A importância do monitoramento do SARS-CoV-2 em redes de esgoto e estações de tratamento de águas residuárias / The importance of monitoring the SARS-CoV-2 in sewage networks and wastewater treatment plants

Pedro Henrique Mainardi, Ederio Dino Bidoia

Abstract


 

 

O SARS-CoV-2, um novo tipo de coronavírus capaz de infectar humanos e causar a síndrome respiratória aguda grave COVID-19, tem causado enormes impactos em toda a Terra. A doença, devido ao seu alto potencial de disseminação e alto índice de fatalidade, foi decretada como pandêmica pela Organização Mundial da Saúde em março de 2020. Pacientes com COVID-19, incluindo casos leves ou assintomáticos, frequentemente foram vistos por conter em amostras de urina e fezes fragmentos infecciosos do vírus SARS-CoV-2. Dessa forma, estudos de detecção do novo coronavírus nas redes de esgoto e em estações de tratamento de águas residuárias, que coletam e concentram excretos humanos, têm sido extremamente úteis como uma ferramenta de monitoramento do vírus nas comunidades. A abordagem, comumente aplicada na elaboração de diagnósticos não-invasivos sobre a circulação de substâncias químicas e poluentes nas populações, poderia ser utilizada como um alerta rápido sobre possíveis surtos de COVID-19. Esse tipo de monitoramento propiciaria melhores previsões acerca da propagação do SARS-CoV-2, além de fomentar o desenvolvimento de melhores medidas de contenção viral, sistemas de desinfecção e avaliação da eficácia das vacinas. Nesta revisão, foram apresentados relatos de detecção do SARS-CoV-2 nas redes de esgoto e estações de tratamento de águas residuárias, e abordado a importância do monitoramento do novo coronavírus nesse ambiente.

 

 


Keywords


Epidemiologia, Monitoramento epidemiológico, Saúde pública, Medicina preventiva, Vigilância epidemiológica, Saúde coletiv

References


DA SILVA MARTIN, P.; GONÇALVES, S. L.; DO SANTOS GOULARTE, P.; DIAS, E. P.; LEONARDI, A. E.; TIEZZI, D. G.; GABRIEL, S. A.; CHIN, C. M. História e Epidemiologia da COVID-19. Revista Ulakes, v. 1, 2020.

ANDERSEN, K. G.; RAMBAUT, A.; LIPKIN, W. I.; HOLMES, E. C.; GARRY, R. F. The proximal origin of SARS-CoV-2. Nature Medicine, v. 26, n. 4, p. 450–452, abr. 2020.

LANA, R. M.; COELHO, F. C.; GOMES, M. F. da C.; CRUZ, O. G.; BASTOS, L. S.; VILLELA, D. A. M.; CODEÇO, C. T. Emergência do novo coronavírus (SARS-CoV-2) e o papel de uma vigilância nacional em saúde oportuna e efetiva. Cadernos de Saúde Pública, v. 36, n. 3, p. e00019620, 2020.

GRUNIG, G.; DURMUS, N.; MARSH, L. New Coronavirus (COVID-19) Pandemic: Complexities Resulting in a Tragedy. preprint. [S. l.]: LIFE SCIENCES, 26 abr. 2020.

WU, D.; WU, T.; LIU, Q.; YANG, Z. The SARS-CoV-2 outbreak: What we know. International Journal of Infectious Diseases, v. 94, p. 44–48, maio 2020a.

ORGANIZAÇÃO MUNDIAL DA SAÚDE. WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020. Genebra: OMS, 2020a.

TEIXEIRA, C. M. do E.; MADRUGA, G. de A. M.; MEDEIROS, G. B. dos S.; LEITE FILHO, J. G. T. de M.; DUARTE, S. S. de M. Análise das manifestações sistêmicas do SARS-CoV-2. Brazilian Journal of Health Review, v. 3, n. 2, p. 3212–3217, 2020.

ORGANIZAÇÃO MUNDIAL DA SAÚDE. WHO Coronavirus Disease (COVID-19) Dashboard. OMS, 2020b. https://covid19.who.int/.

SUN, P.; QIE, S.; LIU, Z.; REN, J.; LI, K.; XI, J. Clinical characteristics of hospitalized patients with SARS‐CoV‐2 infection: A single arm meta‐analysis. Journal of Medical Virology, v. 92, n. 6, p. 612–617, jun. 2020.

