Ingestão alimentar e fatores associados a Etiopatogênese do Transtorno do Espectro Autista / Food intake and factors associated with Ethiopatogenesis of Autistic Spectrum Disorder

Pedro Costa Oliveira, Gustavo de Godoi Teixeira, Renato Merlone Rubio, Matheus Pereira Vieira, Desirrê Morais Dias, Alcimar de Melo Rosa, Marli do Carmo Cupertino

Abstract


Introdução: O diagnóstico do transtorno do espectro autista (TEA) tem aumentado significativamente na última década. O TEA não possui etiologia bem definida e a sintomatologia está relacionada a comprometimento no comportamento e interação social, além de distúrbios neurológicos com frequentes alterações alimentares, sugerindo intervenções nutricionais para melhora do quadro. Objetivo: Analisar a ingestão alimentar e alterações gastrointestinais, além de fatores associados a etiopatogênese do TEA em crianças. Métodos: Realizou-se estudo transversal através de questionários aplicados aos pais e profissionais que trabalham com as crianças, que recebem educação especial em um município de referência regional. Resultados: A exposição a fatores estressantes pré-natais e cólicas nos primeiros meses de vida foram relatados, respectivamente, em 89% e 100% das crianças com TEA. Em relação à ingestão alimentar, as crianças não apresentaram seletividade alimentar quanto à textura, temperatura, cor e características organolépticas dos alimentos, o que contribui para o aumento da diversidade alimentar e melhor adequação dos nutrientes. Foi observada alta aceitação para lácteos e alimentos com glúten, no entanto, isso não significou aumento da ocorrência de alterações gastrointestinais. Conclusão: Conclui-se que a ingestão alimentar e as alterações gastrointestinais de crianças com TEA desse estudo não apresentaram padrões diferentes de crianças normais. Porém fatores estressantes pré-natais e cólicas nos primeiros meses de vida são sugestivos de estarem associados ao desenvolvimento do TEA.


Keywords


pediatria, comportamento alimentar, transtorno autístico.

References


Satterstrom FK, Walters RK, Singh T, Wigdor EM, Lescai F, Demontis D, et al. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants. Nat Neurosci. 2019;1–5.

Ren M, Mokrani A, Liang H, Ji K, Xie J, Ge X, et al. Dietary Chromium Picolinate Supplementation Affects Growth, Whole-Body Composition, and Gene Expression Related to Glucose Metabolism and Lipogenesis in Juvenile Blunt Snout Bream, Megalobrama amblycephala. Biol Trace Elem Res. 2018;1–11.

Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcín C, et al. Global Prevalence of Autism and Other Pervasive Developmental Disorders. Autism Res. 2012;5(3):160–79.

Centers for Disease Control and Prevention. Prevalence of autism spectrum disorder among children aged 8 years. MMWR Surveill Summ [Internet]. 2014;63(2):1–21.

Gomes PTM, Lima LHL, Bueno MKG, Araújo LA, Souza NM. Autismo no Brasil, desafios familiares e estratégias de superação: revisão sistemática. J Pediatr. 2015;92(2):111–21.

Sanchack KE, Thomas CA. Autism spectrum disorder: Primary care principles. Am Fam Physician. 2016;94(12):972–9.

Park HR, Lee JM, Moon HE, Lee DS, Kim BN, Kim J, et al. A short review on the current understanding of autism spectrum disorders. Exp Neurobiol. 2016;25(1):1–13.

Dhillon S, Hellings JA, Butler MG. Genetics and Mitochondrial Abnormalities in Autism Spectrum Disorders:A Review. Current Genomics. 2011;(913):322–32.

Miles JH. Autism spectrum disorders-A genetics review. Genet Med. 2011;13(4):278–94.

Ghafouri-Fard S, Namvar A, Arsang-Jang S, Komaki A, Taheri M. Expression Analysis of BDNF, BACE1, and Their Natural Occurring Antisenses in Autistic Patients. J Mol Neurosci [Internet]. 2019.

Kern JK, Jones AM. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Heal - Part B Crit Rev. 2006;9(6):485–99.

Tan M, Yang T, Zhu J, Li Q, Lai X, Li Y, et al. Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders. Reprod Toxicol [Internet]. 2019.

Waligóra A, Waligóra S, Kozarska M, Damasiewicz-Bodzek A, Gorczyca P, Tyrpień-Golder K. Autism spectrum disorder (ASD) – biomarkers of oxidative stress and methylation and transsulfuration cycle. Psychiatr Pol. 2019;53(4):771–88.

Carvalho JA de, Santos CSS, Carvalho MP de, Souza. LS de. Nutrição e Autismo. Rev Científica do ITPAC. 2012;5:3–9.

