Efeito da Aplicação da energia vermelha monocromática (MIRE®) sobre a cicatrização de feridas cutâneas em ratos diabéticos / Monochromatic infrared energy application effect (MIRE®) of skin healing wounds in diabetic rats

Felipe Scipião Moura, Francisco Valmor Macedo Cunha, Leonel Marques Rodrigues, Amanda Mota da Silva, Ana Marcelina Scipião Moura, Oséas Florêncio de Moura Filho, Maria do Carmo de Carvalho e Martins

Abstract


Introduction: The monochromatic infrared energy use (MIRE®) as a resource to promote healing shows excellent prospects. Objective:  Determine the MIRE (890nm) application effect  in skin wounds healing in diabetic rats. Methods: Experimental type study, with qualitative and quantitative sample data  evaluation. Skin wounds 1 cm2  were made in the dorsal region Rattus norvegicus diabetics, who were randomly distributed in 14 animals  groups  and treated for seven to 14 days with 0.9% saline (control group - C) phototherapy (MIRE - wavelength = 890 nm; energy density = 24,96J / cm2; and irradiation time = 600 seconds) or clostebol acetate / neomycin sulfate (Trofodermin® - Default). Comparisons between groups were performed by ANOVA followed by post-Newman-Keuls test. Results: No statistically significant differences were found between the groups in the wounds contraction on the 4th day after wounds production. There was significantly higher wound contraction (p <0.05) in  standard group (0.66 ± 0.02) compared to MIRE® (0.27 ± 0.03) and control (0.43 ± 0, 07) on the 7th monitoring day. On  14th  treatment day, the wound contraction was higher (p <0.05) in standard group (0.87 ± 0.04) and MIRE® (0.81 ± 0.04) compared with control (0 68 ± 0.06). A semi-quantitative histological analysis revealed increased vascular proliferation in MIRE®. Conclusion: The results indicate that treatment with MIRE® favored the open wounds  healing in diabetic rats.


Keywords


Phototherapy, Wound Healing, Diabetes Mellitus

References


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DOI: https://doi.org/10.34119/bjhrv4n2-147

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