XU, X.-W.; WU, X.-X.; JIANG, X.-G.; XU, K.-J.; YING, L.-J.; MA, C.-L.; LI, S.-B.; WANG, H.-Y.; ZHANG, S.; GAO, H.-N.; SHENG, J.-F.; CAI, H.-L.; QIU, Y.-Q.; LI, L.-J. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ, v. 368, 19 fev. 2020.

DIAO, B.; WANG, C.; WANG, R.; FENG, Z.; TAN, Y.; WANG, H.; WANG, C.; LIU, L.; LIU, Y.; LIU, Y.; WANG, G.; YUAN, Z.; REN, L.; WU, Y.; CHEN, Y. Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 6 mar. 2020.

HONG, N.; YU, W.; XIA, J.; SHEN, Y.; YAP, M.; HAN, W. Evaluation of ocular symptoms and tropism of SARS‐CoV‐2 in patients confirmed with COVID‐19. Acta Ophthalmologica, v. 98, n. 5, ago. 2020.

LIN, L.; JIANG, X.; ZHANG, Z.; HUANG, S.; ZHANG, Z.; FANG, Z.; GU, Z.; GAO, L.; SHI, H.; MAI, L.; LIU, Y.; LIN, X.; LAI, R.; YAN, Z.; LI, X.; SHAN, H. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut, v. 69, n. 6, p. 997–1001, jun. 2020.

PONTELLI, M. C.; CASTRO, I. A.; MARTINS, R. B.; VERAS, F. P.; SERRA, L. L.; NASCIMENTO, D. C.; CARDOSO, R. S.; ROSALES, R.; LIMA, T. M.; SOUZA, J. P.; CAETITÉ, D. B.; DE LIMA, M. H. F.; KAWAHISA, J. T.; GIANNINI, M. C.; BONJORNO, L. P.; LOPES, M. I. F.; BATAH, S. S.; SIYUAN, L.; ASSAD, R. L.; … ARRUDA, E. Infection of human lymphomononuclear cells by SARS-CoV-2. preprint. [S. l.]: Microbiology, 29 jul. 2020.

WANG, H.-Y.; LI, X.-L.; YAN, Z.-R.; SUN, X.-P.; HAN, J.; ZHANG, B.-W. Potential neurological symptoms of COVID-19. Therapeutic Advances in Neurological Disorders, v. 13, p. 175628642091783, jan. 2020a.

ZHENG, Y.-Y.; MA, Y.-T.; ZHANG, J.-Y.; XIE, X. COVID-19 and the cardiovascular system. Nature Reviews Cardiology, v. 17, n. 5, p. 259–260, maio 2020.

ENYOH, C. E.; WIRNKOR VERLA, A.; QINGYUE, W.; KUMAR YADAV, D.; AKHTER HOSSAIN CHOWDHURY, M.; OBINNA ISIUKU, B.; CHOWDHURY, T.; CHIZORUO IBE, F.; NGOZI VERLA, E.; OLUWATOSIN MADUKA, T. Indirect exposure to novel coronavirus (SARS-CoV-2): an overview of current knowledge. Jurnal Teknologi Laboratorium, v. 9, n. 1, p. 67–77, 23 jul. 2020.

MESELSON, M. Droplets and Aerosols in the Transmission of SARS-CoV-2. New England Journal of Medicine, v. 382, n. 21, p. 2063–2063, 21 maio 2020.

MORAWSKA, L.; CAO, J. Airborne transmission of SARS-CoV-2: The world should face the reality. Environment International, v. 139, p. 105730, jun. 2020.

CHU, D. K.; AKL, E. A.; DUDA, S.; SOLO, K.; YAACOUB, S.; SCHÜNEMANN, H. J.; CHU, D. K.; AKL, E. A.; EL-HARAKEH, A.; BOGNANNI, A.; LOTFI, T.; LOEB, M.; HAJIZADEH, A.; BAK, A.; IZCOVICH, A.; CUELLO-GARCIA, C. A.; CHEN, C.; HARRIS, D. J.; BOROWIACK, E.; … SCHÜNEMANN, H. J. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. The Lancet, v. 395, n. 10242, p. 1973–1987, jun. 2020.

DING, Z.; QIAN, H.; XU, B.; HUANG, Y.; MIAO, T.; YEN, H.-L.; XIAO, S.; CUI, L.; WU, X.; SHAO, W.; SONG, Y.; SHA, L.; ZHOU, L.; XU, Y.; ZHU, B.; LI, Y. Toilets dominate environmental detection of severe acute respiratory syndrome coronavirus 2 in a hospital. Science of The Total Environment, v. 753, p. 141710, jan. 2021.

