HIV-1 Subtipo F no Brasil: Características moleculares, patogênese, importância na dispersão da epidemia e geração dos recombinantes BF do vírus / HIV-1 Subtype F in Brazil: Molecular characteristics, pathogenesis, importance in the spread of the epidemic and generation of BF recombinants of the vírus

Edson Barbosa de Souza, Aldenize Pimentel de Souza, Icaro Pedro do Nascimento, Nicácio de Oliveira Freitas, Caio Augusto Martins Aires, Kledoaldo Lima

Abstract


 

Introdução: O presente estudo objetivou avaliar o papel do HIV-1 subtipo F na epidemia de Aids no Brasil, na patogênese da doença e origem dos recombinantes BF. Métodos: Realizou-se uma pesquisa bibliográfica nos bancos de dados do Pubmed e Scielo, com a finalidade de avaliar os artigos relacionados com a epidemiologia molecular do HIV-1 subtipo F no país. Revisão bibliográfica: A primeira identificação do subtipo F, no Brasil, aconteceu em quatro amostras coletadas entre 1989-1990, entretanto, o primeiro estudo sobre a história evolucionária desse subtipo estimou que o início desta epidemia ocorreu no início da década de 1980. Alguns estudos relacionam a presença do subtipo F com a transmissão heterossexual e na demonstração que o mesmo possuía mais mutações relacionadas à alguns antirretrovirais, como para Inibidores de Protease (IPs). Além disso, outros trabalhos relacionam a presença deste subtipo a alguns grupos epidemiológicos e à menor carga viral e maior contagem de células T CD4+. Conclusão: Assim, revela-se a importância da epidemiologia e caracterização molecular destas variantes para um melhor entendimento da sua dinâmica na epidemia brasileira do HIV-1 e na ampliação do conhecimento quanto às suas peculiaridades genéticas que podem interferir nas suas patogêneses, transmissões, respostas à terapia antirretroviral e a vacinas.  

 

 


Keywords


HIV-1, epidemiologia molecular, resistência antirretroviral, subtipos.

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DOI: https://doi.org/10.34119/bjhrv4n2-122

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