Doenças extra gástricas associadas à infecção por Helicobacter pylori: uma revisão integrativa / Extra gastric diseases associated with Helicobacter pylori infection: an integrative review

Authors

  • Kariny Brito Montalvão Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Larissa de Oliveira Rosa Marques
  • Megmar Aparecida dos Santos Carneiro
  • Fábio Silvestre Ataides
  • Antonio Márcio Teodoro Cordeiro Silva
  • Nara Rúbia Rodrigues do Nascimento Silva
  • Ana Cláudia Alves de Oliveira Santos
  • Xisto Sena Passos
  • Milton Camplesi Junior
  • Juliana Menara de Souza Marques
  • Lucas Luiz de Lima Silva

DOI:

https://doi.org/10.34119/bjhrv4n5-023

Keywords:

Helicobacter pylori, doenças extra gástricas e desencadadas.

Abstract

Helicobacter pylori é uma bactéria Gram negativa, microaerófila, móvel, não esporulada capaz de colonizar a mucosa gástrica de humanos. A infecção por esse microrganismo  provoca alterações gástricas e extra gástricas devido ao processo inflamatório crônico que pode promover um efeito sistêmico e provocar rompimento da homeostase de diversos órgãos e tecidos, desencadeando diversas patologias. O objetivo desse trabalho foi realizar o levantamento bibliográfico de patologias não gástricas que são desencadeadas pela infecção crônica por H. pylori, considerando a fisiopatologia e os efeitos sistêmicos no hospedeiro. Para isso foi realizada uma revisão da literatura integrativa, de característica qualitativa, nas bases de dados Scientific Eletronic Library Online (SCIELO), Google Acadêmico, LilACS e NCBI PubMed. Foram incluídos artigos publicados em português, espanhol e inglês, no período de 2010 a 2020 que abordavam a temática e os critérios de exclusão foram teses, monografias e dissertações, e artigos que não abordavam o tema. Foram identificados alguns grupos de doenças não gástricas associadas à infecção por H. pylori, incluindo doenças hematológicas, neurológicas, hepatobiliares, respiratórias, vasculares, alérgicas, neoplásicas, metabólicas, oculares, bucais e autoimunes. O efeito sistêmico à infecção por H. pylori, onde são liberadas diversas citocinas e mediares químicos, provoca alterações e desequilíbrios homeostático em diferentes tecidos e órgãos extra gástricos do organismo, e muitas vezes ocorre uma resposta imunológica exacerbada. Apesar de não ser um consenso entre os trabalhos pesquisados, verificou-se que a infecção por H. pylori pode estar associada ao surgimento e progressão dessas diferentes patologias.



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Published

2021-09-02

How to Cite

MONTALVÃO, K. B.; MARQUES, L. de O. R.; CARNEIRO, M. A. dos S.; ATAIDES, F. S.; SILVA, A. M. T. C.; SILVA, N. R. R. do N.; SANTOS, A. C. A. de O.; PASSOS, X. S.; JUNIOR, M. C.; MARQUES, J. M. de S.; SILVA, L. L. de L. Doenças extra gástricas associadas à infecção por Helicobacter pylori: uma revisão integrativa / Extra gastric diseases associated with Helicobacter pylori infection: an integrative review. Brazilian Journal of Health Review, [S. l.], v. 4, n. 5, p. 18734–18757, 2021. DOI: 10.34119/bjhrv4n5-023. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/35451. Acesso em: 28 mar. 2024.

Issue

Section

Original Papers