FATHIZADEH, H.; MAROUFI, P.; MOMEN-HERAVI, M.; DAO, S.; KÖSE, S.; GANBAROV, K.; PAGLIANO, P.; ESPOSITO, S.; KAFIL, H. S. Protection and disinfection policies against SARS-CoV-2 (COVID-19). Infez Med, v. 28, n. 2, p. 185-91, 2020.

MOUCHTOURI, V. A.; KOUREAS, M.; KYRITSI, M.; VONTAS, A.; KOURENTIS, L.; SAPOUNAS, S.; RIGAKOS, G.; PETINAKI, E.; TSIODRAS, S.; HADJICHRISTODOULOU, C. Environmental contamination of SARS-CoV-2 on surfaces, air-conditioner and ventilation systems. International Journal of Hygiene and Environmental Health, v. 230, p. 113599, set. 2020.

ORGANIZAÇÃO MUNDIAL DA SAÚDE. Water, sanitation, hygiene, and waste management for SARS-CoV-2, the virus that causes COVID-19: interim guidance, 29 July 2020. OMS, 2020c.

JIANG, X.; LUO, M.; ZOU, Z.; WANG, X.; CHEN, C.; QIU, J. Asymptomatic SARS‐CoV‐2 infected case with viral detection positive in stool but negative in nasopharyngeal samples lasts for 42 days. Journal of Medical Virology, v. 92, n. 10, p. 1807–1809, out. 2020.

KIM, J.-M.; KIM, H. M.; LEE, E. J.; JO, H. J.; YOON, Y.; LEE, N.-J.; SON, J.; LEE, Y.-J.; KIM, M. S.; LEE, Y.-P.; CHAE, S.-J.; PARK, K. R.; CHO, S.-R.; PARK, S.; KIM, S. J.; WANG, E.; WOO, S.; LIM, A.; PARK, S.-J.; … YOO, C. K. Detection and Isolation of SARS-CoV-2 in Serum, Urine, and Stool Specimens of COVID-19 Patients from the Republic of Korea. Osong Public Health and Research Perspectives, v. 11, n. 3, p. 112–117, 30 jun. 2020.

PARK, S.; LEE, C.-W.; PARK, D.-I.; WOO, H.-Y.; CHEONG, H. S.; SHIN, H. C.; AHN, K.; KWON, M.-J.; JOO, E.-J. Detection of SARS-CoV-2 in Fecal Samples From Patients With Asymptomatic and Mild COVID-19 in Korea. Clinical Gastroenterology and Hepatology, p. S1542356520307771, jun. 2020.

PENG, L.; LIU, J.; XU, W.; LUO, Q.; CHEN, D.; LEI, Z.; HUANG, Z.; LI, X.; DENG, K.; LIN, B.; GAO, Z. SARS‐CoV‐2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens. Journal of Medical Virology, v. 92, n. 9, p. 1676–1680, set. 2020.

TANG, A.; TONG, Z.; WANG, H.; DAI, Y.; LI, K.; LIU, J.; WU, W.; YUAN, C.; YU, M.; LI, P.; YAN, J. Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China. Emerging Infectious Diseases, v. 26, n. 6, p. 1337–1339, jun. 2020.

BRÖNIMANN, S.; REBHAN, K.; LEMBERGER, U.; MISRAI, V.; SHARIAT, S. F.; PRADERE, B. Secretion of severe acute respiratory syndrome coronavirus 2 in urine. Current Opinion in Urology, v. Publish Ahead of Print, 20 jul. 2020.

QIAN, Q.; FAN, L.; LIU, W.; LI, J.; YUE, J.; WANG, M.; KE, X.; YIN, Y.; CHEN, Q.; JIANG, C. Direct evidence of active SARS-CoV-2 replication in the intestine. Clinical Infectious Diseases, p. ciaa925, 8 jul. 2020.

WU, Y.; GUO, C.; TANG, L.; HONG, Z.; ZHOU, J.; DONG, X.; YIN, H.; XIAO, Q.; TANG, Y.; QU, X.; KUANG, L.; FANG, X.; MISHRA, N.; LU, J.; SHAN, H.; JIANG, G.; HUANG, X. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The Lancet Gastroenterology & Hepatology, v. 5, n. 5, p. 434–435, maio 2020b.

