Suplementação de vitamina d: uma estratégia no combate à covid-19? / Vitamin d supplementation: a strategy in combating covid-19?

Hugo Cardoso Pena, Samanta Hosokawa Dias de Novoa Rocha, Vitor Taveira Takahashi, Felipe Duarte Moraes, Fillipo Leite Santos, Juliana Katalinic Said Dutra

Abstract


A suplementação de vitamina D, como estratégia terapêutica, pode estar associada a benefícios na infecção pelo SARS-COV-2, considerando suas propriedades imunológicas que corroboram com a repressão de vias imunes pró-inflamatórias e estimulação de mecanismos anti-inflamatórios. De forma geral, os componentes do sistema imune que sofrem influência da vitamina D na COVID-19 são a imunidade inata, imunidade adaptativa, endotélio capilar e o sistema renina-angiotensina-aldosterona (SRAA). Populações de risco para hipovitaminose D apresentam maior taxa de infecção, como negros, asiáticos, residentes de locais de altas latitudes e locais com elevada poluição atmosférica, bem como sazonalmente no inverno. Estudos recentes demonstram desfechos favoráveis para pacientes submetidos a terapias com vitamina D, apresentando ganhos significativos quanto a mortalidade, necessidade de suporte intensivo e oxigenioterapia. Essa é uma revisão narrativa da literatura acerca da relação da suplementação da vitamina D, bem como de situações de hipovitaminose; e seu reflexo na história natural da doença da COVID-19.


Keywords


Vitamina D, COVID-19, sistema imune, hipovitaminose D

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DOI: https://doi.org/10.34119/bjhrv4n3-119

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