Critical oral diseases in rheumatoid arthritis: knowing, understanding and preventing / Lesões bucais importantes na artrite reumatoide: conhecer, compreender e prevenir

Victória Boëchat Feyo, Paula Karoline Fonseca, Viviane Angelina de Souza, Ariane Cezano de Oliveira Reis, Rafael de Oliveira Fraga, Maria das Graças Afonso Miranda Chaves, Priscila de Faria Pinto, Gisele Maria Campos Fabri

Abstract


Rheumatoid Arthritis (RA) is a chronic multifactorial disease characterized by inflammation of the synovial membranes that line the joints and affect 1% of the world population. This narrative review aims to discuss a highlight mechanisms about the main oral manifestations in patients with rheumatoid arthritis researching epidemiological data. This narrative review was performed by searching the literature on the MEDLINE / PubMed databases for articles in English focused on oral diseases in patients with RA. Scientific studies show that RA patients are at high risk of developing oral changes, for example, periodontal disease (PD), Sjögren's syndrome (SS), xerostomia and temporomandibular joint disorder (TMD). There is a complex interrelation between oral diseases and RA, with sufficient scientific evidence to assure that there is an association that is bidirectional and impacts the pathogenesis and evolution of these conditions. This bidirectional connection with effects on the inflammatory profile of individuals reinforces the need for future clinical studies that confirm the effectiveness of prevention and early diagnosis protocols for rheumatological disease and the main associated oral diseases.


Keywords


dentistry, oral complication, salivary gland, rheumatoid arthritis.

References


Crincoli V, Anelli MG, Quercia E, Piancino MG, Di Comite M. Temporomandibular Disorders and Oral Features in Early Rheumatoid Arthritis Patients: An Observational Study. Int J Med Sci 2019;16(2):253–63.

de Molon RS, Rossa C Jr, Thurlings RM, Cirelli JA, Koenders MI. Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions. Int J Mol Sci 2019;20(18):4541.

Silvestre-Rangil J, Bagán L, Silvestre FJ, Bagán JV. Oral Manifestations of Rheumatoid Arthritis. A Cross-Sectional Study of 73 Patients. Clin Oral Investig 2016;20(9):2575–80.

Kaur S, White S, Bartold M. Periodontal Disease as a Risk Factor for Rheumatoid Arthritis: A Systematic Review. JBI Libr Syst Rev 2012;10(42):1–12.

Burmester GR, Pope JE. Novel Treatment Strategies in Rheumatoid Arthritis. Lancet 2017;389(10086):2338–48.

Rodríguez-Lozano B, González-Febles J, Garnier-Rodríguez JL, et al. Association Between Severity of Periodontitis and Clinical Activity in Rheumatoid Arthritis Patients: A Case-Control Study. Arthritis Res Ther 2019;21(1):27.

Ahola K, Saarinen A, Kuuliala A, Leirisalo-Repo M, Murtomaa H, Meurman JH. Impact of Rheumatic Diseases on Oral Health and Quality of Life. Oral Dis 2015;21(3):342–8.

Takahashi H, Tsuboi H, Yokosawa M, et al. Diffusion-Weighted Magnetic Resonance Imaging of Parotid Glands Before and After Abatacept Therapy in Patients with Sjögren's Syndrome Associated with Rheumatoid Arthritis: Utility to Evaluate and Predict Response to Treatment. Mod Rheumatol 2018;28(2):300–7.

Tong Y, Zheng L, Qing P, et al. Oral Microbiota Perturbations are Linked to High Risk for Rheumatoid Arthritis. Front Cell Infect Microbiol 2020;9:475.

Cetinkaya B, Guzeldemir E, Ogus E, Bulut S. Proinflammatory and Anti-Inflammatory Cytokines in Gingival Crevicular Fluid and Serum of Patients with Rheumatoid Arthritis and Patients with Chronic Periodontitis. J Periodontol 2013;84(1):84–3.