JEONG, H. W.; KIM, S.-M.; KIM, H.-S.; KIM, Y.-I.; KIM, J. H.; CHO, J. Y.; KIM, S.; KANG, H.; KIM, S.-G.; PARK, S.-J.; KIM, E.-H.; CHOI, Y. K. Viable SARS-CoV-2 in various specimens from COVID-19 patients. Clinical Microbiology and Infection, p. S1198743X20304274, jul. 2020.

KANG, M.; WEI, J.; YUAN, J.; GUO, J.; ZHANG, Y.; HANG, J.; QU, Y.; QIAN, H.; ZHUANG, Y.; CHEN, X.; PENG, X.; SHI, T.; WANG, J.; WU, J.; SONG, T.; HE, J.; LI, Y.; ZHONG, N. Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building. Annals of Internal Medicine, p. M20-0928, 1 set. 2020.

KASHI, A. H.; DE LA ROSETTE, J.; AMINI, E.; ABDI, H.; FALLAH-KARKAN, M.; VAEZJALALI, M. Urinary Viral Shedding of COVID-19 and its Clinical Associations: A Systematic Review and Meta-analysis of Observational Studies. Urology Journal, n. 2019: Instant, p. 6248, 5 set. 2020.

PARASA, S.; DESAI, M.; THOGULUVA CHANDRASEKAR, V.; PATEL, H. K.; KENNEDY, K. F.; ROESCH, T.; SPADACCINI, M.; COLOMBO, M.; GABBIADINI, R.; ARTIFON, E. L. A.; REPICI, A.; SHARMA, P. Prevalence of Gastrointestinal Symptoms and Fecal Viral Shedding in Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis. JAMA Network Open, v. 3, n. 6, p. e2011335, 11 jun. 2020.

PATEL, K. P.; VUNNAM, S. R.; PATEL, P. A.; KRILL, K. L.; KORBITZ, P. M.; GALLAGHER, J. P.; SUH, J. E.; VUNNAM, R. R. Transmission of SARS-CoV-2: an update of current literature. European Journal of Clinical Microbiology & Infectious Diseases, 7 jul. 2020.

CHAVARRIA-MIRÓ, G.; ANFRUNS-ESTRADA, E.; GUIX, S.; PARAIRA, M.; GALOFRÉ, B.; SÁANCHEZ, G.; PINTÓ, R.; BOSCH, A. Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases. preprint. [S. l.]: Epidemiology, 13 jun. 2020.

FONGARO, G.; HERMES STOCO, P.; SOBRAL MARQUES SOUZA, D.; GRISARD, E. C.; MAGRI, M. E.; ROGOVSKI, P.; SCHORNER, M. A.; HARTMANN BARAZZETTI, F.; CHRISTOFF, A. P.; DE OLIVEIRA, L. F. V.; BAZZO, M. L.; WAGNER, G.; HERNANDEZ, M.; RODRIGUEZ-LAZARO, D. SARS-CoV-2 in human sewage in Santa Catalina, Brazil, November 2019. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 29 jun. 2020.

LA ROSA, G.; MANCINI, P.; BONANNO FERRARO, G.; VENERI, C.; IACONELLI, M.; BONADONNA, L.; LUCENTINI, L.; SUFFREDINI, E. SARS-CoV-2 has been circulating in northern Italy since December 2019: evidence from environmental monitoring. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 26 jun. 2020.

TIAN, H.; LIU, Y.; LI, Y.; WU, C.-H.; CHEN, B.; KRAEMER, M. U. G.; LI, B.; CAI, J.; XU, B.; YANG, Q.; WANG, B.; YANG, P.; CUI, Y.; SONG, Y.; ZHENG, P.; WANG, Q.; BJORNSTAD, O. N.; YANG, R.; GRENFELL, B. T.; … DYE, C. An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China. Science, v. 368, n. 6491, p. 638–642, 8 maio 2020.

NIKOLAENKO, D. SARS-CoV-2 and the water environment: discovery of the pathogen in the sample dated March 12, 2019 in Barcelona and its interpretation, 2020.

BIRTOLO, L. I.; MAESTRINI, V.; SEVERINO, P.; CHIMENTI, C.; AGNES, G.; TOCCI, M.; COLAIACOMO, M. C.; FRANCONE, M.; MANCONE, M.; FEDELE, F. Coronavirus disease 2019 in Rome: was it circulating before December? Journal of Cardiovascular Medicine, v. 21, n. 10, p. 835–836, out. 2020.

