Fibroadenoma versus Tumor Phyllodes: como diferenciá-los? / Fibroadenoma versus Tumor Phylodes: how to differentiate them?

Ismael Gomes da Rocha, Vanessa Lino dos Santos Silva, Eduardo Isidoro Carneiro Beltrão, Carlos Daniel Passos Lobo, Jacinto Costa da Silva Neto

Abstract


Objetivo: avaliar evidências científicas que explicam sobre os critérios diagnósticos que podem ser utilizados para diferenciação entre filodes tumorais e Fibroadenoma. Métodos: A revisão consistiu da busca de artigos disponíveis nas principais bases de dados e foram adotadas como as seguintes palavras-chaves: “Fibroadenoma” e “Tumor Phyllodes”. Foram utilizados os seguintes critérios para a seleção: estudos realizados no período de 2008 a 2018, que explicassem sobre as características para um diagnóstico de diferenciação desses tumores. Foram selecionados 15 artigos que contemplaram os critérios. Results: Observou-se que vários estudos utilizaram a deposição de colágeno como um possível marcador de diferenciação, bem como expressão de marcadores moleculares que auxiliam na distinção e servem para observação da progressão da neoplasia. Os exames de imagens podem ser utilizados, mas variáveis. Enquanto em nível citopatológico e histológico há muita problemática diagnóstica porque os dois tumores têm características semelhantes. Conclusão: As evidências analisadas para uma melhor diferenciação de Tumor Phyllodes e Fibroadenoma, apresentam promissoras, principalmente a nível molecular. Por outro lado, uma dificuldade de diferenciação cito e histopatológica, muitas vezes nos exames de imagens, ainda continua presente nos diagnósticos.


Keywords


Diagnóstico, Fibroadenoma, Tumor Phyllodes

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DOI: https://doi.org/10.34119/bjhrv4n1-069

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