Doenças extra gástricas associadas à infecção por Helicobacter pylori: uma revisão integrativa / Extra gastric diseases associated with Helicobacter pylori infection: an integrative review

Kariny Brito Montalvão, Larissa de Oliveira Rosa Marques, Megmar Aparecida dos Santos Carneiro, Fábio Silvestre Ataides, Antonio Márcio Teodoro Cordeiro Silva, Nara Rúbia Rodrigues do Nascimento Silva, Ana Cláudia Alves de Oliveira Santos, Xisto Sena Passos, Milton Camplesi Junior, Juliana Menara de Souza Marques, Lucas Luiz de Lima Silva

Abstract


Helicobacter pylori é uma bactéria Gram negativa, microaerófila, móvel, não esporulada capaz de colonizar a mucosa gástrica de humanos. A infecção por esse microrganismo  provoca alterações gástricas e extra gástricas devido ao processo inflamatório crônico que pode promover um efeito sistêmico e provocar rompimento da homeostase de diversos órgãos e tecidos, desencadeando diversas patologias. O objetivo desse trabalho foi realizar o levantamento bibliográfico de patologias não gástricas que são desencadeadas pela infecção crônica por H. pylori, considerando a fisiopatologia e os efeitos sistêmicos no hospedeiro. Para isso foi realizada uma revisão da literatura integrativa, de característica qualitativa, nas bases de dados Scientific Eletronic Library Online (SCIELO), Google Acadêmico, LilACS e NCBI PubMed. Foram incluídos artigos publicados em português, espanhol e inglês, no período de 2010 a 2020 que abordavam a temática e os critérios de exclusão foram teses, monografias e dissertações, e artigos que não abordavam o tema. Foram identificados alguns grupos de doenças não gástricas associadas à infecção por H. pylori, incluindo doenças hematológicas, neurológicas, hepatobiliares, respiratórias, vasculares, alérgicas, neoplásicas, metabólicas, oculares, bucais e autoimunes. O efeito sistêmico à infecção por H. pylori, onde são liberadas diversas citocinas e mediares químicos, provoca alterações e desequilíbrios homeostático em diferentes tecidos e órgãos extra gástricos do organismo, e muitas vezes ocorre uma resposta imunológica exacerbada. Apesar de não ser um consenso entre os trabalhos pesquisados, verificou-se que a infecção por H. pylori pode estar associada ao surgimento e progressão dessas diferentes patologias.




Keywords


Helicobacter pylori, doenças extra gástricas e desencadadas.

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DOI: https://doi.org/10.34119/bjhrv4n5-023

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