DESLANDES, A.; BERTI, V.; TANDJAOUI-LAMBOTTE, Y.; ALLOUI, C.; CARBONNELLE, E.; ZAHAR, J. R.; BRICHLER, S.; COHEN, Y. SARS-CoV-2 was already spreading in France in late December 2019. International Journal of Antimicrobial Agents, v. 55, n. 6, p. 106006, jun. 2020.

GERBAUD, L.; GUIGUET-AUCLAIR, C.; BREYSSE, F.; ODOUL, J.; OUCHCHANE, L.; PETERSCHMITT, J.; DEZFOULI-DESFER, C.; BRETON, V. Hospital and Population-Based Evidences for COVID-19 Early Circulation in the East of France. preprint. [S. l.]: MEDICINE & PHARMACOLOGY, 8 ago. 2020.

PAOLO, C.; CARMELO, S.; MARCELLO, M. Ageusia, gastrointestinal symptoms and marked asthenia in late December. A single case report with positive SARS-Cov2 IgG in Italy. International Journal of Infectious Diseases, v. 97, p. 352–353, ago. 2020.

VALENTI, L.; BERGNA, A.; PELUSI, S.; FACCIOTTI, F.; LAI, A.; TARKOWSKI, M.; BERZUINI, A.; CAPRIOLI, F.; SANTORO, L.; BASELLI, G.; DELLA VENTURA, C.; ERBA, E.; BOSARI, S.; GALLI, M.; ZEHENDER, G.; PRATI, D. SARS-CoV-2 seroprevalence trends in healthy blood donors during the COVID-19 Milan outbreak. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 18 maio 2020.

AHMED, W.; ANGEL, N.; EDSON, J.; BIBBY, K.; BIVINS, A.; O’BRIEN, J. W.; CHOI, P. M.; KITAJIMA, M.; SIMPSON, S. L.; LI, J.; TSCHARKE, B.; VERHAGEN, R.; SMITH, W. J. M.; ZAUGG, J.; DIERENS, L.; HUGENHOLTZ, P.; THOMAS, K. V.; MUELLER, J. F. First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the community. Science of The Total Environment, v. 728, p. 138764, ago. 2020.

GONZALEZ, R.; CURTIS, K.; BIVINS, A.; BIBBY, K.; WEIR, M. H.; YETKA, K.; THOMPSON, H.; KEELING, D.; MITCHELL, J.; GONZALEZ, D. COVID-19 surveillance in Southeastern Virginia using wastewater-based epidemiology. Water Research, v. 186, p. 116296, nov. 2020.

MEDEMA, G.; HEIJNEN, L.; ELSINGA, G.; ITALIAANDER, R.; BROUWER, A. Presence of SARS-Coronavirus-2 in sewage. preprint. [S. l.]: Occupational and Environmental Health, 30 mar. 2020.

RANDAZZO, W.; TRUCHADO, P.; FERRANDO, E. C.; SIMON, P.; ALLENDE, A.; SANCHEZ, G. SARS-CoV-2 RNA titers in wastewater anticipated COVID-19 occurrence in a low prevalence area. preprint. [S. l.]: Occupational and Environmental Health, 25 abr. 2020.

SHARIF, S.; IKRAM, A.; KHURSHID, A.; SALMAN, M.; MEHMOOD, N.; ARSHAD, Y.; AHMAD, J.; ANGEZ, M.; ALAM, M. M.; REHMAN, L.; MUJTABA, G.; HUSSAIN, J.; ALI, J.; AKTHAR, Ri.; MALIK, M. W.; BAIG, Z. I.; RANA, M. S.; USMAN, M.; ALI, M. Q.; … ALI, N. Detection of SARS-Coronavirus-2 in wastewater, using the existing environmental surveillance network: An epidemiological gateway to an early warning for COVID-19 in communities. preprint. [S. l.]: Epidemiology, 5 jun. 2020.

WANG, J.; FENG, H.; ZHANG, S.; NI, Z.; NI, L.; CHEN, Y.; ZHUO, L.; ZHONG, Z.; QU, T. SARS-CoV-2 RNA detection of hospital isolation wards hygiene monitoring during the Coronavirus Disease 2019 outbreak in a Chinese hospital. International Journal of Infectious Diseases, v. 94, p. 103–106, maio 2020.

WURTZER, S.; MARECHAL, V.; MOUCHEL, J.-M.; MADAY, Y.; TEYSSOU, R.; RICHARD, E.; ALMAYRAC, J. L.; MOULIN, L. Evaluation of lockdown impact on SARS-CoV-2 dynamics through viral genome quantification in Paris wastewaters. preprint. [S. l.]: Epidemiology, 17 abr. 2020.

