases de dados PubMed, SciELO e periódicos CAPES empregando-se os descritores encefalopatia e COVID-19. Resultados: Importantes associações foram encontradas entre a encefalopatia e os pacientes infectados com o coronavírus. Nesse sentido, mais da metade desses pacientes receberam o diagnóstico dessa afecção neurológica. Discussão: No COVID-19, a encefalopatia predomina como manifestação neurológica quando comparada ao AVC e encefalite. A resposta inflamatória contra o vírus faz parte da fisiopatologia da doença dando origem a alterações como hipóxia, isquemia e alterações metabólicas. Além disso, sua manifestação clínica envolve disfunção cerebral difusa, confusão mental, cefaléia, convulsões e delirium. Conclusão: Os pacientes infectados com a doença do coronavírus possuem vários sinais e sintomas neurológicos, sendo a encefalopatia mais incidente, fazendo-se necessário cuidados intensivos.


Keywords


COVID-19, Encefalopatia e Brain Disease.

References


ABILDÚA, MJ Abenza et al. Encefalopatías y encefalitis durante la infección aguda por SARS-CoV2. Registro de la Sociedad Española de Neurología SEN COVID-19. Neurología, v. 36, n. 2, p. 127-134, 2021.

ANTONY, A.R.; Haneef, Z. Systematic review of EEG findings in 617 patients diagnosed with COVID-19. SEIZURE v. 83, 234–241, 2020.

ASADI-POOYA, A. A.; SIMANI, L. Central nervous system manifestations of COVID-19: A systematic review. Journal of the Neurological Sciences. v. 413:116832. Abr 2020.

BERLIT, Peter et al. “Neurological manifestations of COVID-19” - guideline of the German society of neurology. Neurological Research And Practice, [S.L.], v. 2, n. 1, dez. 2020.

DE MELO ESPÍNDOLA, Otávio et al. Patients with COVID-19 and neurological manifestations show undetectable SARS-CoV-2 RNA levels in the cerebrospinal fluid. International Journal of Infectious Diseases, v. 96, p. 567-569, 2020.

DESFORGES M. et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses. v. 12, p. 44-48. Jul 2019.

ELLUL, M. et al. Neurological associations of COVID-19. The Lancet Neurology, v. 8 p. 1-17. Jul 2020.

FILATOV, Asia et al. Neurological complications of coronavirus disease (COVID-19): encephalopathy. Cureus, v. 12, n. 3, 2020.

GUERRERO, Juan I et al. “Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings.” BMC infectious diseases. Vol. 21,n. 1, p. 515. 2 Jun. 2021.

KATAL, S. et al. Neuroimaging findings in COVID-19: A narrative review. Neuroscience Letters. Journal Pre-proof. Vol 8, p. 1-3. Out 2020.

KOUTROMANIDIS, M. et al.. Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy. Clinical Neurophysiology. Set. 2020.

KOPAŃSKA, M et al. “Changes in EEG Recordings in COVID-19 Patients as a Basis for More Accurate QEEG Diagnostics and EEG Neurofeedback Therapy: A Systematic Review.” Journal of clinical medicine v. 10, n. 6, p. 1300.

KREMER S, et al. Brain MRI findings in severe COVID-19: a retrospective observational study.J Radiology. Jun 2020.

LUIGETTI, M. et al. Assessment of neurological manifestations in hospitalized patients with COVID-19. European Journal of Neurology. V. 0, p. 1–7. Jul 2020.

MAO L. et al. Neurologic manifestations of hospitalized patients with coronavirus disease. JAMA. V.2 p.1-9, 2020.

MONTALVA. et al. . Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. Clinical Neurology and Neurosurgery. V.0 p. 194-202 Jul 2020.

PASINI, E et al. EEG achados em COVID-19 related encephalopathy. Clin. Neurophysiol. v, 131 , p. 2265-2267, 2020

ORRÙ, G. et al. Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review. International Journal of Environmental Research and Public Health. Vol. 17, 6688. Set. 2020.

ROSS W. et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain. V. 143, p 3104–3120, Oct2020.

SHAH, Parth et al. Encephalopathy in COVID-19 Patients. Cureus, v. 13, n. 7, 2021.

YACHOU Y, et al. Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci. v.41, pg.2657–2669, 2020




DOI: https://doi.org/10.34119/bjhrv4n5-214

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