Cupertino MC, Resende MB, Veloso IF, Carvalho CA, Duarte VF, Ramos GA. Transtorno do espectro autista: uma revisão sistemática sobre aspectos nutricionais e eixo intestino-cérebro Autism. ABCS Heal Sci. 2019;44(2):103–7.

Ristori MV, Quagliariello A, Reddel S, Ianiro G, Vicari S, Gasbarrini A, et al. Autism, gastrointestinal symptoms and modulation of gut microbiota by nutritional interventions. Nutrients. 2019;11(11):1–21.

Andreo Martínez P, García Martínez N, Sánchez Samper E. La microbiota intestinal y su relación con las enfermedades mentales a través del eje microbiota-intestino-cerebro. Rev Discapacidad, Clínica y Neurociencias. 2017;4(2):52–8.

Berding K, Donovan SM. Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs. Nutr Rev. 2016;74(12):723–36.

De Paula F., Silvério GB, Jorge RP, Felício PVP, Melo LA, Braga T. Transtorno do espectro autista: impacto no comportamento alimentar. Brazilian Journal of Health Review. 2020;3(3): 5509-5023

Kawicka A, Regulska-Ilow B. How nutritional status, diet and dietary supplements can affect autism. A review. Rocz Państwowego Zakładu Hig. 2013;64(1):1–12.

Konstantynowicz J, Porowski T, Zoch-Zwierz W, Wasilewska J, Kadziela-Olech H, Kulak W, et al. A potential pathogenic role of oxalate in autism. Eur J Paediatr Neurol. 2012;16(5):485–91.

Muniz LC, Madruga SW, Araújo CL. Consumo de leite e derivados entre adultos e idosos no Sul do Brasil: Um estudo de base populacional. Cienc e Saude Coletiva. 2013;18(12):3515–22.

White JF. Intestinal pathophysiology in autism. Exp Biol Med. 2003;228(6):639–49.

Millward C, Ferriter M, Calver SJ, Connell-Jones GG. Withdrawn: Gluten- and casein-free diets for autistic spectrum disorder. Cochrane database Syst Rev. 2019;4(1):CD003498.

Knivsberg AM, Reichelt KL, Høien T, Nødland M. Effect of a Dietary Intervention on Autistic Behavior. Focus Autism Other Dev Disabl. 2003;18(4):248–57.

Berlanga RB. Intervención nutricional en niños con autismo [thesis]. Murcia: Universidad Católica San Antonio; 2007.

Ly V, Bottelier M, Hoekstra PJ, Arias Vasquez A, Buitelaar JK, Rommelse NN. Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry. 2017;26(9):1067–79.

Panjwani AA, Ji Y, Fahey JW, Palmer A, Wang G, Hong X, et al. Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference. J Autism Dev Disord. 2019.

El-Ansary A, Chirumbolo S, Bhat RS, Dadar M, Ibrahim EM, Bjørklund G. The Role of Lipidomics in Autism Spectrum Disorder. Mol Diagnosis Ther. 2019;(0123456789).

Queiroz-Monici KDS, Costa GEA, Da Silva N, Reis SMPM, De Oliveira AC. Bifidogenic effect of dietary fiber and resistant starch from leguminous on the intestinal microbiota of rats. Nutrition. 2005;21(5):602–8.

Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, et al. Loss of predominant shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission. J Neurosci. 2013;33(47):18448–68.

Ferguson BJ, Dovgan K, Severns D, Martin S, Marler S, Gross Margolis K, et al. Lack of Associations Between Dietary Intake and Gastrointestinal Symptoms in Autism Spectrum Disorder. Front Psychiatry. 2019;10(July):1–6.

Gelfand AA. Infant Colic. Semin Pediatr Neurol [Internet]. 2016;23(1):79–82.

Lucassen PLBJ, Assendelft WJJ, Van Eijk JTM, Gubbels JW, Douwes AC, Van Geldrop WJ. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child. 2001;84(5):398–403.

Grossi E, Migliore L, Muratori F. Pregnancy risk factors related to autism: An Italian case-control study in mothers of children with autism spectrum disorders (ASD), their siblings and of typically developing children. J Dev Orig Health Dis. 2018;9(4):442–9.

Angelidou A, Asadi S, Alysandratos KD, Karagkouni A, Kourembanas S, Theoharides TC. Perinatal stress, brain inflammation and risk of autism-Review and proposal. BMC Pediatr. 2012;12:1–12.

Varcin KJ, Alvares GA, Uljarević M, Whitehouse AJO. Prenatal maternal stress events and phenotypic outcomes in Autism Spectrum Disorder. Autism Res. 2017;10(11):1866–77.




DOI: https://doi.org/10.34119/bjhrv4n1-096

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