Estudo comparativo do mecanismo de ação da Vitamina D na prevenção da artrite reumatóide e psoríase / Comparative study of the mechanism of action of Vitamin D in the prevention of rheumatoid arthritis and psoriasis

Karoline de Castro Batista, Omero Martins Rodrigues Junior, Salomão Rocha Martim

Abstract


A vitamina D (VitD) (colecalciferol) é uma molécula esteroide solúvel em gordura que é obtida tanto da ingestão alimentar quanto da síntese endógena, a deficiência de VitD está correlacionada com muitas condições clínicas e fisiopatológicas, bem como com o desenvolvimento e exacerbação de várias doenças autoimunes. Do mesmo modo, tem havido um interesse crescente em elucidar a relação entre VitD e a imunidade. Dessa forma, este estudo teve por objetivo realizar uma revisão da literatura a fim de descrever o mecanismo de ação da vitamina D na prevenção da artrite reumatoide e psoríase. O estudo foi realizado por meio dos bancos de dados: Google Acadêmico, Scielo - Scientific Electronic Library Online, Lilacs - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde, Pubmed - U. S. National Library of Medicine executando a busca do material que foi pesquisado por meio dos descritores: Vitamina D, Artrite Reumatoide, Psoríase e Doenças autoimunes. Estes termos foram utilizados em português e inglês no período de 2010 a 2021. Dado o papel proposto para a vitD como um regulador imunológico, talvez não seja surpreendente que a deficiência de vitD tenha sido associada a doenças alérgicas e autoimunes. Esta revisão elucidou o papel da vitamina-D na prevenção de doenças autoimunes. Como observado, foi descrito o metabolismo de formação da vitD, assim como os mecanismos de atuação na artrite reumatoide, psoríase e doença de Crohn.


Keywords


Artrite Reumatoide, Doenças autoimunes, Psoríase e Vitamina D.

References


BELLAN, M. et al. Role of Vitamin D in Rheumatoid Arthritis. Ultraviolet Light in Human Health. Diseases and Environment. v. 996, p. 155-168, 2017.

BIZZARO, G.; SHOENFELD, Y. Vitamin D and autoimmune thyroid diseases: facts and unresolved questions. Immunologic Research, v. 61, n. 1-2, p. 46-52, 2015.

BRAGAZZI, N. L. et al. Vitamin D and rheumatoid arthritis: an ongoing mystery. Current Opinion in Rheumatology. v. 29, n. 4, p. 378-388, 2017.

BUONDONNO, I. et al. Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized double-blind placebo-controlled study. Public Library of Science PLoS One. v. 5, n. 12, p. e0178463, 2017.

CALTON, E. K. et al. The impact of vitamin D levels on inflammatory status: a systematic review of immune cell studies. PLoS One, v. 10, n. 11, p. e0141770, 2015.

CAO, R. et al. 1,25(OH)2 D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation. Journal of Leukocyte Biology, v. 10, n. 1, p. 283-295, 2020.

CARLBERG, C. Vitamin D Signaling in the Context of Innate Immunity: Focus on Human Monocytes. Frontiers in Immunology, v. 13, n. 10, p. 2211, 2019.

CHAROENNGAM, N. et al. The ongoing D-lemma of vitamin D supplementation for nonskeletal health and bone health. Current Opinion in Endocrinology, Diabetes and Obesity. v. 26, p. 301–305, 2019.

CHAROENNGAM, N.; HOLICK M. F. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. v. 15, n. 12, p. 2097, 2020.

CHRISTAKOS, S. et al. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiological Reviews, v. 96, n. 1, p. 365-408, 2016.

CIANCIOLO, G. et al. Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients. Nutrients, v. 25, n. 13(5), p. 1453, 2021.

COLOTTA, F. et al. Modulation of inflammatory and immune responses by vitamin D. Journal of Autoimmunity,v. 85, p. 78-97, 2017.

COOLES, F. A. Et al. Retrospective analysis of the role of serum vitamin D in early rheumatic disease. Rheumatology (Oxford), v. 54, n. 2, p. 374-5, 2015.

DE LA TORRE LOSSA, P. et al. Vitamin D is not useful as a biomarker for disease activity in rheumatoid arthritis. Reumatology Clinical (Engl Ed),v. 2, n. 1):p. 110-115, 2020.

DENNIS, G. Jr. et al. Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics. Arthritis Research & Therapy, v. 16, n. 2, p. R90, 2014.