Corrêa JD, Fernandes GR, Calderaro DC, et al. Oral Microbial Dysbiosis Linked to Worsened Periodontal Condition in Rheumatoid Arthritis Patients. Sci Rep 2019;9(1):8379.

Graves DT, Corrêa JD, Silva TA. The Oral Microbiota Is Modified by Systemic Diseases. J Dent Res 2019;98(2):148–56.

Eriksson K, Fei G, Lundmark A, et al. Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis. J Clin Med 2019;8(5):630.

Silvestre-Rangil J, Bagán L, Silvestre FJ, Bagán JV. Oral Manifestations of Rheumatoid Arthritis. A Cross-Sectional Study of 73 Patients. Clin Oral Investig 2016;20(9):2575–80.

Faria JB, Furtado TCS, Bertoldo BB, Amaral EP, Silva CB, Pereira SAL. Relationship between periodontitis, joint diseases and smoking in patients who will undergo dental implants. Braz. J. Hea. Rev. 2020; 3(1):114 – 132.

Chamani G, Shakibi MR, Zarei MR, et al. "Assessment of Relationship Between Xerostomia and Oral Health-Related Quality of Life in Patients with Rheumatoid Arthritis". Oral Dis 2017;23(8):1162–7.

Mühlberg S, Jäger J, Krohn-Grimberghe B, et al. Oral Health-Related Quality of Life Depending on Oral Health in Patients with Rheumatoid Arthritis. Clin Oral Investig 2017;21(9):2661–70.

Savioli C, Ribeiro AC, Fabri GM, et al. Persistent Periodontal Disease Hampers Anti-Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis. J Clin Rheumatol 2012;18(4):180-4.

Martinez-Martinez RE, Domínguez-Pérez RA, Sancho-Mata J, Abud-Mendoza C, Ayala-Herrera JL, Popoca-Hernandez EA. The Frequency and Severity of Dental Caries, and Counts of Cariogenic Bacteria in Rheumatoid Arthritis Patients. Dent Med Probl 2019;56(2):137–42.

Das S, Huynh D, Yang H, Ceponis A, Kavanaugh A. Salivary Gland Ultrasonography as a Diagnostic Tool for Secondary Sjögren Syndrome in Rheumatoid Arthritis. J Rheumatol 2015;42(7):1119-22.

Hamani G, Shakibi MR, Zarei MR, et al. "Assessment of Relationship Between Xerostomia and Oral Health-Related Quality of Life in Patients with Rheumatoid Arthritis". Oral Dis 2017;23(8):1162-7.

Harrold LR, Shan Y, Rebello S, et al. Prevalence of Sjögren's Syndrome Associated with Rheumatoid Arthritis in the USA: An Observational Study From the Corrona Registry. Clin Rheumatol 2020; 39(6):1899-905.

Hajiabbasi A, Shenavar Masooleh I, Alizadeh Y, Banikarimi AS, Ghavidel Parsa P. Secondary Sjogren's Syndrome in 83 Patients with Rheumatoid Arthritis. Acta Med Iran 2016;54(7):448-53.

Stefanski AL, Tomiak C, Pleyer U, Dietrich T, Burmester GR, Dörner T. The Diagnosis and Treatment of Sjögren's Syndrome. Dtsch Arztebl Int 2017;114(20):354-61.

Lin CY, Chung CH, Chu HY, et al. Prevalence of Temporomandibular Disorders in Rheumatoid Arthritis and Associated Risk Factors: A Nationwide Study in Taiwan. J Oral Facial Pain Headache 2017;31(4):29-36.

Savtekin G, Sehirli AO. Rheumatoid Arthritis in Temporo-Mandibular Joint: A Review. Niger J Clin Pract 2018;21(10):1243-6.

Cordeiro PC, Guimaraes JP, de Souza VA, et al. Temporomandibular Joint Involvement in Rheumatoid Arthritis Patients: Association Between Clinical and Tomographic Data. Acta Odontol Latinoam 2016;29(3):123-9.

