Enxerto ósseo com rhBMP-2 em pacientes com fissuras labiopalatinas: análise histológica / rhBMP-2 alveolar bone graft in individuals with cleft lip and palate: histological analysis

Authors

  • Taylline das Mercês Gonçalves Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Rafael Almeida Monteiro
  • Maria da Conceição Andrade de Freitas
  • Nilton Cesar Nogueira dos Santos
  • Adna Barros Ismerim
  • Daniela Gamba Garib
  • Roberta Martinelli Carvalho
  • Terumi Okada Ozawa

DOI:

https://doi.org/10.34119/bjhrv4n5-052

Keywords:

Fissura labiopalatina, Enxerto ósseo, rhBMP-2.

Abstract

Este estudo avaliou histologicamente os tecidos ósseos removidos da região da fissura alveolar enxertada com rhBMP-2 em pacientes com fissuras labiopalatinas, 6 a 46 meses após a cirurgia. O grupo experimental foi composto por 13 pacientes com caninos retidos na região alveolar enxertada com rhBMP-2 (Infuse®). O grupo controle foi composto por seis pacientes com caninos retidos na região alveolar contralateral ou próxima à fissura não enxertada e um com canino retido na área enxertada com osso autógeno da crista ilíaca. No ato da exposição cirúrgica do canino, 6 a 46 meses após o enxerto ósseo secundário, as biópsias dos tecidos ósseos foram retiradas e submetidas a análise histológica pela técnica hematoxilina e eosina. Os cortes microscópicos do grupo experimental (n=12) evidenciaram fragmentos de tecido ósseo viável, com osteócitos normais em lacunas, osteoblastos na superfície óssea e espaços medulares preenchidos por tecido conjuntivo fibroso e vasos sanguíneos. O quadro histológico das biópsias de tecido ósseo removidas num período de 6 a 9 meses de enxertia evidenciaram trabéculas ósseas mais desorganizadas, sem formações lamelares e com maior densidade de osteócitos por área, indicando menor grau de maturidade óssea. As do período 24 a 46 meses eram compostas somente por tecido ósseo maduro de arranjo lamelar contendo linhas de reversão/incrementais e lacunas de osteócitos. Os fragmentos de tecidos ósseos removidos da área da fissura enxertada com rhBMP-2 apresentaram morfologia histológica normal, assemelhando-se com as características teciduais do grupo controle.

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Published

2021-09-08

How to Cite

GONÇALVES, T. das M.; MONTEIRO, R. A.; DE FREITAS, M. da C. A.; DOS SANTOS, N. C. N.; ISMERIM, A. B.; GARIB, D. G.; CARVALHO, R. M.; OZAWA, T. O. Enxerto ósseo com rhBMP-2 em pacientes com fissuras labiopalatinas: análise histológica / rhBMP-2 alveolar bone graft in individuals with cleft lip and palate: histological analysis. Brazilian Journal of Health Review, [S. l.], v. 4, n. 5, p. 19128–19147, 2021. DOI: 10.34119/bjhrv4n5-052. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/35617. Acesso em: 29 mar. 2024.

Issue

Section

Original Papers