Terapias imunossupressoras no tratamento de COVID-19: uma revisão integrativa da literatura / Immunosuppressive therapies treatments for COVID-19: a literature review

Authors

  • Ana Beatriz Souza Machado
  • Amanda Fonseca Alves
  • Hállefy Ribeiro Araújo
  • Jhenifer Ferreira Barros
  • Luana Sertão Felipe Teixeira
  • Rodrigo Scaliante de Moura

DOI:

https://doi.org/10.34119/bjhrv4n2-087

Keywords:

Infecções por Coronavirus, Fatores Imunológicos, Síndrome Respiratória Aguda Grave, Pandemias.

Abstract

O atual cenário pandêmico, provocado pelo SARS-CoV-2, propiciou uma busca por tratamentos para combater a COVID-19. Como o avanço da doença está relacionado com um quadro inflamatório grave, grande parte dos medicamentos em estudo estão relacionados direta ou indiretamente com mecanismos de imunossupressão. O objetivo dessa revisão integrativa da literatura foi descrever as alternativas imunossupressoras para a COVID-19. A busca foi realizada nos bancos de dados do PubMed e LILACS por estudos que abrangiam ensaios clínicos relacionados a terapias imunossupressoras primárias ou secundárias e sua efetividade no combate ao Coronavírus. À vista disso, os tratamentos de ação primária mostraram-se promissores quanto a redução do tempo de internação, uso de ventilação mecânica e minimização dos efeitos da cascata de inflamação gerados pela COVID-19. Contudo, a mortalidade hospitalar foi mais pronunciada em pacientes graves que estavam em uso de corticosteroides do que aqueles que não fizeram uso da medicação. Outrossim, o uso das drogas de ação secundária mostrou-se pouco eficaz no combate ao vírus. Por fim, diante das análises apresentadas neste trabalho, conclui-se que a ação imunossupressora dos tratamentos estudados possuem caráter animador no combate a COVID-19.

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Published

2021-03-11

How to Cite

MACHADO, A. B. S.; ALVES, A. F.; ARAÚJO, H. R.; BARROS, J. F.; TEIXEIRA, L. S. F.; MOURA, R. S. de. Terapias imunossupressoras no tratamento de COVID-19: uma revisão integrativa da literatura / Immunosuppressive therapies treatments for COVID-19: a literature review. Brazilian Journal of Health Review, [S. l.], v. 4, n. 2, p. 5115–5130, 2021. DOI: 10.34119/bjhrv4n2-087. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/26120. Acesso em: 28 mar. 2024.

Issue

Section

Original Papers