ALPASLAN KOCAMEMI, B.; KURT, H.; SAIT, A.; SARAC, F.; SAATCI, A. M.; PAKDEMIRLI, B. SARS-CoV-2 Detection in Istanbul Wastewater Treatment Plant Sludges. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 16 maio 2020.

AMPUERO, M.; VALENZUELA, S.; VALIENTE-ECHEVERRIA, F.; SOTO-RIFO, R.; BARRIGA, G. P.; CHNAIDERMAN, J.; ROJAS, C.; GUAJARDO-LEIVA, S.; DIEZ, B.; GAGGERO, A. SARS-CoV-2 Detection in Sewage in Santiago, Chile - Preliminary results. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 3 jul. 2020.

ARORA, S.; NAG, A.; SETHI, J.; RAJVANSHI, J.; SAXENA, S.; SHRIVASTAVA, S. K.; GUPTA, A. B. Sewage surveillance for the presence of SARS-CoV-2 genome as a useful wastewater based epidemiology (WBE) tracking tool in India. preprint. [S. l.]: Epidemiology, 20 jun. 2020.

BAR OR, I.; YANIV, K.; SHAGAN, M.; OZER, E.; ERSTER, O.; MENDELSON, E.; MANNASSE, B.; SHIRAZI, R.; KRAMARSKY-WINTER, E.; NIR, O.; ABU-ALI, H.; RONEN, Z.; RINOTT, E.; LEWIS, Y. E.; FRIEDLER, E. F.; PAITAN, Y.; BITKOVER, E.; BERCHENKO, Y.; KUSHMARO, A. Regressing SARS-CoV-2 sewage measurements onto COVID-19 burden in the population: a proof-of-concept for quantitative environmental surveillance. preprint. [S. l.]: Epidemiology, 1 maio 2020.

HATA, A.; HONDA, R.; HARA-YAMAMURA, H.; MEUCHI, Y. Detection of SARS-CoV-2 in wastewater in Japan by multiple molecular assays-implication for wastewater-based epidemiology (WBE). preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 11 jun. 2020.

MLEJNKOVA, H.; SOVOVA, K.; VASICKOVA, P.; OCENASKOVA, V.; JASIKOVA, L.; JURANOVA, E. Preliminary Study of Sars-Cov-2 Occurrence in Wastewater in the Czech Republic. International Journal of Environmental Research and Public Health, v. 17, n. 15, p. 5508, jan. 2020.

PRADO, T.; FUMIAN, T. M.; MANNARINO, C. F.; MARANHÃO, A. G.; SIQUEIRA, M. M.; MIAGOSTOVICH, M. P. Preliminary results of SARS-CoV-2 detection in sewerage system in Niterói municipality, Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, v. 115, p. e200196, 2020.

WESTHAUS, S.; WEBER, F.-A.; SCHIWY, S.; LINNEMANN, V.; BRINKMANN, M.; WIDERA, M.; GREVE, C.; JANKE, A.; HOLLERT, H.; WINTGENS, T.; CIESEK, S. Detection of SARS-CoV-2 in raw and treated wastewater in Germany – Suitability for COVID-19 surveillance and potential transmission risks. Science of The Total Environment, v. 751, p. 141750, jan. 2021.

CORPUZ, M. V. A.; BUONERBA, A.; VIGLIOTTA, G.; ZARRA, T.; BALLESTEROS, F.; CAMPIGLIA, P.; BELGIORNO, V.; KORSHIN, G.; NADDEO, V. Viruses in wastewater: occurrence, abundance and detection methods. Science of The Total Environment, v. 745, p. 140910, nov. 2020.

MACKAY, I. M.; ARDEN, K. E.; NITSCHE, A. Real-time PCR in virology. Nucleic acids research, v. 30, n. 6, p. 1292-1305, 2002.

ADINEH, M.; GHADERI, M.; MOUSAVI-NASAB, S. D. Occurrence of Salivirus in Sewage and River Water Samples in Karaj, Iran. Food and Environmental Virology, v. 11, n. 2, p. 193–197, jun. 2019.

AZHDAR, Z.; GHADERI, M.; MOUSAVI-NASAB, S. D. Optimization of RT-qPCR for Detection of Aichi Virus in Sewage and River Water Samples in Karaj, Iran. Archives of Iranian Medicine, v. 22, n. 5, p. 242–246, 01 2019.