Kurtoglu C, Kurkcu M, Sertdemir Y, Ozbek S, Gürbüz CC. Temporomandibular Disorders in Patients with Rheumatoid Arthritis: A clinical Study. Niger J Clin Pract 2016;19(6):715?20.

Pantoja LLQ, de Toledo IP, Pupo YM, et al. Prevalence of Degenerative Joint Disease of the Temporomandibular Joint: A Systematic Review. Clin Oral Investig 2019;23(5):2475?88.

Äyräväinen L, Leirisalo-Repo M, Kuuliala A, et al. Periodontitis in Early and Chronic Rheumatoid Arthritis: A Prospective Follow-Up Study in Finnish Population. BMJ Open 2017;7(1).

Choi IA, Kim JH, Kim YM, et al. Periodontitis is Associated with Rheumatoid Arthritis: A Study with Longstanding Rheumatoid Arthritis Patients in Korea. Korean J Intern Med 2016;31(5):977-86.

Eriksson K, Nise L, Kats A, et al. Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study. PLoS One 2016;11(5).

Huang LG, Chen G, Chen DY, Chen HH. Factors Associated with The Risk of Gingival Disease in Patients with Rheumatoid Arthritis. PLoS One 2017; 12 (10).

Kim JH, Choi IA, Lee JY, et al. Periodontal Pathogens and the Association Between Periodontitis and Rheumatoid Arthritis in Korean Adults. J Periodontal Implant Sci 2018;48(6):347-59.

Kordtabar S, Aghaie M, Fakhari E, Vakili MA. Periodontal Condition in Patients with Rheumatoid Arthritis: Effect of Anti-Rheumatic Drugs. J Dent (Shiraz) 2019; 20 (3): 190-4.

Lugonja B, Yeo L, Milward MR, et al. Periodontitis Prevalence and Serum Antibody Reactivity to Periodontal Bacteria in Primary Sjögren's Syndrome: A Pilot Study. J Clin Periodontol 2016;43(1):26?33.

Pons-Fuster A, Rodríguez Agudo C, Galvez Muñoz P, Saiz Cuenca E, Pina Perez FM, Lopez-Jornet P. Clinical Evaluation of Periodontal Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study. Quintessence Int 2015;46(9):817-22.

Zhao R, Gu C, Zhang Q, et al. Periodontal Disease in Chinese Patients with Rheumatoid Arthritis: A case-control Study Oral Dis. 2019;25(8):2003?9.

Brown LE, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Liao KP. Clinical Characteristics of RA Patients with Secondary SS and Association with Joint Damage. Rheumatology (Oxford) 2015;54(5):816-20.

Sakr BR, Elfishawi MM, Elarousy MH, et al. Rheumatoid arthritis: A Single-Center Egyptian Experience. Immunol Invest 2018;47(3):293?302.

Santosh K, Dhir V, Singh S, et al. Prevalence of Secondary Sjögren's Syndrome in Indian Patients with Rheumatoid Arthritis: A Single-Center Study. Int J Rheum Dis 2017;20(7):870?4.

González-Chávez SA, Pacheco-Tena C, de Jesús Caraveo-Frescas T, Quiñonez-Flores CM, Reyes-Cordero G, Campos-Torres RM. Oral Health and Orofacial Function in Patients with Rheumatoid Arthritis. Rheumatol Int 2020;40(3):445-53.

Mortazavi N, Babaei M, Babaee N, Kazemi HH, Mortazavi R, Mostafazadeh A. Evaluation of the Prevalence of Temporomandibular Joint Involvement in Rheumatoid. Arthritis Using Research Diagnostic Criteria for Temporomandibular Disorders. J Dent (Tehran) 2018 ;15(6):332-8.




DOI: https://doi.org/10.34119/bjhrv4n4-163

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