Uso de Inibidores de Janus Kinase no tratamento da Artrite Reumatoide / Use of Janus Kinase Inhibitors in the treatment of Rheumatoid Arthritis

Authors

  • Gabriel Monici Vieira Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Débora Oliveira Piva
  • Giovanni Pereira Pio
  • Rafaela Lucas Damasceno
  • Ricardo de Villa Nova Japiassu
  • Anamaria Camargo Macedo
  • Luís Piva Júnior

DOI:

https://doi.org/10.34119/bjhrv4n3-009

Keywords:

Inibidores de Janus Kinase, Artrite Reumatoide, Treatment.

Abstract

A artrite reumatoide é uma patologia autoimune relacionada a produção excessiva de citocinas inflamatórias, fator de necrose tumoral (TNF) e células T reativas, cursando com destruição articular progressiva, sinovite inflamatória crônica e manifestações em múltiplos órgãos. O tratamento evolucionário da patologia se resumia em drogas com ação anti-inflamatória e drogas antirreumáticas modificadoras de doença sistêmica biológica, as quais atuavam nos alvos de interleucinas inflamatórias e fatores de necrose tumorais (TNF). Apesar de uma boa remissão inicial, não eram totalmente eficazes e apresentavam vários efeitos colaterais. Com o advento do estudo sobre o genoma humano foi possível a identificação de quinases de sinalização, as quais fazem parte as Janus quinases (JAK), as mesmas desempenham a função de ativar as STAT´s e, consequentemente, seu transporte até o núcleo celular e a transdução de novos genes dependentes que influenciarão na fisiopatologia da AR. Medicamentos são estudados para inativação da ação das JAK´s, com o sucesso do Tofacitinibe, seletivo para JAK1 e JAK3, e com maior tolerabilidade e eficácia em comparação com os MMCD´s biológicos e Metotrexato. Fazem parte dessa nova classe as medicações Baricitinibe e Upadacitinibe. Esse estudo objetiva a análise comparativa entre medicamentos utilizados anteriormente para artrite reumatoide e os Inibidores de Janus Kinases. Iniciando uma breve exploração entre os principais fármacos que compõem a família dos Inibidores de Janus Kinases e a importância da nova possibilidade terapêutica para artrite reumatoide em comparação com as medicações anteriores, analisando a redução da morbidade e mortalidade dos pacientes acometidos. A presente revisão tratará de uma revisão narrativa da literatura a respeito da Artrite reumatoide, abrangendo seu quadro clínico, epidemiologia, bem como a diferença entre os tratamentos anteriormente empregados e o uso dos inibidores de Janus Kinases.

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Published

2021-05-03

How to Cite

VIEIRA, G. M.; PIVA, D. O.; PIO, G. P.; DAMASCENO, R. L.; JAPIASSU, R. de V. N.; MACEDO, A. C.; JÚNIOR, L. P. Uso de Inibidores de Janus Kinase no tratamento da Artrite Reumatoide / Use of Janus Kinase Inhibitors in the treatment of Rheumatoid Arthritis. Brazilian Journal of Health Review, [S. l.], v. 4, n. 3, p. 9701–9718, 2021. DOI: 10.34119/bjhrv4n3-009. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/29153. Acesso em: 29 mar. 2024.

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Section

Original Papers