HIV-1 Subtipo F no Brasil: Características moleculares, patogênese, importância na dispersão da epidemia e geração dos recombinantes BF do vírus / HIV-1 Subtype F in Brazil: Molecular characteristics, pathogenesis, importance in the spread of the epidemic and generation of BF recombinants of the vírus

Authors

  • Edson Barbosa de Souza Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Aldenize Pimentel de Souza
  • Icaro Pedro do Nascimento
  • Nicácio de Oliveira Freitas
  • Caio Augusto Martins Aires
  • Kledoaldo Lima

DOI:

https://doi.org/10.34119/bjhrv4n2-122

Keywords:

HIV-1, epidemiologia molecular, resistência antirretroviral, subtipos.

Abstract

 

Introdução: O presente estudo objetivou avaliar o papel do HIV-1 subtipo F na epidemia de Aids no Brasil, na patogênese da doença e origem dos recombinantes BF. Métodos: Realizou-se uma pesquisa bibliográfica nos bancos de dados do Pubmed e Scielo, com a finalidade de avaliar os artigos relacionados com a epidemiologia molecular do HIV-1 subtipo F no país. Revisão bibliográfica: A primeira identificação do subtipo F, no Brasil, aconteceu em quatro amostras coletadas entre 1989-1990, entretanto, o primeiro estudo sobre a história evolucionária desse subtipo estimou que o início desta epidemia ocorreu no início da década de 1980. Alguns estudos relacionam a presença do subtipo F com a transmissão heterossexual e na demonstração que o mesmo possuía mais mutações relacionadas à alguns antirretrovirais, como para Inibidores de Protease (IPs). Além disso, outros trabalhos relacionam a presença deste subtipo a alguns grupos epidemiológicos e à menor carga viral e maior contagem de células T CD4+. Conclusão: Assim, revela-se a importância da epidemiologia e caracterização molecular destas variantes para um melhor entendimento da sua dinâmica na epidemia brasileira do HIV-1 e na ampliação do conhecimento quanto às suas peculiaridades genéticas que podem interferir nas suas patogêneses, transmissões, respostas à terapia antirretroviral e a vacinas.  

 

 

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Published

2021-03-15

How to Cite

DE SOUZA, E. B.; DE SOUZA, A. P.; DO NASCIMENTO, I. P.; FREITAS, N. de O.; AIRES, C. A. M.; LIMA, K. HIV-1 Subtipo F no Brasil: Características moleculares, patogênese, importância na dispersão da epidemia e geração dos recombinantes BF do vírus / HIV-1 Subtype F in Brazil: Molecular characteristics, pathogenesis, importance in the spread of the epidemic and generation of BF recombinants of the vírus. Brazilian Journal of Health Review, [S. l.], v. 4, n. 2, p. 5530–5545, 2021. DOI: 10.34119/bjhrv4n2-122. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26388. Acesso em: 28 mar. 2024.

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Section

Original Papers