DI FRANCO, M. et al. Hypovitaminosis D in recent onset rheumatoid arthritis is predictive of reduced response to treatment and increased disease activity: a 12 month follow-up study. BMC Musculoskeletal Disorders, 15, n. 16, p. 53, 2015.

DIECKMANN, K. P. et al. Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients? Basic and Clinical Andrology. v. 10, p. 31(1), p. 14, 2021.

EL-MOATY ZAHER, H. A. et al. Assessment of interleukin-17 and vitamin D serum levels in psoriatic patients. Journal of the American Academy of Dermatology, v. 69, p. 840–2, 2013.

FAN, P. et al. Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis. Cellular Physiology and Biochemistry, 42,n. 1, p. 145-155, 2017.

FITCH, N. et al. Vitamin D [1,25(OH)2D3] Differentially Regulates Human Innate Cytokine Responses to Bacterial versus Viral Pattern Recognition Receptor Stimuli. Journal Immunology, v. 1, n. 196(7), p. 2965-72, 2016.

GARDNER, D. H. et al. 1,25(OH)2D3 promotes the efficacy of CD28 costimulation blockade by abatacept. Journal of Immunology, v. 195, p. 2657–2665, 2015.

GISONDI P, et al. Vitamin D status in patients with chronic plaque psoriasis. British Journal of Dermatology, v. 166, p. 505–10, 2012.

GRAZIO, S. et al. Vitamin D serum level, disease activity and functional ability in different rheumatic patients. The American Journal of the Medical Sciences, v. 349, n. 1, p. 46–9, 2015.

GU, X. et al. 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. Cell Death & Disease - Nature, v. 7, n. 10, p. e2423, 2016.

HARRISON, S. R. et al. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis. Calcified Tissue International. v. 106, n. 1, p. 58-75, 2020.

ISHIKAWA, L. L. W., et al. Vitamin D Deficiency and Rheumatoid Arthritis. Clinical Reviews in Allergy & Immunology, v. 52, n. 3, p. 373-388, 2016.

JEFFERY, L. E. et al. Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint. Journal of Immunology, v. 88, p. 50–60, 2018.

JEFFERY, L. E. et al. Vitamin D antagonises the suppressive effect of inflammatory cytokines on CTLA-4 expression and regulatory function. PLoS ONE, v. 2, n. 10(7), p. e0131539, 2015.

JEON, S. M.; SHIN, E. A. Exploring vitamin D metabolism and function in cancer. Experimental & Molecular Medicine, v. 16, n. 50(4), p. 1-14, 2018.

JOLLIFFE, D. A. et al. Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. 2020 Aug, v , 202, n. 3, p. 371-382, 2020.

KINCSE, G. et al. Vitamin D3 levels and bone mineral density in patients with psoriasis and/or psoriatic arthritis. Journal Dermatology, v. 42, n. 7, p. 679–84, 2015.

KIRSCHNER, N. et al. Tight junctions and differentiation – a chicken or the egg question? Experimental Dermatology - Wiley Online Library, v. 21, p. 171–5, 2012.

LEE, Y. H.; BAE, S. C. Vitamin D level in rheumatoid arthritis and its correlation with the disease activity: a meta-analysis. Clinical and Experimental Rheumatology. v. 34, n. 5, p. 827-833, 2016.

LI, D. et al. Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis. The Journal of Steroid Biochemistry and Molecular Biology, v. 187, p. 1-8, 2018.

LIU, D. et al. 1,25-(OH)2D3/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27. Cell Communication and Signaling, 10, n. 17, p. 163, 2019.

LIU, Y. et al. Regulatory Effect of 1,25(OH)2D3 on TGF-β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats. International Journal of Endocrinology, v. 3, n. 2019, p. 1231346, 2019.

LONNBERG, A. S.; SKOV, L. Co-morbidity in psoriasis: mechanisms and implications for treatment. Expert Review of Clinical Immunology, v. 28, p. 1–8., 2016.

MANCINI, P. et al. Hearing loss in autoimmune disorders: Prevalence and therapeutic options. Autoimmune Reviews. 17, n. 7, p. 644-652, 2018.

MARKS, D.J. Defective innate immunity in inflammatory bowel disease: a Crohn's disease exclusivity? Current Opinion in Gastroenterology, v. 27, p. 328-334, 2011.

MARTENS, P. J. et al. Vitamin D's Effect on Immune Function. Nutrients. 28, n. 12, p. 1248, 2020.

MARTINEAU, A. R. et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Family Medicine and Community Health – BMJ, v. 15, n. 356, p. i6583, 2017.