BEYER, S.; SZEWZYK, R.; GNIRSS, R.; JOHNE, R.; SELINKA, H.-C. Detection and Characterization of Hepatitis E Virus Genotype 3 in Wastewater and Urban Surface Waters in Germany. Food and Environmental Virology, v. 12, n. 2, p. 137–147, jun. 2020.

MCCALL, C.; WU, H.; MIYANI, B.; XAGORARAKI, I. Identification of multiple potential viral diseases in a large urban center using wastewater surveillance. Water Research, v. 184, p. 116160, out. 2020.

MUIRHEAD, A.; ZHU, K.; BROWN, J.; BASU, M.; BRINTON, M. A.; COSTA, F.; HAYAT, M. J.; STAUBER, C. E. Zika Virus RNA Persistence in Sewage. Environmental Science & Technology Letters, v. 7, n. 9, p. 659–664, 8 set. 2020

CHOI, P. M.; TSCHARKE, B. J.; DONNER, E.; O’BRIEN, J. W.; GRANT, S. C.; KASERZON, S. L.; MACKIE, R.; O’MALLEY, E.; CROSBIE, N. D.; THOMAS, K. V.; MUELLER, J. F. Wastewater-based epidemiology biomarkers: Past, present and future. TrAC Trends in Analytical Chemistry, v. 105, p. 453–469, ago. 2018.

MESSINA, S. Monitoring Human Waste. Voices in Bioethics, , p. Vol 6 (2020), 12 jun. 2020.

DA SILVA FERREIRA, A. D.; PEREIRA PIMENTEL, C.; MOSCON, A.; NEVES CURTY, T.; DUTRA DE OLIVEIRA, M. SARS-CoV-2 NO ESGOTO: MÉTODOS DE DETECÇÃO E TRATAMENTO. Revista Ifes Ciência, v. 6, n. 1, p. 15–22, 13 jun. 2020.

LA ROSA, G.; IACONELLI, M.; MANCINI, P.; BONANNO FERRARO, G.; VENERI, C.; BONADONNA, L.; LUCENTINI, L.; SUFFREDINI, E. First detection of SARS-CoV-2 in untreated wastewaters in Italy. Science of The Total Environment, v. 736, p. 139652, set. 2020.

ORIVE, G.; LERTXUNDI, U.; BARCELO, D. Early SARS-CoV-2 outbreak detection by sewage-based epidemiology. Science of The Total Environment, v. 732, p. 139298, ago. 2020.

SODRÉ, F.; BRANDÃO, C.; VIZZOTTO, C.; MALDANER, a. Epidemiologia do esgoto como estratégia para monitoramento comunitário, mapeamento de focos emergentes e elaboração de sistemas de alerta rápido para COVID-19. Química Nova, 2020.

FOLADORI, P.; CUTRUPI, F.; SEGATA, N.; MANARA, S.; PINTO, F.; MALPEI, F.; BRUNI, L.; LA ROSA, G. SARS-CoV-2 from faeces to wastewater treatment: What do we know? A review. Science of The Total Environment, v. 743, p. 140444, nov. 2020.

HART, O. E.; HALDEN, R. U. Computational analysis of SARS-CoV-2/COVID-19 surveillance by wastewater-based epidemiology locally and globally: Feasibility, economy, opportunities and challenges. Science of The Total Environment, v. 730, p. 138875, ago. 2020.

SOUZA, L. P., SOARES, A. F. S., NUNES, B. C. R., COSTA, F. C. R., & DE MORAIS SILVA, L. F. Presença do novo coronavírus (SARS-CoV-2) nos esgotos sanitários: apontamentos para ações complementares de vigilância à saúde em tempos de pandemia. Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, v. 8, n. 3, p. 132–138, 27 ago. 2020.

THOMPSON, J. R.; NANCHARAIAH, Y. V.; GU, X.; LEE, W. L.; RAJAL, V. B.; HAINES, M. B.; GIRONES, R.; NG, L. C.; ALM, E. J.; WUERTZ, S. Making waves: Wastewater surveillance of SARS-CoV-2 for population-based health management. Water Research, v. 184, p. 116181, out. 2020.

BARROS‐RODRÍGUEZ, A.; MANZANERA, M. Units for vigilance of emerging diseases based on wastewater treatment plants (WWTP‐UVED). Microbial Biotechnology, , p. 1751-7915.13635, 27 jul. 2020.

