Nutritional Interventions In The Treatment Of Acne Vulgaris: A Systematic Review Of Clinical Trials / Intervenções Nutricionais No Tratamento Da Acne Vulgaris: Uma Revisão Sistemática Dos Ensaios Clínicos

Felipe de Souza Cardoso, Patricia Coelho de Velasco, Fátima Lúcia de Carvalho Sardinha, Karla Yasmin Dias Fraga, Ana Maria Mósca de Cerqueira, Andréa Carla Silva da Costa, Maria das Graças Tavares do Carmo

Abstract


The aim of this study is to review the literature about dietary interventions on acne vulgaris in order to support the development of more effective treatments in clinical practice. A systematic review of the literature, from clinical trials over the last five years, available in Pub Med and SciELO. The selected articles were analyzed according to the Jadad scale, CONSORT and risk of bias using the Cochrane protocol. CONSORT indicated that most of the evidence score was attributed in the titles, abstracts and some of the methods. In particular, the methods of the studies evaluated, when lacking detail, received lower scores, among the evidence, expressed as a percentage. The results, after using the Jadad scale, indicated a similar profile to that obtained with the CONSORT protocol. However, this tool is limited with regard to randomization and blinding. Using the Cochrane method, the risk of bias was evaluated. Results corroborated the evaluations by CONSORT and Jadad scale. Supplementation with n-3 fatty acids, Camellia sinensis, Berberis vulgaris, chromium, selenium and probiotics were significant, but results were limited for the treatment of acne vulgaris. Consumption of foods with increased glycemic load and chocolate indicated a correlation with an increase in acneiform lesions. Changes in nutritional status of alfa-tocopherol, cobalamin and folic acid were associated with the use of isotretinoin. There is a need to increase the quantity and quality of scientific evidence on the nutritional treatment of acne vulgaris in order to more effectively and safely guide the nutritional actions of clinical practice today.


Keywords


acne vulgaris, nutritional supplementation, bioactive compounds, inflammation, dermatology

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References


Costa A, Alchorne MMA, Goldschmidt MCB (2008) Fatores etiopatogênicos da acne. An Bras Dermatol 83, 451-9.

Ribas J, Oliveira CMPB (2008) Acne vulgaris and well-being in medical students. An. Bras. Dermatol 83, 520-5.

Meneses Z, Bouzas I (2009) Acne vulgaris and adolescence. Adolescência & Saúde 6, 21-3.

Figueiredo A, Massa A, Picoto A et al. (2011) Avaliação e tratamento do doente com acne – Parte I: Epidemiologia, etiopatogenia, clínica, classificação, impacto psicossocial, mitos e realidades, diagnóstico diferencial e estudos complementares. Rev Port Clin Geral 7, 59-65.

Antoniou C, Dessinioti C, Sotiriadis D et al. (2016) A multicenter, randomized, split-face clinical trial evaluating the efficacy and safety of chromophore gel-assisted blue light phototherapy for the treatment of acne. Int J Dermatol 55, 1321-8.

Kurokawa I, Danby FW, Ju Q et al. (2009) New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 18, 821-32.

Reuter J, Merfort I, Schempp CM (2010) Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol 11, 247-67.

Bowe WP, Logan AC (2011) Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future? Gut Pathog 31, 1.

Goforoushan F, Azimi H, Goldust M (2013) Efficacy of Vitamin E to Prevent Dermal Complications of Isotretinoin. Pak J Biol Sci 16, 548-50.

Gökalp H, Bulur I, Gürer M (2014) Decreased vitamin B12 and folic Acid concentrations in acne patients after isotretinoin therapy: a controlled study. Indian J Dermatol 59, 630.

Kang D, Shi B, Erfe MC et al. (2015) Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. Sci Transl Med 24, 293ra103.

Jadad AR, Moore RA, Carroll D et al. (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17, 1-12.

Schulz KF, Altman DG, Moher D, for the CONSORT Group (2010) CONSORT 2010 Statement: updated guidelines for reporting parallel group randomized trials. Ann Int Med 152.

De Carvalho AP, Silva V, Grande J. Avaliação do risco de viés de ensaios clínicos randomizados pela ferramenta da colaboração Cochrane. Diagn Tratamento. 2013;18(1):38-44.

Fouladi RF (2012) Aqueous extract of dried fruit of Berberis vulgaris L. in acne vulgaris, a clinical trial. J Diet Suppl 9, 253-61.

Razavi M, Jamilian M, Kashan ZF et al. (2016) Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome. Horm Metab Res 48, 185-90.

Lu PH, Hsu CH (2016) Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial. Complement Ther Med 25, 159-63.

Kim K, Kim K-II, Lee J (2016) Inhibitory effects of Cheongsangbangpoong-tang on both inflammatory acne lesions and facial heat in patients with acne vulgaris: A randomized controlled trial protocol. BMC Complement Altern Med 22, 21.

Jung JY, Kwon HH, Hong JS et al. (2014) Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta Derm Venereol 94, 521-5.

Jung GW, Tse JE, Guiha I et al. (2013) Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg 17, 114-22.

Delost GR, Delost ME, Lloyd J (2016) The impact of chocolate consumption on acne vulgaris in college students: A randomized crossover study. J Am Acad Dermatol 75, 220-222.

Goforoushan F, Azimi H, Goldust M (2013) Efficacy of Vitamin E to Prevent Dermal Complications of Isotretinoin. Pak J Biol Sci 16, 548-550.

Forest JM, Rafikhah N (2014) Oral Aqueous Green Tea Extract and Acne Vulgaris: A Placebo-Controlled Study. Asia J Clin Nutr 6, 41-46.

Jamilian M, Bahmani F, Siavashani MA et al. (2016) The Effects of Chromium Supplementation on Endocrine Profiles, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biol Trace Elem Res 172, 72-78.

Shalita AR, Falcon R, Olansky A et al. (2012) Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol 11, 1428-1433.

Fabbrocini G, Izzo R, Faggiano A et al. (2016) Low glycaemic diet and metformin therapy: a new approach in male subjects with acne resistant to common treatments. Clin Exp Dermatol 41, 38-42.

Formuso C, Stracquadanio M, Ciotta L (2015) Myo-inositol vs. D-chiro inositol in PCOS treatment. Minerva Ginecol 67, 321-325.

Goforoushan F, Azimi H, Goldust M (2013) Efficacy of Vitamin E to Prevent Dermal Complications of Isotretinoin. Pak J Biol Sci 16, 548-550.

Fabbrocini G, De Vita V, Monfrecola A et al. (2014) Percutaneous collagen induction: an effective and safe treatment for post-acne scarring in different skin phototypes. J Dermatolog Treat 25, 147-152.

Kamal M, Polat M (2015) Effect of different doses of isotretinoin treatment on the levels of serum homocysteine, vitamin B 12 and folic acid in patients with acne vulgaris: A prospective controlled study. J Pak Med Assoc 65, 950-953.

Javanbakht AM, Pour HM, Tarrahic MJ (2012) Effects of oral isotretinoin on serum folic acid levels. J Drugs Dermatol 11, e23-24.

Aktürk AŞ, Güzel S, Bulca S et al. (2013) Effects of isotretinoin on serum vitamin E levels in patients with acne. Int J Dermatol 52, 363-366.




DOI: https://doi.org/10.34119/bjhrv4n2-295

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