MATEEN, S. et al. Level of inflammatory cytokines in rheumatoid arthritis patients: Correlation with 25-hydroxy vitamin D and reactive oxygen species. PLoS One, v. 12, n. 6, p. e0178879, 2017.

MATHIEU, C. Vitamin D and diabetes: Where do we stand? Diabetes Research and Clinical Practice, v. 108, n. 2, p. 201-9, 2015.

MATTOZZI, C. et al. Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: an update. Journal Dermatology, v. 43, n. 5, p. 507–14, 2016.

MEENA, N. et al. Assessment of Vitamin D in Rheumatoid Arthritis and Its Correlation with Disease Activity. Journal of Natural Science, Biology and Medicine, v. 9, n. 1, p. 54-58, 2018.

MEHMOOD, Z. H.; PAPANDREOU, D. An updated mini review of vitamin Dand obesity:Adipogenesis and inflammation state. Open Access Macedonian Journal of Medical Sciences, v. 4, n. 3, p. 526–32, 2016.

NAPOLITANO, M. et al. Psoriatic arthritis and psoriasis: differential diagnosis. Clinical Rheumatology., v. 35, n. 8, p. 1893–901, 2016.

NEVE, A. et al. Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis. Clinical and Experimental Medicine. 2014;14(3):275–83.

ORGAZ-MOLINA, J. et al. Deficiency of serum concentration of 25- hydroxyvitamin D in psoriatic patients: a case-control study. Journal of the American Academy of Dermatology, v. 67, p. 931–8, 2012.

PRIETL, B. et al. Vitamin D and immune function. Nutrients. v. 5, p. 2502-2521, 2013.

RICHETTA, A. G. et al. A-1012G promoter polymorphism of vitamin D receptor gene is associated with psoriasis risk and lower allele-specific expression. DNA and Cell Biology. v. 33, n. 2, p. 102–9, 2014.

ROSEN, Y. et al. Vitamin D and autoimmunity. Scandinavian Jounal Rheumatology. v. 45, n. 6, p. 439-447, 2016

RUIZ-BALLESTEROS, A. L. et al. Association of Vitamin D Metabolism Gene Polymorphisms with Autoimmunity: Evidence in Population Genetic Studies. International Journal of Molecular Sciences, v. 17, n. 21(24), p. 9626, 2020.

SAPONARO, F. et al. An Update on Vitamin D Metabolism. International Journal of Molecular Sciences, v. 8, n. 21(18), p. 6573, 2020.

SASSI, F. et al. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. v. 10, n. 11, p. 1-14, 2018.

SOLEYMANI, T. et al. The role of vitamin D in psoriasis: a review, International Journal of Dermatology, v. 54, p. 383–392, 2015.

TRACY, A. et al. Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?. Seminars in Immunopathology, v. 39, p. 423–435, 2017.

VISCONTI, B. et al. Immunohistochemical expression of VDR is associated with reduced integrity of tight junction complex in psoriatic skin. The Journal of the European Academy of Dermatology and Venereology, v. 29, p. 2038–42, 2015.

WANG, S. et al. Recent Advances in Nanotheranostics for Treat-to-Target of Rheumatoid Arthritis. Advanced Healthcare Materials. 2020 Mar;v. 9, n. 6, p. e1901541, 2020.

XIA, Y. et al. 1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells. PLoS One, v. 18, n. 11(10), p. e0164717, 2016.

YANG, L. et al. 1,25(OH)2D3/VDR attenuates high glucose induced epithelial mesenchymal transition in human peritoneal mesothelial cells via the TGFβ/Smad3 pathway. Molecular Medicine Reports, v. 15, n. 4, p. 2273-2279., 2017.

YANG, M. et al. Anti-inflammatory effect of 1, 25dihydroxyvitamin D (3) is associated with crosstalk between signal transducer and activator of transcription 5 and the vitamin D receptor in human monocytes. Experimental and Therapeutic Medicine, v. 9, p. 1739–44, 2015.

ZHOU, Q. et al. 1,25(OH)2D3 induces regulatory T cell differentiation by influencing the VDR/PLC-γ1/TGF-β1/pathway. Molecular Immunology,v. 91, p. 156-164, 2017.

ZUCHI, M. F. et al. Serum levels of 25-hydroxy vitamin D in psoriatic patients. Anais Brasileiros de Dermatologia, v. 90, n. 3, p. 430–2, 2015.




DOI: https://doi.org/10.34119/bjhrv4n4-063

Refbacks

  • There are currently no refbacks.