KITAJIMA, M.; AHMED, W.; BIBBY, K.; CARDUCCI, A.; GERBA, C. P.; HAMILTON, K. A.; HARAMOTO, E.; ROSE, J. B. SARS-CoV-2 in wastewater: State of the knowledge and research needs. Science of The Total Environment, v. 739, p. 139076, out. 2020.

MAO, K.; ZHANG, H.; YANG, Z. Can a Paper-Based Device Trace COVID-19 Sources with Wastewater-Based Epidemiology? Environmental Science & Technology, v. 54, n. 7, p. 3733–3735, 7 abr. 2020.

DE MELO, M. C.; SANTOS, A. S.; VIEIRA, J. M. P. A NOVA CENTRALIDADE DA ÁGUA E DO SANEAMENTO PÓS COVID19. Revista Augustus, v. 25, n. 51, p. 294–315, 3 jun. 2020.

BAI, Y.; YAO, L.; WEI, T.; TIAN, F.; JIN, D.-Y.; CHEN, L.; WANG, M. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA, v. 323, n. 14, p. 1406, 14 abr. 2020.

WU, F.; XIAO, A.; ZHANG, J.; GU, X.; LEE, W. L.; KAUFFMAN, K.; HANAGE, W.; MATUS, M.; GHAELI, N.; ENDO, N.; DUVALLET, C.; MONIZ, K.; ERICKSON, T.; CHAI, P.; THOMPSON, J.; ALM, E. SARS-CoV-2 titers in wastewater are higher than expected from clinically confirmed cases. preprint. [S. l.]: Infectious Diseases (except HIV/AIDS), 7 abr. 2020c.

ZHANG, D.; LING, H.; HUANG, X.; LI, J.; LI, W.; YI, C.; ZHANG, T.; JIANG, Y.; HE, Y.; DENG, S.; ZHANG, X.; WANG, X.; LIU, Y.; LI, G.; QU, J. Potential spreading risks and disinfection challenges of medical wastewater by the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral RNA in septic tanks of Fangcang Hospital. Science of The Total Environment, v. 741, p. 140445, nov. 2020.

MAGNO, L.; ROSSI, T. A.; MENDONÇA-LIMA, F. W. de; SANTOS, C. C. dos; CAMPOS, G. B.; MARQUES, L. M.; PEREIRA, M.; PRADO, N. M. de B. L.; DOURADO, I. Desafios e propostas para ampliação da testagem e diagnóstico para COVID-19 no Brasil. Ciência & Saúde Coletiva, v. 25, n. 9, p. 3355–3364, set. 2020.

SARAIVA SOARES, A. F.; NUNES, B. C. R.; COSTA, F. C. R.; SILVA, L. F. de M.; SOUZA E SOUZA, L. P. Potencialidades da epidemiologia baseada em esgoto nas ações da Atenção Primária à Saúde em tempos de pandemia pela COVID-19. Journal of Management & Primary Health Care, v. 12, p. 1–10, 25 jul. 2020.

LIU, D.; THOMPSON, J. R.; CARDUCCI, A.; BI, X. Potential secondary transmission of SARS-CoV-2 via wastewater. Science of The Total Environment, v. 749, p. 142358, dez. 2020.

PATEL, J. Viability of SARS‐CoV‐2 in faecal bio‐aerosols. Colorectal Disease, v. 22, n. 9, p. 1022–1022, set. 2020.

ROLLEMBERG, S.; BARROS, A. N. de; LIMA, J. P. M. de. Avaliação da contaminação, sobrevivência e remoção do coronavírus em sistemas de tratamento de esgoto sanitário. Revista Tecnologia, v. 41, n. 1, 30 jun. 2020.

YANG, W.; CAI, C.; DAI, X. The potential exposure and transmission risk of SARS-CoV-2 through sludge treatment and disposal. Resources, Conservation and Recycling, v. 162, p. 105043, nov. 2020.

ZANETI, R. N.; GIRARDI, V.; SPILKI, F. R.; MENA, K.; WESTPHALEN, A. P. C.; COLARES, E. R. da C.; POZZEBON, A. G.; ETCHEPARE, R. G. QMRA of SARS-CoV-2 for workers in wastewater treatment plants. preprint. [S. l.]: Public and Global Health, 30 maio 2020.

GHERNAOUT, D.; GHERNAOUT, B. Controlling COVID-19 Pandemic through Wastewater Monitoring. OALib, v. 07, n. 05, p. 1–20, 2020.




DOI: https://doi.org/10.34119/bjhrv4n2-083

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